(12 nodes) Mixed, incl. MET activates RAS signaling, and Spanning component of membrane network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSAOCP00000004198	Uncharacterized protein. (82 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (555 aa)
	LOC111565347	GRB2 related adaptor protein a. (225 aa)
	Shc4	SH2 domain-containing protein. (213 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (475 aa)
	LOC111577732	Receptor protein-tyrosine kinase. (1297 aa)
	LOC111577597	GRB2 related adaptor protein 2b. (258 aa)
	gab1	GRB2-associated binding protein 1. (756 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1420 aa)
	mst1r	Macrophage stimulating 1 receptor b. (1374 aa)
	ENSAOCP00000031140	UBA domain-containing protein. (159 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAOCP00000004198	ENSAOCP00000031140	ENSAOCP00000004198	ENSAOCP00000031140	Uncharacterized protein.	UBA domain-containing protein.	0.721
ENSAOCP00000004198	LOC111565347	ENSAOCP00000004198	ENSAOCP00000009415	Uncharacterized protein.	GRB2 related adaptor protein a.	0.648
ENSAOCP00000004198	LOC111577597	ENSAOCP00000004198	ENSAOCP00000024828	Uncharacterized protein.	GRB2 related adaptor protein 2b.	0.648
ENSAOCP00000004198	Shc4	ENSAOCP00000004198	ENSAOCP00000012549	Uncharacterized protein.	SH2 domain-containing protein.	0.655
ENSAOCP00000004198	gab1	ENSAOCP00000004198	ENSAOCP00000027051	Uncharacterized protein.	GRB2-associated binding protein 1.	0.703
ENSAOCP00000004198	grb2	ENSAOCP00000004198	ENSAOCP00000031418	Uncharacterized protein.	Growth factor receptor-bound protein 2b.	0.837
ENSAOCP00000004198	met	ENSAOCP00000004198	ENSAOCP00000028153	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.765
ENSAOCP00000004198	mst1r	ENSAOCP00000004198	ENSAOCP00000029672	Uncharacterized protein.	Macrophage stimulating 1 receptor b.	0.765
ENSAOCP00000004198	ptpn6	ENSAOCP00000004198	ENSAOCP00000005213	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.603
ENSAOCP00000004198	shc1	ENSAOCP00000004198	ENSAOCP00000021146	Uncharacterized protein.	SHC (Src homology 2 domain containing) transforming protein 1.	0.655
ENSAOCP00000031140	ENSAOCP00000004198	ENSAOCP00000031140	ENSAOCP00000004198	UBA domain-containing protein.	Uncharacterized protein.	0.721
ENSAOCP00000031140	LOC111565347	ENSAOCP00000031140	ENSAOCP00000009415	UBA domain-containing protein.	GRB2 related adaptor protein a.	0.729
ENSAOCP00000031140	LOC111577597	ENSAOCP00000031140	ENSAOCP00000024828	UBA domain-containing protein.	GRB2 related adaptor protein 2b.	0.729
ENSAOCP00000031140	LOC111577732	ENSAOCP00000031140	ENSAOCP00000021158	UBA domain-containing protein.	Receptor protein-tyrosine kinase.	0.721
ENSAOCP00000031140	Shc4	ENSAOCP00000031140	ENSAOCP00000012549	UBA domain-containing protein.	SH2 domain-containing protein.	0.440
ENSAOCP00000031140	grb2	ENSAOCP00000031140	ENSAOCP00000031418	UBA domain-containing protein.	Growth factor receptor-bound protein 2b.	0.936
ENSAOCP00000031140	met	ENSAOCP00000031140	ENSAOCP00000028153	UBA domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.959
ENSAOCP00000031140	mst1r	ENSAOCP00000031140	ENSAOCP00000029672	UBA domain-containing protein.	Macrophage stimulating 1 receptor b.	0.959
ENSAOCP00000031140	ptpn6	ENSAOCP00000031140	ENSAOCP00000005213	UBA domain-containing protein.	Protein tyrosine phosphatase non-receptor type 6.	0.494
ENSAOCP00000031140	shc1	ENSAOCP00000031140	ENSAOCP00000021146	UBA domain-containing protein.	SHC (Src homology 2 domain containing) transforming protein 1.	0.440