STRINGSTRING
sfrp2 sfrp2 spry1 spry1 flcn flcn Nog Nog vwc2l vwc2l sp9 sp9 LOC111562874 LOC111562874 sulf1 sulf1 LOC111574206 LOC111574206 htra3 htra3 smad7 smad7 zeb1 zeb1 LOC111568827 LOC111568827 agt agt LOC111579831 LOC111579831 cyfip2 cyfip2 ctdspl2 ctdspl2 LOC111588045 LOC111588045 itga3 itga3 LOC111588070 LOC111588070 LOC111565279 LOC111565279 LOC111564110 LOC111564110 cemip2 cemip2 ENSAOCP00000011442 ENSAOCP00000011442 numa1 numa1 LOC111570888 LOC111570888 LOC111572309 LOC111572309 fgf4 fgf4 sorl1 sorl1 hif1an hif1an LOC111576736 LOC111576736 LOC111563069 LOC111563069 LOC111587227 LOC111587227 foxh1 foxh1 cd63 cd63 grem2 grem2 LOC111576637 LOC111576637 pin1 pin1 prdm16 prdm16 LOC111567907 LOC111567907 hjv hjv LOC111587893 LOC111587893 fgfbp3 fgfbp3 chrdl2 chrdl2 fstl3 fstl3 bmp2 bmp2 fgf16 fgf16 LOC111566805 LOC111566805 LOC111574796 LOC111574796 bambi bambi inppl1 inppl1 bmper bmper LOC111585787 LOC111585787 snw1 snw1 sfrp5 sfrp5 tmem108 tmem108 vwc2 vwc2 LOC111580077 LOC111580077 LOC111575501 LOC111575501 cav3 cav3 LOC111588848 LOC111588848 LOC111573159 LOC111573159 LOC111573682 LOC111573682 skor1 skor1 smad6 smad6 hhip hhip ccn1 ccn1 gdf5 gdf5 LOC111574955 LOC111574955 tll1 tll1 LOC111588210 LOC111588210 LOC111563679 LOC111563679 nrros nrros men1 men1 LOC111588173 LOC111588173 SPRY3 SPRY3 LOC111582895 LOC111582895 LOC111568760 LOC111568760 LOC111583436 LOC111583436 LOC111574097 LOC111574097 LOC111564054 LOC111564054 LOC111565189 LOC111565189 LOC111566051 LOC111566051 tmem204 tmem204 LOC111571060 LOC111571060 LOC111585430 LOC111585430 LOC111569890 LOC111569890 LOC111567532 LOC111567532 lemd3 lemd3 LOC111568685 LOC111568685 wfikkn2 wfikkn2 LOC111568681 LOC111568681 LOC111571013 LOC111571013 gpc1 gpc1 bmp4 bmp4 ENSAOCP00000014497 ENSAOCP00000014497 hsp90ab1 hsp90ab1 LOC111570317 LOC111570317 LOC111588778 LOC111588778 GREM1 GREM1 LOC111578529 LOC111578529 LOC111582784 LOC111582784 LOC111574400 LOC111574400 LOC111584666 LOC111584666 SMAD4 SMAD4 LOC111574397 LOC111574397 LOC111577007 LOC111577007 LOC111566818 LOC111566818 sostdc1 sostdc1 fzd4 fzd4 LOC111585884 LOC111585884 IL12B IL12B lats1 lats1 pbld pbld fam89b fam89b smurf1 smurf1 ENSAOCP00000017634 ENSAOCP00000017634 skor2 skor2 LOC111585325 LOC111585325 LOC111585318 LOC111585318 bcl9l bcl9l skil skil ENSAOCP00000018437 ENSAOCP00000018437 CASK CASK twsg1 twsg1 LOC111570811 LOC111570811 LOC111575547 LOC111575547 shisa2 shisa2 ENSAOCP00000019290 ENSAOCP00000019290 cunh20orf27 cunh20orf27 prdm14 prdm14 LOC111588910 LOC111588910 LOC111580155 LOC111580155 LOC111581422 LOC111581422 vegfc vegfc LOC111581403 LOC111581403 hgs hgs znf451 znf451 LOC111578329 LOC111578329 NOG NOG sirt1 sirt1 LOC111587601 LOC111587601 LOC111575429 LOC111575429 ENSAOCP00000021293 ENSAOCP00000021293 ENSAOCP00000021299 ENSAOCP00000021299 shh shh spred3 spred3 fst fst LOC111563068 LOC111563068 tdp2 tdp2 LOC111578222 LOC111578222 ENSAOCP00000022086 ENSAOCP00000022086 LOC111577713 LOC111577713 dab2 dab2 LOC111585302 LOC111585302 ENSAOCP00000023028 ENSAOCP00000023028 dcn dcn LOC111565930 LOC111565930 myocd myocd strap strap UBE2O UBE2O LOC111573493 LOC111573493 ENSAOCP00000024642 ENSAOCP00000024642 LOC111588656 LOC111588656 bmpr2 bmpr2 LOC111581848 LOC111581848 LOC111570071 LOC111570071 LOC111562881 LOC111562881 LOC111566823 LOC111566823 SMURF2 SMURF2 LOC111566975 LOC111566975 churc1 churc1 LOC111562846 LOC111562846 hspa5 hspa5 chrd chrd Wfikkn1 Wfikkn1 tspan12 tspan12 LOC111579811 LOC111579811 LOC111577456 LOC111577456 LOC111584149 LOC111584149 stk11 stk11 supt5h supt5h LOC111581736 LOC111581736 nrp1 nrp1 lats2 lats2 snx25 snx25 tnfaip6 tnfaip6 LOC111568052 LOC111568052 tgfbr3 tgfbr3 LOC111580941 LOC111580941 LOC111575674 LOC111575674 LOC111588427 LOC111588427 LOC111582166 LOC111582166 LOC111569800 LOC111569800 LOC111571663 LOC111571663 LOC111567447 LOC111567447 lrit3 lrit3 il17rd il17rd LOC111577719 LOC111577719 LOC111581982 LOC111581982 LOC111582511 LOC111582511 NBL1 NBL1 LOC111578213 LOC111578213 ENSAOCP00000004320 ENSAOCP00000004320 msx1 msx1 spart spart spry4 spry4 ILK ILK fbxl15 fbxl15 LOC111588236 LOC111588236 ENSAOCP00000005707 ENSAOCP00000005707 adamtsl2 adamtsl2 fkbp8 fkbp8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sfrp2Secreted frizzled-related protein 2. (301 aa)
