STRINGSTRING
LOC105358374 LOC105358374 H2L6E1_ORYLA H2L6E1_ORYLA calml4 calml4 H2L9W7_ORYLA H2L9W7_ORYLA LOC101158674 LOC101158674 LOC101160197 LOC101160197 LOC101171502 LOC101171502 GNAS GNAS LOC101164317 LOC101164317 Fzd2 Fzd2 tyrp1 tyrp1 LOC101164953 LOC101164953 LOC101173867 LOC101173867 TYR TYR LOC101171479 LOC101171479 LOC101167719 LOC101167719 Fzd8 Fzd8 map2k2 map2k2 LOC100049529 LOC100049529 LOC101168718 LOC101168718 LOC101166373 LOC101166373 LOC101164972 LOC101164972 calm3 calm3 lef1 lef1 map2k1 map2k1 wnt2bb wnt2bb adcy9 adcy9 LOC101160069 LOC101160069 PRKCB PRKCB LOC101159746 LOC101159746 gnao1 gnao1 edn1 edn1 Mc1r Mc1r PLCB4 PLCB4 PLCB1 PLCB1 ednr ednr H2M3J6_ORYLA H2M3J6_ORYLA gnai3 gnai3 fzd4 fzd4 LOC101158386 LOC101158386 LOC101155025 LOC101155025 LOC101170723 LOC101170723 Wnt7a Wnt7a hras hras raf1 raf1 fzd9 fzd9 tcf7l1 tcf7l1 LOC101159747 LOC101159747 wnt3 wnt3 wnt4 wnt4 wnt4b wnt4b wnt11 wnt11 LOC101165720 LOC101165720 LOC105357082 LOC105357082 LOC101162414 LOC101162414 fzd10 fzd10 PRKCA PRKCA dvl3 dvl3 LOC101159207 LOC101159207 LOC101160964 LOC101160964 LOC101163149 LOC101163149 H2MKU6_ORYLA H2MKU6_ORYLA fzd3 fzd3 LOC101157265 LOC101157265 wnt9a wnt9a dct dct LOC100049225 LOC100049225 wnt6 wnt6 wnt16 wnt16 LOC101162030 LOC101162030 adcy7 adcy7 wnt10b wnt10b ADCY3 ADCY3 LOC101166500 LOC101166500 LOC101163392 LOC101163392 prkacb prkacb dvl2 dvl2 LOC101171501 LOC101171501 adcy6 adcy6 Kitlg Kitlg kit kit LOC101161464 LOC101161464 creb3l1 creb3l1 LOC101154954 LOC101154954 LOC101154972 LOC101154972 LOC101169035 LOC101169035 LOC101164105 LOC101164105 LOC111948314 LOC111948314 LOC101172229 LOC101172229 LOC105356229 LOC105356229 ctnnb1 ctnnb1 kras kras gnai2 gnai2 adcy8 adcy8 LOC101168870 LOC101168870 pomc pomc wnt5b wnt5b LOC101175365 LOC101175365 MITF MITF LOC101161292 LOC101161292 fzd6 fzd6 LOC101163742 LOC101163742 LOC101167706 LOC101167706 LOC101156794 LOC101156794 wnt3a wnt3a creb3l2 creb3l2 LOC101163732 LOC101163732 wnt1 wnt1 tcf7 tcf7 plcb2 plcb2 LOC101164921 LOC101164921 adcy5 adcy5 LOC101159287 LOC101159287 LOC101162905 LOC101162905 FZD3 FZD3 ENSORLP00000041514 ENSORLP00000041514 tyr tyr LOC101164777 LOC101164777 dvl1 dvl1 LOC101172459 LOC101172459 WNT7A WNT7A LOC101170876 LOC101170876
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105358374Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
H2L6E1_ORYLAGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (364 aa)
calml4Calmodulin-like 4a. (153 aa)
H2L9W7_ORYLAUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LOC101158674cAMP responsive element binding protein 1. (315 aa)
LOC101160197E1A binding protein p300 a. (2781 aa)
LOC101171502Uncharacterized protein. (768 aa)
GNASUncharacterized protein. (379 aa)
LOC101164317BZIP domain-containing protein. (487 aa)
Fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
tyrp1Tyrosinase related protein 1. (521 aa)
LOC101164953Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (954 aa)
LOC101173867Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TYRTyrosinase. (544 aa)
LOC101171479cAMP responsive element binding protein 3-like 3a. (434 aa)
LOC101167719Uncharacterized protein. (357 aa)
Fzd8Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (573 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa)
LOC1000495291-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1237 aa)
LOC101168718Uncharacterized protein. (358 aa)
LOC101166373GNAS complex locus. (379 aa)
LOC101164972Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
calm3Calmodulin-A; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
lef1Lymphoid enhancer-binding factor 1. (379 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
adcy9CREB binding protein b. (2423 aa)
LOC101160069Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (448 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
LOC101159746Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
gnao1Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b. (354 aa)
edn1Endothelin 1. (220 aa)
Mc1rMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (334 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1242 aa)
ednrG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (413 aa)
H2M3J6_ORYLAUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
gnai3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
LOC101158386Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (419 aa)
