(55 nodes) Purine nucleoside monophosphate metabolic process, and Uridine-diphosphatase activity network (Oreochromis niloticus)

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	I3IWX2_ORENI	Ectonucleoside triphosphate diphosphohydrolase 5b; Belongs to the GDA1/CD39 NTPase family. (243 aa)
	atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
	NT5E	5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family. (584 aa)
	cmpk2	Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial. (421 aa)
	cant1	Calcium activated nucleotidase 1a. (427 aa)
	LOC100693789	5'-nucleotidase, cytosolic IB b. (363 aa)
	nt5c3a	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (337 aa)
	entpd3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (497 aa)
	ENSONIP00000010756	Adenylosuccinate lyase. (507 aa)
	nudt16	Zgc:103759. (219 aa)
	dck	Deoxycytidine kinase. (263 aa)
	entpd4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (621 aa)
	LOC100708436	5'-nucleotidase, cytosolic IAb. (371 aa)
	LOC100702364	GMP reductase 2. (361 aa)
	LOC100705170	Deoxyguanosine kinase. (316 aa)
	nudt12	Nudix (nucleoside diphosphate linked moiety X)-type motif 12. (456 aa)
	LOC100698553	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (212 aa)
	LOC102078803	Calcium activated nucleotidase 1b. (457 aa)
	nt5c2	5'-nucleotidase, cytosolic IIb. (563 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (229 aa)
	LOC100704637	Ectonucleoside triphosphate diphosphohydrolase 5a; Belongs to the GDA1/CD39 NTPase family. (504 aa)
	Dctpp1	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (151 aa)
	entpd6	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (461 aa)
	LOC100691320	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (466 aa)
	pde1b	Phosphodiesterase. (526 aa)
	guk1	Guanylate kinase 1a. (207 aa)
	pde1a	Phosphodiesterase. (812 aa)
	I3KR69_ORENI	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (605 aa)
	LOC100702443	5'-nucleotidase, cytosolic IAa. (388 aa)
	gmpr	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (357 aa)
	aprt	Adenine phosphoribosyltransferase. (181 aa)
	hprt1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	LOC100697636	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (791 aa)
	gmps	Guanine monophosphate synthase. (704 aa)
	I3JRP1_ORENI	Uncharacterized protein. (583 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (350 aa)
	LOC100693341	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (611 aa)
	LOC100698595	Cytosolic 5'-nucleotidase 1B. (259 aa)
	LOC100712431	Phosphodiesterase. (751 aa)
	adss1	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (468 aa)
	LOC100692415	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (949 aa)
	LOC100701529	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (625 aa)
	I3J047_ORENI	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (517 aa)
	ampd1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (745 aa)
	itpa	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (206 aa)
	ampd3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (779 aa)
	LOC100709506	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (840 aa)
	impdh2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (565 aa)
	LOC100701070	Guanylate kinase 1b. (261 aa)
	cmpk1	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (219 aa)
	I3JPG0_ORENI	Adenylosuccinate lyase. (53 aa)
	LOC100698477	5'-nucleotidase, cytosolic II, like 1. (510 aa)
	entpd1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (499 aa)
	LOC109194363	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (502 aa)
	NT5C3B-2	Cytosolic 5'-nucleotidase 3. (333 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dctpp1	I3JRP1_ORENI	ENSONIP00000026584	ENSONIP00000047342	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Uncharacterized protein.	0.900
Dctpp1	I3KR69_ORENI	ENSONIP00000026584	ENSONIP00000040246	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.901
Dctpp1	LOC100693789	ENSONIP00000026584	ENSONIP00000007411	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase, cytosolic IB b.	0.914
Dctpp1	LOC100698477	ENSONIP00000026584	ENSONIP00000076925	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase, cytosolic II, like 1.	0.900
Dctpp1	LOC100698595	ENSONIP00000026584	ENSONIP00000051933	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Cytosolic 5'-nucleotidase 1B.	0.900
Dctpp1	LOC100702443	ENSONIP00000026584	ENSONIP00000040840	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase, cytosolic IAa.	0.914
Dctpp1	LOC100705170	ENSONIP00000026584	ENSONIP00000016787	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Deoxyguanosine kinase.	0.912
Dctpp1	LOC100708436	ENSONIP00000026584	ENSONIP00000015423	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase, cytosolic IAb.	0.914
Dctpp1	NT5C3B	ENSONIP00000026584	ENSONIP00000047421	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.902
Dctpp1	NT5C3B-2	ENSONIP00000026584	ENSONIP00000079225	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Cytosolic 5'-nucleotidase 3.	0.902
Dctpp1	NT5E	ENSONIP00000026584	ENSONIP00000004575	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family.	0.901
Dctpp1	NT5M	ENSONIP00000026584	ENSONIP00000024724	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5',3'-nucleotidase, mitochondrial.	0.902
Dctpp1	cmpk1	ENSONIP00000026584	ENSONIP00000074525	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.906
Dctpp1	cmpk2	ENSONIP00000026584	ENSONIP00000004602	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial.	0.900
Dctpp1	dck	ENSONIP00000026584	ENSONIP00000014035	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Deoxycytidine kinase.	0.916
Dctpp1	itpa	ENSONIP00000026584	ENSONIP00000068672	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.451
Dctpp1	nt5c2	ENSONIP00000026584	ENSONIP00000023707	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase, cytosolic IIb.	0.900
Dctpp1	nt5c3a	ENSONIP00000026584	ENSONIP00000008464	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.902
ENSONIP00000010756	I3J047_ORENI	ENSONIP00000010756	ENSONIP00000064064	Adenylosuccinate lyase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.984
ENSONIP00000010756	I3JPG0_ORENI	ENSONIP00000010756	ENSONIP00000076083	Adenylosuccinate lyase.	Adenylosuccinate lyase.	0.901