(32 nodes) Negative regulation of protein secretion network (Amphiprion ocellaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ENSAOCP00000023963	Sirtuin 4. (155 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	LOC111582546	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	LOC111575966	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (284 aa)
	LOC111563022	Kruppel like factor 7. (301 aa)
	ENSAOCP00000004655	Motilin_assoc domain-containing protein. (121 aa)
	LOC111567783	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	LOC111575348	3-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
	LOC111567081	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (318 aa)
	LOC111565955	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	CCN3	Cellular communication network factor 3. (350 aa)
	chga	Chromogranin A. (330 aa)
	LOC111582404	Rhomboid 5 homolog 1b (Drosophila). (854 aa)
	ENSAOCP00000007361	G_PROTEIN_RECEP_F1_2 domain-containing protein. (65 aa)
	ndufaf2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (162 aa)
	LOC111578733	Ubiquitin-like domain-containing protein. (200 aa)
	kcnj8	Potassium inwardly-rectifying channel, subfamily J, member 8. (419 aa)
	LOC111579328	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	LOC111572335	Ubiquitin-like domain-containing protein. (481 aa)
	pim3	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (331 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (311 aa)
	LOC111572634	Si:dkey-163m14.2. (439 aa)
	rhbdf1	Rhomboid 5 homolog 1a (Drosophila). (779 aa)
	LOC111573119	Uncharacterized protein. (234 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	LOC111562605	Uncharacterized protein. (260 aa)
	RHBDF2	Rhomboid 5 homolog 2. (836 aa)
	sergef	Secretion regulating guanine nucleotide exchange factor. (407 aa)
	LOC111572701	Kruppel-like factor 7b. (309 aa)
	Kcnj11	Potassium inwardly-rectifying channel, subfamily J, member 11. (369 aa)
	midn	Midnolin. (547 aa)
	ENSAOCP00000032068	annotation not available (65 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAOCP00000004655	LOC111565955	ENSAOCP00000004655	ENSAOCP00000006074	Motilin_assoc domain-containing protein.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.527
ENSAOCP00000004655	chga	ENSAOCP00000004655	ENSAOCP00000006406	Motilin_assoc domain-containing protein.	Chromogranin A.	0.590
ENSAOCP00000007361	LOC111565955	ENSAOCP00000007361	ENSAOCP00000006074	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.538
ENSAOCP00000032068	LOC111565955	ENSAOCP00000032068	ENSAOCP00000006074	annotation not available	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.538
Kcnj11	sergef	ENSAOCP00000030592	ENSAOCP00000027859	Potassium inwardly-rectifying channel, subfamily J, member 11.	Secretion regulating guanine nucleotide exchange factor.	0.561
LOC111565955	ENSAOCP00000004655	ENSAOCP00000006074	ENSAOCP00000004655	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Motilin_assoc domain-containing protein.	0.527
LOC111565955	ENSAOCP00000007361	ENSAOCP00000006074	ENSAOCP00000007361	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.538
LOC111565955	ENSAOCP00000032068	ENSAOCP00000006074	ENSAOCP00000032068	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	annotation not available	0.538
LOC111565955	LOC111567783	ENSAOCP00000006074	ENSAOCP00000004696	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.538
LOC111565955	LOC111575966	ENSAOCP00000006074	ENSAOCP00000003789	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.538
LOC111565955	LOC111582546	ENSAOCP00000006074	ENSAOCP00000002455	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	0.538
LOC111567783	LOC111565955	ENSAOCP00000004696	ENSAOCP00000006074	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.538
LOC111575348	LOC111579328	ENSAOCP00000005284	ENSAOCP00000011695	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC111575966	LOC111565955	ENSAOCP00000003789	ENSAOCP00000006074	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.538
LOC111579328	LOC111575348	ENSAOCP00000011695	ENSAOCP00000005284	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC111582546	LOC111565955	ENSAOCP00000002455	ENSAOCP00000006074	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.538
chga	ENSAOCP00000004655	ENSAOCP00000006406	ENSAOCP00000004655	Chromogranin A.	Motilin_assoc domain-containing protein.	0.590
kcnj8	sergef	ENSAOCP00000010111	ENSAOCP00000027859	Potassium inwardly-rectifying channel, subfamily J, member 8.	Secretion regulating guanine nucleotide exchange factor.	0.431
sergef	Kcnj11	ENSAOCP00000027859	ENSAOCP00000030592	Secretion regulating guanine nucleotide exchange factor.	Potassium inwardly-rectifying channel, subfamily J, member 11.	0.561
sergef	kcnj8	ENSAOCP00000027859	ENSAOCP00000010111	Secretion regulating guanine nucleotide exchange factor.	Potassium inwardly-rectifying channel, subfamily J, member 8.	0.431