(24 nodes) Regulation of cardiac muscle contraction network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111575340	Uncharacterized protein. (475 aa)
	sri	Uncharacterized protein. (184 aa)
	LOC111565860	Uncharacterized protein. (247 aa)
	ENSAOCP00000010121	Uncharacterized protein. (259 aa)
	ankrd52	Ankyrin repeat domain 52a. (1077 aa)
	pkd2	Polycystic kidney disease 2. (903 aa)
	LOC111581503	PKD_channel domain-containing protein. (513 aa)
	LOC111582920	Uncharacterized protein. (750 aa)
	nkx2-5	NK2 homeobox 5. (319 aa)
	LOC111566303	Junction plakoglobin a. (749 aa)
	RNF207	Ring finger protein 207. (581 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (631 aa)
	LOC111573357	ANK_REP_REGION domain-containing protein. (1101 aa)
	ankrd66	Ankyrin repeat domain 66. (166 aa)
	LOC111579732	ANK_REP_REGION domain-containing protein. (988 aa)
	ucn	Urotensin 1. (148 aa)
	pln	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
	LOC111588832	Ankyrin repeat domain 28b. (1052 aa)
	ankrd44	Ankyrin repeat domain 44. (986 aa)
	LOC111585766	Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (440 aa)
	LOC111585045	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (391 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	LOC111575501	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111566303	LOC111575501	ENSAOCP00000030301	ENSAOCP00000001527	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.528
LOC111566303	cav3	ENSAOCP00000030301	ENSAOCP00000001520	Junction plakoglobin a.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.417
LOC111575501	LOC111566303	ENSAOCP00000001527	ENSAOCP00000030301	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.528
LOC111575501	LOC111582920	ENSAOCP00000001527	ENSAOCP00000026884	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.528
LOC111575501	cav3	ENSAOCP00000001527	ENSAOCP00000001520	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.610
LOC111582920	LOC111575501	ENSAOCP00000026884	ENSAOCP00000001527	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.528
LOC111582920	cav3	ENSAOCP00000026884	ENSAOCP00000001520	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.417
LOC111585045	nkx2-5	ENSAOCP00000022232	ENSAOCP00000027066	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.441
cav3	LOC111566303	ENSAOCP00000001520	ENSAOCP00000030301	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.417
cav3	LOC111575501	ENSAOCP00000001520	ENSAOCP00000001527	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.610
cav3	LOC111582920	ENSAOCP00000001520	ENSAOCP00000026884	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.417
gja5	nkx2-5	ENSAOCP00000004627	ENSAOCP00000027066	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.441
nkx2-5	LOC111585045	ENSAOCP00000027066	ENSAOCP00000022232	NK2 homeobox 5.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.441
nkx2-5	gja5	ENSAOCP00000027066	ENSAOCP00000004627	NK2 homeobox 5.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.441