103 items (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	map3k2	Mitogen-activated protein kinase kinase kinase 2. (650 aa)
	LOC101160576	Uncharacterized protein. (454 aa)
	H2L6E1_ORYLA	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (364 aa)
	calml4	Calmodulin-like 4a. (153 aa)
	map3k3	Mitogen-activated protein kinase kinase kinase 3. (617 aa)
	lhb	Luteinizing hormone, beta polypeptide. (146 aa)
	LOC101169984	Receptor protein-tyrosine kinase. (1191 aa)
	GNAS	Uncharacterized protein. (379 aa)
	LOC101167719	Uncharacterized protein. (357 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
	LOC101157952	Mitogen-activated protein kinase. (420 aa)
	LOC100049529	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
	LOC101168718	Uncharacterized protein. (358 aa)
	LOC101166373	GNAS complex locus. (379 aa)
	gnrh3	GnRH-associated peptide 3; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (90 aa)
	LOC101166779	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (949 aa)
	LOC101164658	Uncharacterized protein. (242 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	calm3	Calmodulin-A; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC101171699	Matrix metallopeptidase 14a (membrane-inserted). (570 aa)
	LOC101163933	Mitogen-activated protein kinase kinase 6. (358 aa)
	LOC101155216	Phospholipase. (950 aa)
	gnrh-r3	Gonadotropin-releasing hormone receptor 3. (394 aa)
	gnrh2	GnRH-associated peptide 2; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (80 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC101159746	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	LOC101175696	Mitogen-activated protein kinase. (354 aa)
	ptk2b	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (995 aa)
	LOC101154993	Mitogen-activated protein kinase. (368 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)
	pla2g4a	Phospholipase A2. (745 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1242 aa)
	jun	BZIP domain-containing protein; Belongs to the bZIP family. (306 aa)
	Itpr2	Inositol 1,4,5-trisphosphate receptor, type 2. (1587 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	raf1	Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	CDC42	Cell division cycle 42. (191 aa)
	GNRHR	Gonadotropin releasing hormone receptor. (435 aa)
	LOC101165720	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1110 aa)
	LOC101162414	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1011 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
	LOC101161353	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class). (359 aa)
	LOC101159207	Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (851 aa)
	H2MHV7_ORYLA	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (649 aa)
	LOC101167700	Inositol 1,4,5-trisphosphate receptor, type 1a. (2664 aa)
	LOC101160964	Uncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
	LOC101163149	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1453 aa)
	grb2	Growth factor receptor-bound protein 2b. (218 aa)
	LOC101159668	Mitogen-activated protein kinase. (361 aa)
	LOC101165887	ETS transcription factor ELK1. (571 aa)
	egfr	Receptor protein-tyrosine kinase. (1185 aa)
	LOC101160956	JunE proto-oncogene, AP-1 transcription factor subunit. (425 aa)
	pla2g4c	Uncharacterized protein. (377 aa)
	gnrh-r1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (398 aa)
	adcy7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
	LOC101156096	Heparin-binding EGF-like growth factor a. (233 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	LOC101164997	Mitogen-activated protein kinase. (384 aa)
	LOC101166500	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	LOC101160731	Mitogen-activated protein kinase. (360 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	LOC101174454	Uncharacterized protein. (191 aa)
	LOC101157651	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1127 aa)
	LOC101161464	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	LOC101168799	Mitogen-activated protein kinase. (488 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
	map2k4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (428 aa)
	LOC101154954	Zgc:55558. (189 aa)
	LOC101169035	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
	LOC101172229	Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1; Belongs to the protein kinase superfamily. (492 aa)
	cga	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	prkcd	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1231 aa)
	mmp14	ZnMc domain-containing protein. (610 aa)
	Cacna1d	Calcium channel, voltage-dependent, L type, alpha 1D subunit, b. (99 aa)
	ENSORLP00000032968	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (287 aa)
	LOC101175365	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
	LOC101163742	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	LOC101164400	Uncharacterized protein. (191 aa)
	LOC101173517	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2301 aa)
	LOC101162042	Mitogen-activated protein kinase. (361 aa)
	LOC101164480	Tyrosine-protein kinase. (551 aa)
	atf4-2	BZIP domain-containing protein. (436 aa)
	pld1	Phospholipase. (1041 aa)
	map3k4	Mitogen-activated protein kinase kinase kinase 4. (1590 aa)
	LOC101161098	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (463 aa)
	plcb2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1248 aa)
	LOC101170843	Protein kinase domain-containing protein. (336 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
	LOC101159287	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2. (551 aa)
	gnrh-r2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (373 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	mmp2	Uncharacterized protein. (657 aa)
	ENSORLP00000040805	EF-hand domain-containing protein. (275 aa)
	LOC101175514	Phospholipase. (1031 aa)
	LOC101156127	Mitogen-activated protein kinase kinase kinase 22. (621 aa)
	LOC101172459	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
	LOC101170876	Uncharacterized protein; Belongs to the protein kinase superfamily. (354 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	GNAS	ENSORLP00000026353	ENSORLP00000004563	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.861
ADCY3	H2L6E1_ORYLA	ENSORLP00000026353	ENSORLP00000001388	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.448
ADCY3	LOC101159207	ENSORLP00000026353	ENSORLP00000018049	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.415
ADCY3	LOC101160964	ENSORLP00000026353	ENSORLP00000018527	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
ADCY3	LOC101162414	ENSORLP00000026353	ENSORLP00000017068	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.450
ADCY3	LOC101163149	ENSORLP00000026353	ENSORLP00000018900	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.624
ADCY3	LOC101163742	ENSORLP00000026353	ENSORLP00000033579	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.726
ADCY3	LOC101166373	ENSORLP00000026353	ENSORLP00000007194	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.861
ADCY3	LOC101169035	ENSORLP00000026353	ENSORLP00000030459	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.442
ADCY3	LOC101170876	ENSORLP00000026353	ENSORLP00000045423	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
ADCY3	adcy5	ENSORLP00000026353	ENSORLP00000038908	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.437
ADCY3	adcy6	ENSORLP00000026353	ENSORLP00000027535	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.441
ADCY3	adcy7	ENSORLP00000026353	ENSORLP00000026023	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.425
ADCY3	adcy8	ENSORLP00000026353	ENSORLP00000032517	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.432
ADCY3	calm3	ENSORLP00000026353	ENSORLP00000008598	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-A; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.918
ADCY3	calml4	ENSORLP00000026353	ENSORLP00000002150	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like 4a.	0.914
ADCY3	map3k2	ENSORLP00000026353	ENSORLP00000000797	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Mitogen-activated protein kinase kinase kinase 2.	0.625
ADCY3	prkacb	ENSORLP00000026353	ENSORLP00000026566	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
CDC42	LOC101154993	ENSORLP00000015084	ENSORLP00000011305	Cell division cycle 42.	Mitogen-activated protein kinase.	0.795
CDC42	LOC101155216	ENSORLP00000015084	ENSORLP00000010066	Cell division cycle 42.	Phospholipase.	0.426