96 items (Oryzias latipes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa)
	cpeb3	Cytoplasmic polyadenylation element binding protein 3. (619 aa)
	LOC105358374	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (802 aa)
	H2L6E1_ORYLA	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (364 aa)
	LOC101174244	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC101165012	Ribosomal protein S6 kinase. (734 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
	anapc10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (413 aa)
	LOC101157952	Mitogen-activated protein kinase. (420 aa)
	LOC101174851	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	pkmyt1	Protein kinase, membrane associated tyrosine/threonine 1. (568 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	hdx	Ribosomal protein S6 kinase. (783 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101168152	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC101175696	Mitogen-activated protein kinase. (354 aa)
	LOC101154993	Mitogen-activated protein kinase. (368 aa)
	LOC101174862	Fizzy/cell division cycle 20 related 1b. (492 aa)
	LOC101155144	Uncharacterized protein. (466 aa)
	gnai3	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	raf1	Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
	LOC101169506	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (730 aa)
	LOC101159747	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	LOC101165720	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1110 aa)
	LOC101162414	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1011 aa)
	ccnb1	G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. (404 aa)
	LOC101162061	Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (411 aa)
	LOC101155451	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC101159207	Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (851 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	LOC101160964	Uncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
	LOC101163149	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1453 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (498 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	LOC101157265	Uncharacterized protein. (354 aa)
	cpeb2	Cytoplasmic polyadenylation element binding protein 2. (755 aa)
	LOC101159668	Mitogen-activated protein kinase. (361 aa)
	araf	A-Raf proto-oncogene, serine/threonine kinase. (607 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	H2MSU3_ORYLA	Uncharacterized protein. (420 aa)
	cdc25b	Rhodanese domain-containing protein. (572 aa)
	cdk1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C- terminus of RNA polymerase II. Catalytic component of MPF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (429 aa)
	mad2l1	HORMA domain-containing protein. (206 aa)
	adcy7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
	LOC101163728	Uncharacterized protein. (409 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	LOC101164997	Mitogen-activated protein kinase. (384 aa)
	LOC101166500	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
	igf1	Insulin-like growth factor 1. (199 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (559 aa)
	LOC101160731	Mitogen-activated protein kinase. (360 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	ccnb3	Cyclin B3; Belongs to the cyclin family. (425 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC101169648	Ribosomal protein S6 kinase. (748 aa)
	kif22	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (619 aa)
	cpeb1	Cytoplasmic polyadenylation element binding protein 1b. (584 aa)
	LOC101163560	Tyrosine-protein kinase receptor. (1405 aa)
	LOC101168799	Mitogen-activated protein kinase. (488 aa)
	LOC101154954	Zgc:55558. (189 aa)
	LOC101173298	Tyrosine-protein kinase receptor. (1408 aa)
	LOC101169035	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
	kras	GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	gnai2	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1231 aa)
	pde3b	Phosphodiesterase. (1103 aa)
	hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (724 aa)
	bub1	BUB1 mitotic checkpoint serine/threonine kinase. (1115 aa)
	LOC101163742	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	spdya	Speedy protein A. (310 aa)
	pik3r3	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (719 aa)
	LOC100125446	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (226 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (750 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (823 aa)
	LOC101162468	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC101162042	Mitogen-activated protein kinase. (361 aa)
	LOC101167671	Serine/threonine kinase 10. (1022 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
	LOC101162905	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	PLK1	Serine/threonine-protein kinase PLK. (582 aa)
	LOC101160327	Cytoplasmic polyadenylation element binding protein 4a. (741 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (722 aa)
	mos	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (326 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
	LOC101172459	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
	LOC101172253	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	Cdc27	Cell division cycle 27. (382 aa)
	LOC101163402	Ribosomal protein S6 kinase. (746 aa)
	LOC101170876	Uncharacterized protein; Belongs to the protein kinase superfamily. (354 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	CPEB4	ENSORLP00000026353	ENSORLP00000034309	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 4.	0.580
ADCY3	H2L6E1_ORYLA	ENSORLP00000026353	ENSORLP00000001388	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.448
ADCY3	LOC101157265	ENSORLP00000026353	ENSORLP00000020086	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.790
ADCY3	LOC101159207	ENSORLP00000026353	ENSORLP00000018049	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.415
ADCY3	LOC101160964	ENSORLP00000026353	ENSORLP00000018527	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
ADCY3	LOC101162414	ENSORLP00000026353	ENSORLP00000017068	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.450
ADCY3	LOC101163149	ENSORLP00000026353	ENSORLP00000018900	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.624
ADCY3	LOC101163742	ENSORLP00000026353	ENSORLP00000033579	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.726
ADCY3	LOC101169035	ENSORLP00000026353	ENSORLP00000030459	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.442
ADCY3	LOC101170876	ENSORLP00000026353	ENSORLP00000045423	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.726
ADCY3	LOC105358374	ENSORLP00000026353	ENSORLP00000001335	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.790
ADCY3	adcy5	ENSORLP00000026353	ENSORLP00000038908	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.437
ADCY3	adcy6	ENSORLP00000026353	ENSORLP00000027535	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.441
ADCY3	adcy7	ENSORLP00000026353	ENSORLP00000026023	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.425
ADCY3	adcy8	ENSORLP00000026353	ENSORLP00000032517	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.432
ADCY3	cpeb1	ENSORLP00000026353	ENSORLP00000029310	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 1b.	0.501
ADCY3	cpeb2	ENSORLP00000026353	ENSORLP00000020310	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 2.	0.580
ADCY3	cpeb3	ENSORLP00000026353	ENSORLP00000000893	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cytoplasmic polyadenylation element binding protein 3.	0.597
ADCY3	gnai2	ENSORLP00000026353	ENSORLP00000032440	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).	0.790
ADCY3	gnai3	ENSORLP00000026353	ENSORLP00000013487	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.790