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (362 aa)
flcnFolliculin. (358 aa)
NogNoggin; Belongs to the noggin family. (216 aa)
vwc2lVon Willebrand factor C domain containing 2 like. (231 aa)
sp9Sp9 transcription factor. (439 aa)
LOC111562874Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
sulf1Extracellular sulfatase. (872 aa)
LOC111574206UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5. (381 aa)
htra3HtrA serine peptidase 3. (468 aa)
smad7Mothers against decapentaplegic homolog. (376 aa)
zeb1Zinc finger E-box binding homeobox 1b. (1096 aa)
LOC111568827SKI family transcriptional corepressor 1. (761 aa)
agtAngiotensinogen; Belongs to the serpin family. (464 aa)
LOC111579831Protein tyrosine phosphatase 4A3b. (178 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ctdspl2CTD small phosphatase like 2. (477 aa)
LOC111588045Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
itga3Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1075 aa)
LOC111588070Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
LOC111565279Mothers against decapentaplegic homolog. (505 aa)
LOC111564110Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (760 aa)
cemip2Cell migration inducing hyaluronidase 2. (1390 aa)
ENSAOCP00000011442Uncharacterized protein. (311 aa)
numa1Uncharacterized protein. (2296 aa)
LOC111570888Secreted frizzled-related protein 2 like. (341 aa)
LOC111572309Ig-like domain-containing protein. (622 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats containing. (2098 aa)
hif1anHypoxia inducible factor 1 subunit alpha inhibitor. (354 aa)
LOC111576736HtrA serine peptidase 3a. (453 aa)
LOC111563069C-X-C motif chemokine. (106 aa)
LOC111587227ADAM metallopeptidase domain 17b. (866 aa)
foxh1Forkhead box H1. (516 aa)
cd63Tetraspanin. (240 aa)
grem2Gremlin 2, DAN family BMP antagonist a. (190 aa)
LOC111576637Cell death inducing DFFA like effector a. (211 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (156 aa)
prdm16Si:ch211-263k4.2. (1316 aa)
LOC111567907E3 ubiquitin-protein ligase. (770 aa)
hjvHemojuvelin BMP co-receptor. (420 aa)
LOC111587893Mothers against decapentaplegic homolog. (551 aa)
fgfbp3Fibroblast growth factor binding protein 3. (241 aa)
chrdl2Chordin-like 2. (440 aa)
fstl3Follistatin-like 3 (secreted glycoprotein). (248 aa)
bmp2Bone morphogenetic protein 2b. (416 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
LOC111566805Growth differentiation factor 6a. (422 aa)
LOC111574796Interleukin 17a/f1. (160 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
inppl1Inositol polyphosphate phosphatase-like 1a. (1256 aa)
bmperBMP binding endothelial regulator. (693 aa)
LOC111585787Peptidylprolyl isomerase. (467 aa)
snw1SNW domain containing 1. (538 aa)
sfrp5Secreted frizzled-related protein 5. (321 aa)
tmem108Transmembrane protein 108. (522 aa)
vwc2Von Willebrand factor C domain containing 2. (311 aa)
LOC111580077GIPC PDZ domain containing family, member 3. (334 aa)
LOC111575501Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
LOC111588848Sp8 transcription factor b. (452 aa)
LOC111573159Sizzled. (283 aa)
LOC111573682GIPC PDZ domain containing family, member 1. (337 aa)
skor1SKI family transcriptional corepressor 1b. (742 aa)
smad6Mothers against decapentaplegic homolog. (488 aa)
hhipHedgehog interacting protein. (698 aa)
ccn1Cellular communication network factor 1. (376 aa)
gdf5Growth differentiation factor 5. (544 aa)
LOC111574955Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (188 aa)
tll1Metalloendopeptidase. (915 aa)
