(44 nodes) Clathrin-coated vesicle membrane network (Acanthochromis polyacanthus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC110946943	NECAP endocytosis associated 2. (195 aa)
	atp6v0b	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (211 aa)
	LOC110946840	DUF1681 domain-containing protein. (181 aa)
	LOC110953270	AP-1 complex subunit gamma. (805 aa)
	atp6v1d	ATPase H+ transporting V1 subunit D. (248 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	ap3b1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1105 aa)
	ap4m1	AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (441 aa)
	LOC110949101	MFS domain-containing protein. (522 aa)
	dennd1a	DENN/MADD domain containing 1A. (964 aa)
	LOC110947666	Uncharacterized protein. (117 aa)
	LOC110968412	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (937 aa)
	LOC110955950	DUF1681 domain-containing protein. (261 aa)
	AP3B2	AP-3 complex subunit beta. (1127 aa)
	synrg	Synergin, gamma. (1440 aa)
	rassf9	Ras association domain family member 9. (437 aa)
	dab2	DAB adaptor protein 2. (786 aa)
	LOC110961811	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (956 aa)
	LOC110956553	Adaptor related protein complex 1 subunit sigma 3b. (192 aa)
	cgref1	Cell growth regulator with EF-hand domain 1. (266 aa)
	LOC110951350	AP complex subunit beta. (953 aa)
	LOC110955350	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (220 aa)
	LOC110957588	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (434 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
	LOC110962354	Clathrin_bdg domain-containing protein. (663 aa)
	ENSAPOP00000003312	ENTH domain-containing protein. (180 aa)
	epn2	Epsin 2. (602 aa)
	ap1b1	AP complex subunit beta. (957 aa)
	LOC110961069	Epsin 3b. (603 aa)
	LOC110971429	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (153 aa)
	aftph	Aftiphilin a. (738 aa)
	AP1M1	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
	LOC110951068	NECAP endocytosis associated 2. (259 aa)
	LOC110953323	Adaptor related protein complex 1 subunit mu 3; Belongs to the adaptor complexes medium subunit family. (384 aa)
	LOC110970090	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (153 aa)
	LOC110970464	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	LOC110950984	NECAP endocytosis associated 1. (262 aa)
	LOC110946899	Adaptin ear-binding coat-associated protein 2-like. (195 aa)
	LOC110970000	Epsin 1. (655 aa)
	LOC110947562	Aftiphilin-like. (117 aa)
	LOC110947565	Uncharacterized protein. (117 aa)
	ENSAPOP00000023579	Clat_adaptor_s domain-containing protein. (91 aa)
	ap1m2	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (424 aa)
	ap1g1	AP-1 complex subunit gamma. (820 aa)

Your Current Organism:

Acanthochromis polyacanthus

NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1M1	AP1S2	ENSAPOP00000007667	ENSAPOP00000003185	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.873
AP1M1	AP3B2	ENSAPOP00000007667	ENSAPOP00000021228	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-3 complex subunit beta.	0.749
AP1M1	LOC110951350	ENSAPOP00000007667	ENSAPOP00000032773	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit beta.	0.930
AP1M1	LOC110953270	ENSAPOP00000007667	ENSAPOP00000012422	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-1 complex subunit gamma.	0.967
AP1M1	LOC110955350	ENSAPOP00000007667	ENSAPOP00000000434	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.873
AP1M1	LOC110956553	ENSAPOP00000007667	ENSAPOP00000034324	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	Adaptor related protein complex 1 subunit sigma 3b.	0.873
AP1M1	LOC110968412	ENSAPOP00000007667	ENSAPOP00000019033	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.881
AP1M1	LOC110970464	ENSAPOP00000007667	ENSAPOP00000030260	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.873
AP1M1	ap1b1	ENSAPOP00000007667	ENSAPOP00000004838	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit beta.	0.964
AP1M1	ap1g1	ENSAPOP00000007667	ENSAPOP00000010456	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-1 complex subunit gamma.	0.981
AP1M1	ap1m2	ENSAPOP00000007667	ENSAPOP00000023045	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.848
AP1M1	ap2s1	ENSAPOP00000007667	ENSAPOP00000014385	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.634
AP1M1	ap3b1	ENSAPOP00000007667	ENSAPOP00000014756	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.749
AP1M1	epn2	ENSAPOP00000007667	ENSAPOP00000004081	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	Epsin 2.	0.445
AP1S2	AP1M1	ENSAPOP00000003185	ENSAPOP00000007667	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.873
AP1S2	AP3B2	ENSAPOP00000003185	ENSAPOP00000021228	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-3 complex subunit beta.	0.724
AP1S2	ENSAPOP00000023579	ENSAPOP00000003185	ENSAPOP00000023579	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Clat_adaptor_s domain-containing protein.	0.810
AP1S2	LOC110951350	ENSAPOP00000003185	ENSAPOP00000032773	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit beta.	0.914
AP1S2	LOC110953270	ENSAPOP00000003185	ENSAPOP00000012422	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-1 complex subunit gamma.	0.959
AP1S2	LOC110953323	ENSAPOP00000003185	ENSAPOP00000009654	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Adaptor related protein complex 1 subunit mu 3; Belongs to the adaptor complexes medium subunit family.	0.873