(23 nodes) Mixed, incl. Interleukin receptor SHC signaling, and Spanning component of membrane network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111581338	Uncharacterized protein. (694 aa)
	LOC111579643	Inositol polyphosphate phosphatase-like 1b. (1192 aa)
	ENSAOCP00000004198	Uncharacterized protein. (82 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (494 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (555 aa)
	LOC111565347	GRB2 related adaptor protein a. (225 aa)
	ENSAOCP00000012526	Uncharacterized protein. (199 aa)
	Shc4	SH2 domain-containing protein. (213 aa)
	rasgrf2	Ras protein-specific guanine nucleotide-releasing factor 2b. (1170 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (475 aa)
	LOC111577732	Receptor protein-tyrosine kinase. (1297 aa)
	LOC111579496	Uncharacterized protein. (259 aa)
	LOC111577597	GRB2 related adaptor protein 2b. (258 aa)
	gab2	GRB2-associated binding protein 2. (662 aa)
	LOC111581826	Erb-b2 receptor tyrosine kinase 3b. (1165 aa)
	gab1	GRB2-associated binding protein 1. (756 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1420 aa)
	LOC111574054	Receptor protein-tyrosine kinase. (1250 aa)
	LOC111583377	Ras protein-specific guanine nucleotide-releasing factor 2a. (1180 aa)
	mst1r	Macrophage stimulating 1 receptor b. (1374 aa)
	SHC3	SHC adaptor protein 3. (635 aa)
	ENSAOCP00000031140	UBA domain-containing protein. (159 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAOCP00000004198	ENSAOCP00000012526	ENSAOCP00000004198	ENSAOCP00000012526	Uncharacterized protein.	Uncharacterized protein.	0.655
ENSAOCP00000004198	ENSAOCP00000031140	ENSAOCP00000004198	ENSAOCP00000031140	Uncharacterized protein.	UBA domain-containing protein.	0.721
ENSAOCP00000004198	LOC111565347	ENSAOCP00000004198	ENSAOCP00000009415	Uncharacterized protein.	GRB2 related adaptor protein a.	0.648
ENSAOCP00000004198	LOC111577597	ENSAOCP00000004198	ENSAOCP00000024828	Uncharacterized protein.	GRB2 related adaptor protein 2b.	0.648
ENSAOCP00000004198	LOC111579496	ENSAOCP00000004198	ENSAOCP00000024183	Uncharacterized protein.	Uncharacterized protein.	0.648
ENSAOCP00000004198	LOC111583377	ENSAOCP00000004198	ENSAOCP00000028630	Uncharacterized protein.	Ras protein-specific guanine nucleotide-releasing factor 2a.	0.456
ENSAOCP00000004198	SHC3	ENSAOCP00000004198	ENSAOCP00000030513	Uncharacterized protein.	SHC adaptor protein 3.	0.655
ENSAOCP00000004198	Shc4	ENSAOCP00000004198	ENSAOCP00000012549	Uncharacterized protein.	SH2 domain-containing protein.	0.655
ENSAOCP00000004198	gab1	ENSAOCP00000004198	ENSAOCP00000027051	Uncharacterized protein.	GRB2-associated binding protein 1.	0.703
ENSAOCP00000004198	grb2	ENSAOCP00000004198	ENSAOCP00000031418	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.837
ENSAOCP00000004198	met	ENSAOCP00000004198	ENSAOCP00000028153	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.765
ENSAOCP00000004198	mst1r	ENSAOCP00000004198	ENSAOCP00000029672	Uncharacterized protein.	Macrophage stimulating 1 receptor b.	0.765
ENSAOCP00000004198	ptpn6	ENSAOCP00000004198	ENSAOCP00000005213	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.603
ENSAOCP00000004198	rasgrf2	ENSAOCP00000004198	ENSAOCP00000012814	Uncharacterized protein.	Ras protein-specific guanine nucleotide-releasing factor 2b.	0.456
ENSAOCP00000004198	shc1	ENSAOCP00000004198	ENSAOCP00000021146	Uncharacterized protein.	SHC (Src homology 2 domain containing) transforming protein 1.	0.655
ENSAOCP00000004198	shc2	ENSAOCP00000004198	ENSAOCP00000004366	Uncharacterized protein.	SHC (Src homology 2 domain containing) transforming protein 2.	0.597
ENSAOCP00000012526	ENSAOCP00000004198	ENSAOCP00000012526	ENSAOCP00000004198	Uncharacterized protein.	Uncharacterized protein.	0.655
ENSAOCP00000012526	ENSAOCP00000031140	ENSAOCP00000012526	ENSAOCP00000031140	Uncharacterized protein.	UBA domain-containing protein.	0.440
ENSAOCP00000012526	LOC111565347	ENSAOCP00000012526	ENSAOCP00000009415	Uncharacterized protein.	GRB2 related adaptor protein a.	0.647
ENSAOCP00000012526	LOC111574054	ENSAOCP00000012526	ENSAOCP00000028327	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.655