LOC111588210Fam20C domain-containing protein. (558 aa)
LOC111563679Spartin b. (592 aa)
nrrosNegative regulator of reactive oxygen species. (680 aa)
men1Multiple endocrine neoplasia I. (624 aa)
LOC111588173Noggin; Belongs to the noggin family. (211 aa)
SPRY3Sprouty RTK signaling antagonist 3. (299 aa)
LOC111582895Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
LOC111568760Ubiquitin-like protein. (117 aa)
LOC111583436Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (942 aa)
LOC111574097DAN domain family, member 5. (251 aa)
LOC111564054Golgi glycoprotein 1a. (1144 aa)
LOC111565189Mothers against decapentaplegic homolog. (476 aa)
LOC111566051Uncharacterized protein. (452 aa)
tmem204Transmembrane protein 204. (226 aa)
LOC111571060Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family. (422 aa)
LOC111585430V-ski avian sarcoma viral oncogene homolog b. (692 aa)
LOC111569890CREB binding protein a. (2477 aa)
LOC111567532Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (874 aa)
lemd3LEM domain containing 3. (859 aa)
LOC111568685Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
wfikkn2Info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a. (579 aa)
LOC111568681Si:ch211-207e14.4. (598 aa)
LOC111571013Elastin microfibril interfacer 1b. (1225 aa)
gpc1Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (550 aa)
bmp4Bone morphogenetic protein 4. (403 aa)
ENSAOCP00000014497Uncharacterized protein. (253 aa)
hsp90ab1Heat shock protein 90, alpha (cytosolic), class B member 1. (725 aa)
LOC111570317E1A binding protein p300 b. (2806 aa)
LOC111588778Low density lipoprotein receptor class A domain containing 4b. (297 aa)
GREM1Gremlin. (182 aa)
LOC111578529RGM domain family, member D. (463 aa)
LOC111582784CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3. (378 aa)
LOC111574400WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b. (571 aa)
LOC111584666ZP domain-containing protein. (660 aa)
SMAD4Mothers against decapentaplegic homolog. (503 aa)
LOC111574397E1A binding protein p300 a. (2809 aa)
LOC111577007Mothers against decapentaplegic homolog. (510 aa)
LOC111566818Canopy FGF signaling regulator 1. (186 aa)
sostdc1Sclerostin domain containing 1a. (217 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
LOC111585884Uncharacterized protein. (233 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (311 aa)
lats1Large tumor suppressor kinase 1. (1103 aa)
pbldPhenazine biosynthesis like protein domain containing. (294 aa)
fam89bFamily with sequence similarity 89 member B. (177 aa)
smurf1E3 ubiquitin-protein ligase. (727 aa)
ENSAOCP00000017634BPTI/Kunitz inhibitor domain-containing protein. (159 aa)
skor2SKI family transcriptional corepressor 2. (788 aa)
LOC111585325Uncharacterized protein. (160 aa)
LOC111585318Elastin microfibril interfacer 1a. (1057 aa)
bcl9lBcl9 like. (1523 aa)
skilSKI-like proto-oncogene a. (764 aa)
ENSAOCP00000018437Multimerin 2a. (874 aa)
CASKUncharacterized protein; Belongs to the MAGUK family. (889 aa)
twsg1Twisted gastrulation BMP signaling modulator 1. (223 aa)
LOC111570811Bone morphogenetic protein 16. (512 aa)
LOC111575547Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
shisa2Shisa family member 2b. (289 aa)
ENSAOCP00000019290Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
cunh20orf27Si:ch211-74f19.2. (174 aa)
prdm14PR domain containing 14. (605 aa)
LOC111588910Nerve growth factor receptor a (TNFR superfamily, member 16). (399 aa)
LOC111580155C2H2-type domain-containing protein. (598 aa)
LOC111581422Muscle segment homeobox 3. (255 aa)
vegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (422 aa)
LOC111581403Zinc finger protein 703. (591 aa)
hgsHepatocyte growth factor-regulated tyrosine kinase substrate. (766 aa)
znf451Zinc finger protein 451. (879 aa)
LOC111578329Secreted frizzled-related protein 1a. (306 aa)
NOGNoggin; Belongs to the noggin family. (211 aa)
sirt1Sirtuin 1. (695 aa)
