(63 nodes) Pancreas development network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111562998	Interleukin 6 receptor. (600 aa)
	LOC111569803	Notch receptor 1a. (2471 aa)
	utp25	UTP25 small subunit processor component. (765 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (78 aa)
	isl1	ISL LIM homeobox 1. (349 aa)
	MYO1D	Myosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (994 aa)
	LOC111565182	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (491 aa)
	IKZF5	IKAROS family zinc finger 5. (417 aa)
	ENSAOCP00000012245	IKAROS family zinc finger 5. (432 aa)
	sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (946 aa)
	ENSAOCP00000010819	Uncharacterized protein. (419 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1106 aa)
	ENSAOCP00000009998	Paired box 4. (299 aa)
	fgfr2	Fibroblast growth factor receptor. (836 aa)
	ptf1a	Pancreas associated transcription factor 1a. (273 aa)
	LOC111562874	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	ENSAOCP00000008060	Achaete-scute family bHLH transcription factor 1b. (186 aa)
	pax6	Paired box 6b. (437 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (556 aa)
	hnf1b	HNF1 homeobox Ba. (573 aa)
	hnf1a	HNF1 homeobox a. (563 aa)
	yap1	Yes-associated protein 1. (438 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (790 aa)
	LOC111586409	Neurogenic differentiation factor. (357 aa)
	nkx6-2	NK6 homeobox 2. (283 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (314 aa)
	LOC111587593	ISL LIM homeobox 2b. (359 aa)
	LOC111582532	Insulin-like growth factor 2b. (215 aa)
	LOC111585214	Neuron navigator 3. (2088 aa)
	ISL2	ISL LIM homeobox 2a. (333 aa)
	arx	Aristaless related homeobox a. (468 aa)
	LOC111586686	NK2 homeobox 2a. (273 aa)
	LOC111574388	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC111572119	Pancreatic progenitor cell differentiation and proliferation factor a. (119 aa)
	CENPA	Centromere protein A. (144 aa)
	LOC111582656	NK2 homeobox 2b. (246 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (823 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
	rfx6	Regulatory factor X, 6. (876 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (411 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1408 aa)
	LOC111579575	Insulinoma-associated 1b. (382 aa)
	LOC111567096	Wolfram syndrome 1a (wolframin). (871 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (978 aa)
	notch1	Notch receptor 1b. (2480 aa)
	nkx6-1	NK6 homeobox 1. (312 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (260 aa)
	LOC111566975	T-box transcription factor Ta. (421 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (519 aa)
	ENSAOCP00000026364	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (56 aa)
	LOC111564721	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (401 aa)
	hhex	Homeobox domain-containing protein. (303 aa)
	ENSAOCP00000028238	Uncharacterized protein. (122 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (276 aa)
	LOC111570352	Betaine-homocysteine methyltransferase. (424 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	LOC111581625	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (372 aa)
	LOC111573926	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (723 aa)
	LOC111576238	Zgc:153993. (205 aa)
	insm1	Insulinoma-associated 1a. (420 aa)
	bmp2	Bone morphogenetic protein 2b. (416 aa)
	LOC111581621	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (367 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CENPA	suv39h1	ENSAOCP00000017600	ENSAOCP00000022196	Centromere protein A.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.677
ENSAOCP00000008060	ISL2	ENSAOCP00000008060	ENSAOCP00000000301	Achaete-scute family bHLH transcription factor 1b.	ISL LIM homeobox 2a.	0.432
ENSAOCP00000008060	LOC111587593	ENSAOCP00000008060	ENSAOCP00000002969	Achaete-scute family bHLH transcription factor 1b.	ISL LIM homeobox 2b.	0.432
ENSAOCP00000008060	isl1	ENSAOCP00000008060	ENSAOCP00000014670	Achaete-scute family bHLH transcription factor 1b.	ISL LIM homeobox 1.	0.432
ENSAOCP00000009998	pdx1	ENSAOCP00000009998	ENSAOCP00000028352	Paired box 4.	Pancreatic and duodenal homeobox 1.	0.496
ENSAOCP00000010819	pdx1	ENSAOCP00000010819	ENSAOCP00000028352	Uncharacterized protein.	Pancreatic and duodenal homeobox 1.	0.496
ENSAOCP00000026364	LOC111582532	ENSAOCP00000026364	ENSAOCP00000002810	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor 2b.	0.410
ENSAOCP00000026364	LOC111582656	ENSAOCP00000026364	ENSAOCP00000018378	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2b.	0.418
ENSAOCP00000026364	LOC111586409	ENSAOCP00000026364	ENSAOCP00000003798	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor.	0.403
ENSAOCP00000026364	LOC111586686	ENSAOCP00000026364	ENSAOCP00000015779	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2a.	0.418
ENSAOCP00000026364	nkx6-1	ENSAOCP00000026364	ENSAOCP00000024384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK6 homeobox 1.	0.414
ENSAOCP00000026364	pcsk1	ENSAOCP00000026364	ENSAOCP00000003853	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.615
ENSAOCP00000026364	pdx1	ENSAOCP00000026364	ENSAOCP00000028352	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.602
ENSAOCP00000026364	ptf1a	ENSAOCP00000026364	ENSAOCP00000008767	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreas associated transcription factor 1a.	0.466
ENSAOCP00000026364	rfx6	ENSAOCP00000026364	ENSAOCP00000021988	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.466
ISL2	ENSAOCP00000008060	ENSAOCP00000000301	ENSAOCP00000008060	ISL LIM homeobox 2a.	Achaete-scute family bHLH transcription factor 1b.	0.432
ISL2	ptf1a	ENSAOCP00000000301	ENSAOCP00000008767	ISL LIM homeobox 2a.	Pancreas associated transcription factor 1a.	0.427
LOC111562874	smo	ENSAOCP00000008687	ENSAOCP00000019058	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.757
LOC111564721	LOC111570352	ENSAOCP00000027871	ENSAOCP00000028768	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	Betaine-homocysteine methyltransferase.	0.901
LOC111564721	LOC111581621	ENSAOCP00000027871	ENSAOCP00000015603	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism.	0.901