(15 nodes) Vascular endothelial growth factor receptor signaling pathway network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nrp1	Neuropilin; Belongs to the neuropilin family. (917 aa)
	ENSAOCP00000004681	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (130 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (389 aa)
	LOC111572455	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1226 aa)
	LOC111583272	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (237 aa)
	hspb1	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (250 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (422 aa)
	LOC111584551	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (136 aa)
	LOC111583564	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (204 aa)
	LOC111570071	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
	LOC111577456	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSAOCP00000027621	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (292 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	ENSAOCP00000028199	MAPK activated protein kinase 2b. (375 aa)
	LOC111582761	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (167 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAOCP00000004681	ENSAOCP00000027621	ENSAOCP00000004681	ENSAOCP00000027621	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.479
ENSAOCP00000004681	LOC111572455	ENSAOCP00000004681	ENSAOCP00000007905	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.622
ENSAOCP00000004681	LOC111582761	ENSAOCP00000004681	ENSAOCP00000029909	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	0.612
ENSAOCP00000004681	LOC111583272	ENSAOCP00000004681	ENSAOCP00000016817	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	0.478
ENSAOCP00000004681	nrp1	ENSAOCP00000004681	ENSAOCP00000027483	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Neuropilin; Belongs to the neuropilin family.	0.680
ENSAOCP00000004681	vegfb	ENSAOCP00000004681	ENSAOCP00000027940	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.570
ENSAOCP00000004681	vegfc	ENSAOCP00000004681	ENSAOCP00000019850	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.704
ENSAOCP00000027621	ENSAOCP00000004681	ENSAOCP00000027621	ENSAOCP00000004681	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.479
ENSAOCP00000027621	LOC111572455	ENSAOCP00000027621	ENSAOCP00000007905	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.592
ENSAOCP00000027621	LOC111582761	ENSAOCP00000027621	ENSAOCP00000029909	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	0.448
ENSAOCP00000027621	nrp1	ENSAOCP00000027621	ENSAOCP00000027483	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Neuropilin; Belongs to the neuropilin family.	0.501
ENSAOCP00000027621	vegfb	ENSAOCP00000027621	ENSAOCP00000027940	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.497
ENSAOCP00000027621	vegfc	ENSAOCP00000027621	ENSAOCP00000019850	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.721
ENSAOCP00000028199	LOC111583564	ENSAOCP00000028199	ENSAOCP00000024611	MAPK activated protein kinase 2b.	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.	0.872
ENSAOCP00000028199	hspb1	ENSAOCP00000028199	ENSAOCP00000017108	MAPK activated protein kinase 2b.	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.	0.872
LOC111570071	LOC111572455	ENSAOCP00000025172	ENSAOCP00000007905	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.409
LOC111570071	nrp1	ENSAOCP00000025172	ENSAOCP00000027483	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Neuropilin; Belongs to the neuropilin family.	0.409
LOC111572455	ENSAOCP00000004681	ENSAOCP00000007905	ENSAOCP00000004681	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.622
LOC111572455	ENSAOCP00000027621	ENSAOCP00000007905	ENSAOCP00000027621	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.592
LOC111572455	LOC111570071	ENSAOCP00000007905	ENSAOCP00000025172	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.409