LOC111587601Uncharacterized protein. (390 aa)
LOC111575429Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (941 aa)
ENSAOCP00000021293Uncharacterized protein. (111 aa)
ENSAOCP00000021299Uncharacterized protein. (118 aa)
shhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
spred3Sprouty related EVH1 domain containing 3. (523 aa)
fstFollistatin a. (348 aa)
LOC111563068SCY domain-containing protein. (106 aa)
tdp2Tyrosyl-DNA phosphodiesterase 2b. (361 aa)
LOC111578222Si:rp71-46j2.7. (577 aa)
ENSAOCP00000022086Uncharacterized protein. (611 aa)
LOC111577713FCP1 homology domain-containing protein. (474 aa)
dab2DAB adaptor protein 2. (792 aa)
LOC111585302Sclerostin domain containing 1b. (214 aa)
ENSAOCP00000023028V-ski avian sarcoma viral oncogene homolog a. (284 aa)
dcnDecorin; May affect the rate of fibrils formation. (441 aa)
LOC111565930ADAM metallopeptidase domain 17a. (875 aa)
myocdSAP domain-containing protein. (1047 aa)
strapSerine/threonine kinase receptor associated protein. (329 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1203 aa)
LOC111573493Ring finger protein 165b. (350 aa)
ENSAOCP00000024642Uncharacterized protein. (1347 aa)
LOC111588656Uncharacterized protein. (860 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (977 aa)
LOC111581848Zinc finger E-box binding homeobox 2a. (1202 aa)
LOC111570071Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
LOC111562881Uncharacterized protein. (1147 aa)
LOC111566823Uncharacterized protein. (323 aa)
SMURF2E3 ubiquitin-protein ligase. (775 aa)
LOC111566975T-box transcription factor Ta. (421 aa)
churc1Churchill domain containing 1. (94 aa)
LOC111562846Sprouty RTK signaling antagonist 2. (353 aa)
hspa5Heat shock protein 5; Belongs to the heat shock protein 70 family. (654 aa)
chrdChordin; Belongs to the chordin family. (979 aa)
Wfikkn1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (505 aa)
tspan12Tetraspanin. (309 aa)
LOC111579811Metalloendopeptidase. (970 aa)
LOC111577456Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC111584149Leucine rich repeat and Ig domain containing 3a. (610 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (430 aa)
supt5hTranscription elongation factor SPT5. (1062 aa)
LOC111581736Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
nrp1Neuropilin; Belongs to the neuropilin family. (917 aa)
lats2Large tumor suppressor kinase 2. (1151 aa)
snx25Sorting nexin 25. (976 aa)
tnfaip6Tumor necrosis factor, alpha-induced protein 6. (266 aa)
LOC111568052Extracellular sulfatase. (875 aa)
tgfbr3Transforming growth factor, beta receptor III. (807 aa)
LOC111580941Mothers against decapentaplegic homolog. (616 aa)
LOC111575674Gremlin 1a, DAN family BMP antagonist. (179 aa)
LOC111588427Fam20C domain-containing protein. (559 aa)
LOC111582166Si:ch211-267e7.3. (943 aa)
LOC111569800Ring finger protein 165a. (345 aa)
LOC111571663Neuroplastin b. (395 aa)
LOC111567447Glypican 1a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (541 aa)
lrit3Info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a. (639 aa)
il17rdInterleukin 17 receptor D. (655 aa)
LOC111577719Si:ch73-330k17.3. (222 aa)
LOC111581982Golgi glycoprotein 1b. (1140 aa)
LOC111582511CREB binding protein b. (2425 aa)
NBL1NBL1, DAN family BMP antagonist. (189 aa)
LOC111578213FAM20C golgi associated secretory pathway kinase a. (571 aa)
ENSAOCP00000004320Uncharacterized protein. (130 aa)
msx1Muscle segment homeobox 1a. (283 aa)
spartSpartin a. (549 aa)
spry4Sprouty homolog 4 (Drosophila). (293 aa)
ILKIntegrin linked kinase. (452 aa)
fbxl15F-box and leucine-rich repeat protein 15. (291 aa)
LOC111588236Zinc finger E-box binding homeobox 2b. (1216 aa)
ENSAOCP00000005707HATPase_c domain-containing protein. (199 aa)
adamtsl2ADAMTS-like 2. (874 aa)
fkbp8Peptidylprolyl isomerase. (404 aa)
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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