(64 nodes) Tissue regeneration network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111571949	Tetraspanin. (228 aa)
	RBBP4	RB binding protein 4, chromatin remodeling factor. (425 aa)
	FAM53B	Family with sequence similarity 53 member B. (442 aa)
	LOC111582028	POU domain protein. (520 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (649 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (202 aa)
	Ninj1	Ninjurin 1. (143 aa)
	yap1	Yes-associated protein 1. (438 aa)
	six6	SIX homeobox 6a. (245 aa)
	tbx5	T-box transcription factor 5a. (525 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (763 aa)
	akirin1	Akirin 1. (194 aa)
	CCN3	Cellular communication network factor 3. (350 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (227 aa)
	ptgfrn	Uncharacterized protein. (883 aa)
	LOC111570011	Interferon-related developmental regulator 2. (327 aa)
	klf5	Progesterone immunomodulatory binding factor 1. (508 aa)
	CD9	Tetraspanin. (228 aa)
	ifrd1	Interferon-related developmental regulator 1. (428 aa)
	larp7	La ribonucleoprotein domain family, member 7. (566 aa)
	LOC111575148	Uncharacterized protein. (153 aa)
	gap43	Growth associated protein 43. (251 aa)
	LOC111572808	Kruppel-like factor 5b. (442 aa)
	gata3	GATA binding protein 3. (439 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	LOC111579728	Growth differentiation factor 11. (388 aa)
	LOC111581680	Beta-1,3-N-acetylglucosaminyltransferase. (373 aa)
	LOC111577897	WD_REPEATS_REGION domain-containing protein. (424 aa)
	LOC111569869	Uncharacterized protein. (251 aa)
	LOC111565160	Uncharacterized protein. (166 aa)
	esco2	Establishment of sister chromatid cohesion N-acetyltransferase 2. (655 aa)
	LOC111576830	SIX homeobox 7. (260 aa)
	LOC111566847	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	ptn	Pleiotrophin. (161 aa)
	tmem182	Transmembrane protein 182a. (248 aa)
	ENSAOCP00000015789	Si:dkey-49n23.1; Belongs to the semaphorin family. (444 aa)
	LOC111574388	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC111573895	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	LOC111572133	Si:ch73-390p7.2. (124 aa)
	ENSAOCP00000017694	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (268 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (916 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LOC111585288	Kruppel-like factor 5 like. (426 aa)
	CPQ	Carboxypeptidase Q. (487 aa)
	ENSAOCP00000018960	Si:dkey-83h2.3. (203 aa)
	ttk	Ttk protein kinase. (1003 aa)
	LOC111587652	Uncharacterized protein. (887 aa)
	axin1	Axin 1. (862 aa)
	tm4sf4	Transmembrane 4 L six family member 4. (202 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (160 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (910 aa)
	LOC111570632	Family with sequence similarity 53 member B. (423 aa)
	LOC111587118	Ninjurin 1. (144 aa)
	LOC111572661	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (183 aa)
	ENSAOCP00000025038	Fibroblast growth factor 2. (117 aa)
	LOC111572897	WD_REPEATS_REGION domain-containing protein. (427 aa)
	bin3	Bridging integrator 3. (253 aa)
	LOC111571065	Fibroblast growth factor receptor. (833 aa)
	LOC111573926	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	LOC111577905	SIX homeobox 3b. (277 aa)
	LOC111588740	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. (918 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (763 aa)
	LOC111565550	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	LOC111567324	SIX homeobox 3a. (294 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD9	ptgfrn	ENSAOCP00000010591	ENSAOCP00000008677	Tetraspanin.	Uncharacterized protein.	0.804
CDH2	ENSAOCP00000017694	ENSAOCP00000020782	ENSAOCP00000017694	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.604
CDH2	LOC111588740	ENSAOCP00000020782	ENSAOCP00000030646	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.901
ENSAOCP00000017694	CDH2	ENSAOCP00000017694	ENSAOCP00000020782	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.604
ENSAOCP00000017694	LOC111588740	ENSAOCP00000017694	ENSAOCP00000030646	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.572
ENSAOCP00000017694	cav1	ENSAOCP00000017694	ENSAOCP00000012998	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.641
ENSAOCP00000017694	ptn	ENSAOCP00000017694	ENSAOCP00000015148	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pleiotrophin.	0.500
ENSAOCP00000017694	tbx5	ENSAOCP00000017694	ENSAOCP00000004913	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	T-box transcription factor 5a.	0.402
ENSAOCP00000025038	LOC111571065	ENSAOCP00000025038	ENSAOCP00000027705	Fibroblast growth factor 2.	Fibroblast growth factor receptor.	0.694
EZH1	LOC111572897	ENSAOCP00000031371	ENSAOCP00000025533	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	WD_REPEATS_REGION domain-containing protein.	0.895
EZH1	LOC111577897	ENSAOCP00000031371	ENSAOCP00000014052	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	WD_REPEATS_REGION domain-containing protein.	0.895
EZH1	RBBP4	ENSAOCP00000031371	ENSAOCP00000000517	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	RB binding protein 4, chromatin remodeling factor.	0.895
LOC111571065	ENSAOCP00000025038	ENSAOCP00000027705	ENSAOCP00000025038	Fibroblast growth factor receptor.	Fibroblast growth factor 2.	0.694
LOC111571065	fgf2	ENSAOCP00000027705	ENSAOCP00000008478	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.825
LOC111571949	ptgfrn	ENSAOCP00000022598	ENSAOCP00000008677	Tetraspanin.	Uncharacterized protein.	0.804
LOC111572897	EZH1	ENSAOCP00000025533	ENSAOCP00000031371	WD_REPEATS_REGION domain-containing protein.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.895
LOC111572897	LOC111577897	ENSAOCP00000025533	ENSAOCP00000014052	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.900
LOC111572897	RBBP4	ENSAOCP00000025533	ENSAOCP00000000517	WD_REPEATS_REGION domain-containing protein.	RB binding protein 4, chromatin remodeling factor.	0.900
LOC111572897	ezh2	ENSAOCP00000025533	ENSAOCP00000005218	WD_REPEATS_REGION domain-containing protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.895
LOC111573895	LOC111587652	ENSAOCP00000016885	ENSAOCP00000019860	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.558