(97 nodes) Regulation of mRNA splicing, via spliceosome network (Acanthochromis polyacanthus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC110963232	RNA binding motif protein 25b. (806 aa)
	celf1	Cugbp, Elav-like family member 1. (489 aa)
	dazap1	DAZ associated protein 1. (435 aa)
	LOC110953124	RRM domain-containing protein. (463 aa)
	LOC110956666	RNA binding motif protein 24a. (231 aa)
	LOC110966115	Uncharacterized protein. (501 aa)
	LOC110961957	RNA binding motif protein 6. (1322 aa)
	KHDRBS3	KH RNA binding domain containing, signal transduction associated 3. (230 aa)
	SRSF3	Serine and arginine rich splicing factor 3b. (165 aa)
	prpf19	Pre-mRNA processing factor 19. (505 aa)
	LOC110969183	RNA binding motif protein 25a. (824 aa)
	tra2a	Transformer 2 alpha homolog. (293 aa)
	LOC110958652	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (670 aa)
	eif4a3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (406 aa)
	rbm5	RNA binding motif protein 5. (853 aa)
	ENSAPOP00000029566	RRM domain-containing protein. (356 aa)
	LOC110953262	SAP domain-containing protein. (1742 aa)
	LOC110964873	Uncharacterized protein. (619 aa)
	snrpc	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (148 aa)
	ythdc1	YTH domain containing 1. (622 aa)
	LOC110951533	Serine and arginine rich splicing factor 9. (244 aa)
	sf1	Splicing factor 1. (678 aa)
	ENSAPOP00000027446	Uncharacterized protein. (110 aa)
	LOC110952142	KH domain containing, RNA binding, signal transduction associated 1a. (400 aa)
	LOC110960997	Serine/arginine repetitive matrix 4. (621 aa)
	ENSAPOP00000026819	Uncharacterized protein. (114 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (286 aa)
	LOC110948067	RRM domain-containing protein. (244 aa)
	LOC110964626	Uncharacterized protein. (531 aa)
	jmjd6	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (403 aa)
	ENSAPOP00000025392	Uncharacterized protein. (351 aa)
	SMU1	SMU1 DNA replication regulator and spliceosomal factor. (513 aa)
	sap18	Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins. (151 aa)
	celf3	Cugbp, Elav-like family member 3a. (582 aa)
	sfswap	Splicing factor SWAP. (1012 aa)
	LOC110965336	RNA binding fox-1 homolog 2. (473 aa)
	LOC110949430	Cugbp, Elav-like family member 5a. (530 aa)
	wtap	WT1 associated protein. (429 aa)
	LOC110970185	Fragile X mental retardation, autosomal homolog 2. (673 aa)
	celf4	CUGBP, Elav-like family member 4. (525 aa)
	fam172a	Family with sequence similarity 172 member A. (422 aa)
	LOC110958171	Neuro-oncological ventral antigen 1. (502 aa)
	LOC110970868	KH domain containing, RNA binding, signal transduction associated 1b. (356 aa)
	ncl	Nucleolin. (713 aa)
	LOC110955934	RRM domain-containing protein. (288 aa)
	srsf7	Serine and arginine rich splicing factor 7a. (253 aa)
	snw1	SNW domain containing 1. (536 aa)
	u2af2	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (323 aa)
	ENSAPOP00000018752	RRM domain-containing protein. (129 aa)
	LOC110948477	RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (381 aa)
	LOC110957779	Uncharacterized protein. (939 aa)
	LOC110966738	Apoptotic chromatin condensation inducer 1b. (1299 aa)
	LOC110959591	Si:dkey-205h23.2. (491 aa)
	nsrp1	Nuclear speckle splicing regulatory protein 1. (478 aa)
	rbm15	RNA binding motif protein 15. (850 aa)
	ybx1	Y box binding protein 1. (305 aa)
	LOC110949651	RNA binding motif protein 10. (946 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (635 aa)
	LOC110947916	RRM domain-containing protein. (175 aa)
	sf3b4	Splicing factor 3b, subunit 4. (400 aa)
	LOC110957235	Uncharacterized protein. (814 aa)
	CELF2	Cugbp, Elav-like family member 2. (520 aa)
	raver1	Ribonucleoprotein, PTB-binding 1. (796 aa)
	fxr1	Fragile X mental retardation, autosomal homolog 1. (691 aa)
	LOC110954930	RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (378 aa)
	magoh	Mago homolog, exon junction complex subunit. (147 aa)
	LOC110959705	Cugbp, Elav-like family member 3b. (398 aa)
	LOC110952820	QKI, KH domain containing, RNA binding a. (334 aa)
	larp7	La ribonucleoprotein domain family, member 7. (566 aa)
	rbm15b	RNA binding motif protein 15B. (412 aa)
	ENSAPOP00000011710	Uncharacterized protein. (119 aa)
	zc3h10	Zinc finger CCCH-type containing 10. (548 aa)
	LOC110948689	RNA binding motif protein 7. (255 aa)
	RBM20	RNA binding motif protein 20. (942 aa)
	ENSAPOP00000008697	RNA binding motif protein 39b. (267 aa)
	rbm8a	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (175 aa)
	ENSAPOP00000007409	Peptidase S59 domain-containing protein. (160 aa)
	khdrbs2	KH domain containing, RNA binding, signal transduction associated 2. (343 aa)
	LOC110964615	SMU1 DNA replication regulator and spliceosomal factor b. (512 aa)
	ENSAPOP00000006589	Nup96 domain-containing protein. (399 aa)
	rbmx	RNA binding motif protein X-linked. (390 aa)
	fmr1	Fragile X mental retardation 1. (604 aa)
	LOC110951202	Uncharacterized protein. (520 aa)
	LOC110949902	Uncharacterized protein. (834 aa)
	LOC110966454	RNA binding motif protein 24b. (236 aa)
	cirbp	Cold inducible RNA binding protein b. (214 aa)
	LOC110955897	RE1-silencing transcription factor. (913 aa)
	LOC110964759	Transformer 2 beta homolog. (279 aa)
	LOC110948293	RRM domain-containing protein. (249 aa)
	rbfox1	RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events. (411 aa)
	LOC110961191	Uncharacterized protein; Belongs to the DEAD box helicase family. (649 aa)
	LOC110958152	Ribonucleoprotein, PTB-binding 2. (834 aa)
	LOC110948931	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (620 aa)
	LOC110959425	QKI, KH domain containing, RNA binding 2. (341 aa)
	LOC110954129	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (466 aa)
	PUF60	Poly-U binding splicing factor b. (526 aa)
	srrm1	Serine/arginine repetitive matrix 1. (864 aa)

