(56 nodes) Hedgehog signaling pathway network (Amphiprion ocellaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	csnk1g2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (448 aa)
	hhip	Hedgehog interacting protein. (698 aa)
	csnk1e	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	LOC111588895	Speckle type BTB/POZ protein. (374 aa)
	gli3	GLI family zinc finger 3. (1550 aa)
	LOC111580119	Uncharacterized protein. (722 aa)
	ptch1	Patched 1. (1570 aa)
	LOC111566117	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	LOC111579002	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	SPOP	Speckle type BTB/POZ protein. (374 aa)
	LOC111563032	Arrestin, beta 1. (422 aa)
	EVC2	EvC ciliary complex subunit 2. (1368 aa)
	LOC111586379	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	LOC111575375	Uncharacterized protein. (167 aa)
	ENSAOCP00000004923	Growth arrest-specific 1b. (258 aa)
	boc	BOC cell adhesion associated, oncogene regulated. (1079 aa)
	ENSAOCP00000005646	Uncharacterized protein. (254 aa)
	LOC111588684	Uncharacterized protein. (216 aa)
	LOC111579931	BCL2 apoptosis regulator b. (228 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (414 aa)
	LOC111562874	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	LOC111571202	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (469 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	sufu	Suppressor of fused homolog. (471 aa)
	ptch2	Patched 2. (1221 aa)
	LOC111577932	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
	LOC111577345	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	LOC111571598	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (414 aa)
	ENSAOCP00000016161	Cyclin D2, a; Belongs to the cyclin family. (177 aa)
	mgrn1	Mahogunin, ring finger 1b. (549 aa)
	gli2	GLI family zinc finger 2a. (1521 aa)
	smurf1	E3 ubiquitin-protein ligase. (727 aa)
	cdon	Cell adhesion associated, oncogene regulated. (1127 aa)
	LOC111576176	Uncharacterized protein. (167 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (823 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	kif3a	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
	LOC111573654	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	kif7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1363 aa)
	LOC111579028	CULLIN_2 domain-containing protein; Belongs to the cullin family. (767 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
	gpr161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (557 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	csnk1a1	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
	spopl	Speckle type BTB/POZ protein like b. (392 aa)
	LOC111586232	Arrestin_C domain-containing protein. (407 aa)
	LOC111564191	Arrestin_C domain-containing protein. (439 aa)
	SMURF2	E3 ubiquitin-protein ligase. (775 aa)
	LOC111566641	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
	LOC111572740	Cyclin Dx; Belongs to the cyclin family. (311 aa)
	LOC111582838	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
	lrp2	Low density lipoprotein receptor-related protein 2a. (4599 aa)
	ccnd2	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	LOC111567907	E3 ubiquitin-protein ligase. (770 aa)
	LOC111580255	Growth arrest-specific 1a. (258 aa)

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK1D	LOC111566117	ENSAOCP00000006946	ENSAOCP00000001745	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.900
CSNK1D	LOC111566641	ENSAOCP00000006946	ENSAOCP00000025801	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
CSNK1D	LOC111573654	ENSAOCP00000006946	ENSAOCP00000020099	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.728
CSNK1D	LOC111577932	ENSAOCP00000006946	ENSAOCP00000014462	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	0.728
CSNK1D	LOC111579002	ENSAOCP00000006946	ENSAOCP00000002009	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.728
CSNK1D	LOC111586379	ENSAOCP00000006946	ENSAOCP00000004649	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.728
CSNK1D	csnk1a1	ENSAOCP00000006946	ENSAOCP00000024210	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.571
CSNK1D	fbxw11	ENSAOCP00000006946	ENSAOCP00000011347	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	F-box and WD repeat domain containing 11a.	0.727
CSNK1D	gsk3b	ENSAOCP00000006946	ENSAOCP00000024115	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.478
CSNK1D	smo	ENSAOCP00000006946	ENSAOCP00000019058	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.906
CUL3	ENSAOCP00000016161	ENSAOCP00000019142	ENSAOCP00000016161	Cullin 3; Belongs to the cullin family.	Cyclin D2, a; Belongs to the cyclin family.	0.615
CUL3	LOC111572740	ENSAOCP00000019142	ENSAOCP00000028525	Cullin 3; Belongs to the cullin family.	Cyclin Dx; Belongs to the cyclin family.	0.556
CUL3	LOC111579028	ENSAOCP00000019142	ENSAOCP00000020494	Cullin 3; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
CUL3	LOC111580119	ENSAOCP00000019142	ENSAOCP00000001039	Cullin 3; Belongs to the cullin family.	Uncharacterized protein.	0.949
CUL3	LOC111588895	ENSAOCP00000019142	ENSAOCP00000000595	Cullin 3; Belongs to the cullin family.	Speckle type BTB/POZ protein.	0.990
CUL3	SPOP	ENSAOCP00000019142	ENSAOCP00000003036	Cullin 3; Belongs to the cullin family.	Speckle type BTB/POZ protein.	0.990
CUL3	ccnd1	ENSAOCP00000019142	ENSAOCP00000030477	Cullin 3; Belongs to the cullin family.	Cyclin D1; Belongs to the cyclin family.	0.615
CUL3	ccnd2	ENSAOCP00000019142	ENSAOCP00000030329	Cullin 3; Belongs to the cullin family.	Cyclin D2, b; Belongs to the cyclin family.	0.615
CUL3	csnk1a1	ENSAOCP00000019142	ENSAOCP00000024210	Cullin 3; Belongs to the cullin family.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.618
CUL3	fbxw11	ENSAOCP00000019142	ENSAOCP00000011347	Cullin 3; Belongs to the cullin family.	F-box and WD repeat domain containing 11a.	0.958