(51 nodes) Cytosolic DNA-sensing pathway network (Acanthochromis polyacanthus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (509 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	ENSAPOP00000024267	RHD domain-containing protein. (61 aa)
	LOC110964713	SCY domain-containing protein. (86 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (686 aa)
	polr3k	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	adar	Adenosine deaminase RNA specific. (1321 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	irf7	Interferon regulatory factor 7. (458 aa)
	sting1	Transmembrane protein 173. (413 aa)
	polr3a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (868 aa)
	ENSAPOP00000018551	Uncharacterized protein. (162 aa)
	LOC110971034	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (250 aa)
	LOC110960740	Protein kinase domain-containing protein. (703 aa)
	piwil2	Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (910 aa)
	LOC110969620	Interferon regulatory factor 3. (464 aa)
	polr3b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1132 aa)
	LOC110963172	Zgc:171971. (415 aa)
	LOC110962015	V-rel avian reticuloendotheliosis viral oncogene homolog A. (635 aa)
	tbk1	TANK-binding kinase 1. (723 aa)
	LOC110971296	C-C motif chemokine. (99 aa)
	polr3h	Polymerase (RNA) III (DNA directed) polypeptide H. (217 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	LOC110948093	SCY domain-containing protein. (120 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	polr3g	Polymerase (RNA) III (DNA directed) polypeptide G. (192 aa)
	polr3c	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (545 aa)
	polr3f	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	il1b	Interleukin-1. (246 aa)
	nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (763 aa)
	polr3e	Polymerase (RNA) III (DNA directed) polypeptide E. (687 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	pycard	PYD and CARD domain containing. (189 aa)
	LOC110958655	Component of inhibitor of nuclear factor kappa B kinase complex. (734 aa)
	REL	REL proto-oncogene, NF-kB subunit. (645 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	LOC110967018	Uncharacterized protein. (564 aa)
	LOC110962300	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (309 aa)
	LOC110957018	Uncharacterized protein. (245 aa)
	polr1c	RNA polymerase I and III subunit C. (351 aa)
	ENSAPOP00000034381	CARD domain-containing protein. (100 aa)
	LOC110960072	Caspase b, like; Belongs to the peptidase C14A family. (388 aa)
	LOC110964882	Protein kinase domain-containing protein. (466 aa)
	ENSAPOP00000033383	Uncharacterized protein. (188 aa)
	LOC110964257	RNA polymerase I and III subunit D. (111 aa)
	LOC110967326	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (319 aa)
	ENSAPOP00000030750	RNA_pol_Rpb1_5 domain-containing protein. (168 aa)
	LOC110954996	Uncharacterized protein. (252 aa)
	polr3d	Polymerase (RNA) III (DNA directed) polypeptide D. (386 aa)
	LOC110962713	Uncharacterized protein. (189 aa)

Your Current Organism:

Acanthochromis polyacanthus

NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPOP00000018551	ENSAPOP00000033383	ENSAPOP00000018551	ENSAPOP00000033383	Uncharacterized protein.	Uncharacterized protein.	0.870
ENSAPOP00000018551	LOC110962015	ENSAPOP00000018551	ENSAPOP00000013764	Uncharacterized protein.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.815
ENSAPOP00000018551	LOC110969620	ENSAPOP00000018551	ENSAPOP00000016747	Uncharacterized protein.	Interferon regulatory factor 3.	0.933
ENSAPOP00000018551	REL	ENSAPOP00000018551	ENSAPOP00000003359	Uncharacterized protein.	REL proto-oncogene, NF-kB subunit.	0.815
ENSAPOP00000018551	il1b	ENSAPOP00000018551	ENSAPOP00000006319	Uncharacterized protein.	Interleukin-1.	0.443
ENSAPOP00000018551	irf7	ENSAPOP00000018551	ENSAPOP00000020035	Uncharacterized protein.	Interferon regulatory factor 7.	0.908
ENSAPOP00000024267	LOC110954996	ENSAPOP00000024267	ENSAPOP00000028464	RHD domain-containing protein.	Uncharacterized protein.	0.815
ENSAPOP00000024267	LOC110958655	ENSAPOP00000024267	ENSAPOP00000002293	RHD domain-containing protein.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.931
ENSAPOP00000024267	LOC110960072	ENSAPOP00000024267	ENSAPOP00000034050	RHD domain-containing protein.	Caspase b, like; Belongs to the peptidase C14A family.	0.461
ENSAPOP00000024267	LOC110960740	ENSAPOP00000024267	ENSAPOP00000017086	RHD domain-containing protein.	Protein kinase domain-containing protein.	0.922
ENSAPOP00000024267	LOC110962015	ENSAPOP00000024267	ENSAPOP00000013764	RHD domain-containing protein.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.940
ENSAPOP00000024267	LOC110962300	ENSAPOP00000024267	ENSAPOP00000004816	RHD domain-containing protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.970
ENSAPOP00000024267	LOC110962713	ENSAPOP00000024267	ENSAPOP00000027311	RHD domain-containing protein.	Uncharacterized protein.	0.848
ENSAPOP00000024267	LOC110964882	ENSAPOP00000024267	ENSAPOP00000033797	RHD domain-containing protein.	Protein kinase domain-containing protein.	0.458
ENSAPOP00000024267	LOC110967018	ENSAPOP00000024267	ENSAPOP00000003780	RHD domain-containing protein.	Uncharacterized protein.	0.528
ENSAPOP00000024267	LOC110967326	ENSAPOP00000024267	ENSAPOP00000031121	RHD domain-containing protein.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.458
ENSAPOP00000024267	REL	ENSAPOP00000024267	ENSAPOP00000003359	RHD domain-containing protein.	REL proto-oncogene, NF-kB subunit.	0.940
ENSAPOP00000024267	ikbkb	ENSAPOP00000024267	ENSAPOP00000003614	RHD domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.931
ENSAPOP00000024267	ikbke	ENSAPOP00000024267	ENSAPOP00000026772	RHD domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.812
ENSAPOP00000024267	ikbkg	ENSAPOP00000024267	ENSAPOP00000006987	RHD domain-containing protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.874