Your Current Organism:

Acanthochromis polyacanthus

NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX5	ENSAPOP00000006589	ENSAPOP00000015247	ENSAPOP00000006589	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Nup96 domain-containing protein.	0.479
DDX5	ENSAPOP00000007409	ENSAPOP00000015247	ENSAPOP00000007409	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Peptidase S59 domain-containing protein.	0.479
DDX5	ENSAPOP00000008697	ENSAPOP00000015247	ENSAPOP00000008697	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RNA binding motif protein 39b.	0.758
DDX5	ENSAPOP00000011710	ENSAPOP00000015247	ENSAPOP00000011710	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.648
DDX5	ENSAPOP00000025392	ENSAPOP00000015247	ENSAPOP00000025392	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.479
DDX5	ENSAPOP00000026819	ENSAPOP00000015247	ENSAPOP00000026819	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.758
DDX5	ENSAPOP00000029566	ENSAPOP00000015247	ENSAPOP00000029566	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.521
DDX5	LOC110947916	ENSAPOP00000015247	ENSAPOP00000015208	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.554
DDX5	LOC110948477	ENSAPOP00000015247	ENSAPOP00000018278	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events.	0.521
DDX5	LOC110948689	ENSAPOP00000015247	ENSAPOP00000010346	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RNA binding motif protein 7.	0.698
DDX5	LOC110948931	ENSAPOP00000015247	ENSAPOP00000001437	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family.	0.894
DDX5	LOC110949651	ENSAPOP00000015247	ENSAPOP00000015268	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RNA binding motif protein 10.	0.539
DDX5	LOC110949902	ENSAPOP00000015247	ENSAPOP00000004352	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.539
DDX5	LOC110951533	ENSAPOP00000015247	ENSAPOP00000028463	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Serine and arginine rich splicing factor 9.	0.509
DDX5	LOC110953262	ENSAPOP00000015247	ENSAPOP00000029451	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	SAP domain-containing protein.	0.539
DDX5	LOC110954129	ENSAPOP00000015247	ENSAPOP00000000976	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.570
DDX5	LOC110955934	ENSAPOP00000015247	ENSAPOP00000020201	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.521
DDX5	LOC110957779	ENSAPOP00000015247	ENSAPOP00000016466	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.621
DDX5	LOC110961957	ENSAPOP00000015247	ENSAPOP00000031327	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RNA binding motif protein 6.	0.539
DDX5	LOC110963232	ENSAPOP00000015247	ENSAPOP00000012565	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	RNA binding motif protein 25b.	0.727