LOC101155025Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LOC101170723Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
Wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
raf1Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
fzd9Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
tcf7l1HMG box domain-containing protein. (574 aa)
LOC101159747Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
wnt4bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC101165720Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1110 aa)
LOC105357082Uncharacterized protein. (245 aa)
LOC101162414Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1011 aa)
fzd10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (709 aa)
dvl3Dishevelled segment polarity protein 3a. (685 aa)
LOC101159207Adenylate cyclase 2b (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (851 aa)
LOC101160964Uncharacterized protein; Belongs to the protein kinase superfamily. (359 aa)
LOC101163149Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1453 aa)
H2MKU6_ORYLAUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
fzd3Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (695 aa)
LOC101157265Uncharacterized protein. (354 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
dctDopachrome tautomerase. (511 aa)
LOC100049225Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (427 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LOC101162030Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (429 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
LOC101166500Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
LOC101163392CREB binding protein a. (2409 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
dvl2Dishevelled segment polarity protein 2. (770 aa)
LOC101171501Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
adcy6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
KitlgKit ligand a. (233 aa)
kitUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (994 aa)
LOC101161464Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
creb3l1cAMP responsive element binding protein 3-like 1. (505 aa)
LOC101154954Zgc:55558. (189 aa)
LOC101154972Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
LOC101169035Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
LOC101164105cAMP responsive element binding protein 1b. (329 aa)
LOC111948314HMG box domain-containing protein. (548 aa)
LOC101172229Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1; Belongs to the protein kinase superfamily. (492 aa)
LOC105356229BZIP domain-containing protein. (330 aa)
ctnnb1Catenin (cadherin-associated protein), beta 1. (783 aa)
krasGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. (189 aa)
gnai2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). (355 aa)
adcy8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1231 aa)
LOC101168870E1A binding protein p300 b. (2760 aa)
pomcProopiomelanocortin. (212 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (436 aa)
LOC1011753651-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
MITFMelanocyte inducing transcription factor b. (511 aa)
LOC101161292Tyrosinase-related protein 1b. (540 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (682 aa)
LOC101163742Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
LOC101167706Uncharacterized protein. (354 aa)
LOC101156794Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
creb3l2cAMP responsive element binding protein 3-like 2. (544 aa)
LOC101163732Microphthalmia-associated transcription factor 2 isoform m. (406 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
tcf7Transcription factor 7. (536 aa)
plcb21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1248 aa)
LOC101164921Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1196 aa)
LOC101159287Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2. (551 aa)
LOC101162905Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
FZD3Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (755 aa)
ENSORLP00000041514Frizzled class receptor 1. (245 aa)
tyrTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. (547 aa)
LOC101164777Uncharacterized protein. (265 aa)
dvl1Dishevelled segment polarity protein 1a. (728 aa)
LOC101172459Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1203 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LOC101170876Uncharacterized protein; Belongs to the protein kinase superfamily. (354 aa)
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (22%) [HD]