(67 nodes) Ubiquitin conjugating enzyme activity, and Ubiquitin activating enzyme activity network (Acanthochromis polyacanthus)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ube2w	UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
	LOC110946601	Ubiquitin-conjugating enzyme E2 variant 1. (163 aa)
	otub1	Ubiquitin thioesterase. (280 aa)
	LOC110954070	Ubiquitin-conjugating enzyme E2D 1a; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	ENSAPOP00000003675	Ubiquitin-like domain-containing protein. (84 aa)
	ube2g1	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	rlim	Ring finger protein, LIM domain interacting. (700 aa)
	ENSAPOP00000005350	UBA_e1_C domain-containing protein. (61 aa)
	arih1	RBR-type E3 ubiquitin transferase. (529 aa)
	LOC110954209	Uncharacterized protein. (155 aa)
	ube2h	Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	ENSAPOP00000007183	UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa)
	birc6	Baculoviral IAP repeat containing 6. (3924 aa)
	LOC110972087	Ubiquitin-like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1076 aa)
	LOC110961572	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
	ube2a	Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	LOC110955007	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	LOC110972776	E3 ubiquitin protein ligase. (1028 aa)
	LOC110972774	E3 ubiquitin-protein ligase BRE1A-like. (1028 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (239 aa)
	LOC110947992	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (481 aa)
	LOC110949710	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (191 aa)
	traf7	TNF receptor-associated factor 7. (712 aa)
	c1qtnf12	C1q and TNF related 12. (320 aa)
	LOC110966765	Ubiquitin-like domain-containing protein. (77 aa)
	UBE2H	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	LOC110960810	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	LOC110967314	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (316 aa)
	LOC110971799	Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	ube2n	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	ubox5	U-box domain containing 5. (652 aa)
	LOC110967295	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	rnf4	RING-type domain-containing protein. (203 aa)
	LOC110949071	Ubiquitin-conjugating enzyme E2B (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	LOC110955456	Ubiquitin-like 7b (bone marrow stromal cell-derived). (379 aa)
	LOC110960708	Ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
	LOC110951306	Cell division cycle 34 homolog (S. cerevisiae) a; Belongs to the ubiquitin-conjugating enzyme family. (241 aa)
	LOC110968979	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	ube2z	Ubiquitin-conjugating enzyme E2Z. (404 aa)
	ENSAPOP00000021574	Ubiquitin-like domain-containing protein. (131 aa)
	LOC110956463	Ubiquitin protein ligase E3A. (825 aa)
	LOC110952339	Ubiquitin conjugating enzyme E2 A, like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	ube2r2	Ubiquitin-conjugating enzyme E2R 2; Belongs to the ubiquitin-conjugating enzyme family. (270 aa)
	rnf217	RBR-type E3 ubiquitin transferase. (566 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	LOC110967322	Ubiquitin-conjugating enzyme E2D 3; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	ube2k	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	LOC110956313	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
	uba6	Ubiquitin like modifier activating enzyme 6. (1017 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (292 aa)
	LOC110972085	Uncharacterized protein; Belongs to the ubiquitin-activating E1 family. (1076 aa)
	LOC110947201	Ubiquitin-like. (74 aa)
	ENSAPOP00000029317	Uncharacterized protein. (165 aa)
	LOC110949720	Ubiquitin-conjugating enzyme E2E 1. (235 aa)
	ube2j2	Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast). (261 aa)
	ube2j1	Ubiquitin-conjugating enzyme E2, J1. (315 aa)
	LOC110963171	Ubiquitin-conjugating enzyme E2D 1b; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	uba1	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1057 aa)
	ENSAPOP00000031975	Uncharacterized protein. (92 aa)
	ENSAPOP00000031989	UBIQUITIN_CONJUGAT_2 domain-containing protein. (66 aa)
	rnf40	E3 ubiquitin protein ligase. (1003 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (893 aa)
	LOC110957105	Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (143 aa)
	LOC110953629	Ubiquitin-conjugating enzyme E2D 4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	LOC110948967	Cell division cycle 34 homolog (S. cerevisiae) b; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
	rnf181	Ring finger protein 181. (157 aa)

Your Current Organism:

Acanthochromis polyacanthus

NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPOP00000003675	ENSAPOP00000005350	ENSAPOP00000003675	ENSAPOP00000005350	Ubiquitin-like domain-containing protein.	UBA_e1_C domain-containing protein.	0.969
ENSAPOP00000003675	ENSAPOP00000007183	ENSAPOP00000003675	ENSAPOP00000007183	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.906
ENSAPOP00000003675	ENSAPOP00000021574	ENSAPOP00000003675	ENSAPOP00000021574	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.997
ENSAPOP00000003675	ENSAPOP00000029317	ENSAPOP00000003675	ENSAPOP00000029317	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.969
ENSAPOP00000003675	ENSAPOP00000031975	ENSAPOP00000003675	ENSAPOP00000031975	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.767
ENSAPOP00000003675	ENSAPOP00000031989	ENSAPOP00000003675	ENSAPOP00000031989	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.767
ENSAPOP00000003675	LOC110946601	ENSAPOP00000003675	ENSAPOP00000002326	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 1.	0.987
ENSAPOP00000003675	LOC110947201	ENSAPOP00000003675	ENSAPOP00000026534	Ubiquitin-like domain-containing protein.	Ubiquitin-like.	0.990
ENSAPOP00000003675	LOC110947992	ENSAPOP00000003675	ENSAPOP00000012296	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.984
ENSAPOP00000003675	LOC110948967	ENSAPOP00000003675	ENSAPOP00000034572	Ubiquitin-like domain-containing protein.	Cell division cycle 34 homolog (S. cerevisiae) b; Belongs to the ubiquitin-conjugating enzyme family.	0.966
ENSAPOP00000003675	LOC110949071	ENSAPOP00000003675	ENSAPOP00000016446	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2B (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.	0.967
ENSAPOP00000003675	LOC110949710	ENSAPOP00000003675	ENSAPOP00000012805	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.767
ENSAPOP00000003675	LOC110949720	ENSAPOP00000003675	ENSAPOP00000029558	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2E 1.	0.767
ENSAPOP00000003675	LOC110951306	ENSAPOP00000003675	ENSAPOP00000019506	Ubiquitin-like domain-containing protein.	Cell division cycle 34 homolog (S. cerevisiae) a; Belongs to the ubiquitin-conjugating enzyme family.	0.966
ENSAPOP00000003675	LOC110952339	ENSAPOP00000003675	ENSAPOP00000021679	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 A, like; Belongs to the ubiquitin-conjugating enzyme family.	0.967
ENSAPOP00000003675	LOC110953629	ENSAPOP00000003675	ENSAPOP00000033969	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2D 4 (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.952
ENSAPOP00000003675	LOC110954070	ENSAPOP00000003675	ENSAPOP00000003229	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2D 1a; Belongs to the ubiquitin-conjugating enzyme family.	0.952
ENSAPOP00000003675	LOC110954209	ENSAPOP00000003675	ENSAPOP00000005899	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.525
ENSAPOP00000003675	LOC110955007	ENSAPOP00000003675	ENSAPOP00000011319	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.966
ENSAPOP00000003675	LOC110955456	ENSAPOP00000003675	ENSAPOP00000017785	Ubiquitin-like domain-containing protein.	Ubiquitin-like 7b (bone marrow stromal cell-derived).	0.914