(29 nodes) Mixed, incl. Nucleoside diphosphate kinase activity, and Ribonucleoside-diphosphate reductase activity network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC100710177	Uncharacterized protein; Belongs to the adenylate kinase family. (336 aa)
	ak7	Uncharacterized protein. (690 aa)
	LOC100710041	Ribonucleotide reductase M2 b. (379 aa)
	ak2	Adenylate kinase 2; Belongs to the adenylate kinase family. (250 aa)
	LOC100705759	Adenylate kinase 7a. (697 aa)
	hddc3	HD domain containing 3. (179 aa)
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
	LOC100697135	NDK domain-containing protein; Belongs to the NDK family. (239 aa)
	ntpcr	Nucleoside-triphosphatase, cancer-related. (199 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (195 aa)
	ak5	Adenylate kinase 5; Belongs to the adenylate kinase family. (564 aa)
	I3KRC2_ORENI	Uncharacterized protein. (407 aa)
	LOC100703020	Nucleoside diphosphate kinase. (201 aa)
	nudt2	Nudix (nucleoside diphosphate linked moiety X)-type motif 2. (149 aa)
	entpd2	Ectonucleoside triphosphate diphosphohydrolase 2b; Belongs to the GDA1/CD39 NTPase family. (507 aa)
	ak6	Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (176 aa)
	LOC100709923	Uncharacterized protein. (866 aa)
	LOC100696561	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (822 aa)
	LOC100708787	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (592 aa)
	LOC100694900	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (813 aa)
	LOC100696772	NME/NM23 nucleoside diphosphate kinase 2a; Belongs to the NDK family. (152 aa)
	I3JFA0_ORENI	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (773 aa)
	nme3	Nucleoside diphosphate kinase. (244 aa)
	tpk1	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (252 aa)
	ak3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
	LOC100690751	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (590 aa)
	nme6	Nucleoside diphosphate kinase 6 isoform X1. (182 aa)
	Thtpa	Thiamine-triphosphatase isoform X1. (233 aa)
	dpt	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (402 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK1	I3JFA0_ORENI	ENSONIP00000018869	ENSONIP00000046980	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.901
AK1	I3KRC2_ORENI	ENSONIP00000018869	ENSONIP00000023667	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Uncharacterized protein.	0.751
AK1	LOC100690751	ENSONIP00000018869	ENSONIP00000062127	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.482
AK1	LOC100694900	ENSONIP00000018869	ENSONIP00000040584	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.824
AK1	LOC100696561	ENSONIP00000018869	ENSONIP00000039351	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.824
AK1	LOC100696772	ENSONIP00000018869	ENSONIP00000042960	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	NME/NM23 nucleoside diphosphate kinase 2a; Belongs to the NDK family.	0.785
AK1	LOC100697135	ENSONIP00000018869	ENSONIP00000011679	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	NDK domain-containing protein; Belongs to the NDK family.	0.785
AK1	LOC100703020	ENSONIP00000018869	ENSONIP00000024381	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Nucleoside diphosphate kinase.	0.785
AK1	LOC100705759	ENSONIP00000018869	ENSONIP00000007146	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 7a.	0.956
AK1	LOC100708787	ENSONIP00000018869	ENSONIP00000039572	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.482
AK1	LOC100709923	ENSONIP00000018869	ENSONIP00000035975	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Uncharacterized protein.	0.901
AK1	LOC100710041	ENSONIP00000018869	ENSONIP00000003330	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Ribonucleotide reductase M2 b.	0.751
AK1	LOC100710177	ENSONIP00000018869	ENSONIP00000001015	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.909
AK1	Thtpa	ENSONIP00000018869	ENSONIP00000075672	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Thiamine-triphosphatase isoform X1.	0.934
AK1	ak2	ENSONIP00000018869	ENSONIP00000006316	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 2; Belongs to the adenylate kinase family.	0.947
AK1	ak3	ENSONIP00000018869	ENSONIP00000052218	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.540
AK1	ak4	ENSONIP00000018869	ENSONIP00000011062	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.946
AK1	ak5	ENSONIP00000018869	ENSONIP00000023124	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 5; Belongs to the adenylate kinase family.	0.903
AK1	ak6	ENSONIP00000018869	ENSONIP00000035425	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily.	0.935
AK1	ak7	ENSONIP00000018869	ENSONIP00000002153	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Uncharacterized protein.	0.956