(10 nodes) E2F/DP family winged-helix DNA-binding domain, and Rb C-terminal domain network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rbl1	Retinoblastoma-like 1 (p107). (1064 aa)
	LOC100705578	E2F_TDP domain-containing protein. (79 aa)
	E2F3	E2F transcription factor 3. (444 aa)
	e2f1	E2F transcription factor 1. (454 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (396 aa)
	tfdp1	Transcription factor. (413 aa)
	LOC100692495	Retinoblastoma-like 2 (p130). (1078 aa)
	e2f2	Si:ch211-160f23.5. (448 aa)
	e2f4	E2F transcription factor 4. (407 aa)
	rb1	Retinoblastoma 1. (919 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E2F3	LOC100692495	ENSONIP00000008921	ENSONIP00000022971	E2F transcription factor 3.	Retinoblastoma-like 2 (p130).	0.981
E2F3	LOC100705578	ENSONIP00000008921	ENSONIP00000007195	E2F transcription factor 3.	E2F_TDP domain-containing protein.	0.685
E2F3	ccna1	ENSONIP00000008921	ENSONIP00000015894	E2F transcription factor 3.	Cyclin A1; Belongs to the cyclin family.	0.970
E2F3	e2f1	ENSONIP00000008921	ENSONIP00000011586	E2F transcription factor 3.	E2F transcription factor 1.	0.967
E2F3	e2f2	ENSONIP00000008921	ENSONIP00000029348	E2F transcription factor 3.	Si:ch211-160f23.5.	0.915
E2F3	e2f4	ENSONIP00000008921	ENSONIP00000038581	E2F transcription factor 3.	E2F transcription factor 4.	0.727
E2F3	rb1	ENSONIP00000008921	ENSONIP00000076566	E2F transcription factor 3.	Retinoblastoma 1.	0.988
E2F3	rbl1	ENSONIP00000008921	ENSONIP00000006602	E2F transcription factor 3.	Retinoblastoma-like 1 (p107).	0.981
E2F3	tfdp1	ENSONIP00000008921	ENSONIP00000017841	E2F transcription factor 3.	Transcription factor.	0.983
LOC100692495	E2F3	ENSONIP00000022971	ENSONIP00000008921	Retinoblastoma-like 2 (p130).	E2F transcription factor 3.	0.981
LOC100692495	LOC100705578	ENSONIP00000022971	ENSONIP00000007195	Retinoblastoma-like 2 (p130).	E2F_TDP domain-containing protein.	0.992
LOC100692495	ccna1	ENSONIP00000022971	ENSONIP00000015894	Retinoblastoma-like 2 (p130).	Cyclin A1; Belongs to the cyclin family.	0.835
LOC100692495	e2f1	ENSONIP00000022971	ENSONIP00000011586	Retinoblastoma-like 2 (p130).	E2F transcription factor 1.	0.975
LOC100692495	e2f2	ENSONIP00000022971	ENSONIP00000029348	Retinoblastoma-like 2 (p130).	Si:ch211-160f23.5.	0.989
LOC100692495	e2f4	ENSONIP00000022971	ENSONIP00000038581	Retinoblastoma-like 2 (p130).	E2F transcription factor 4.	0.992
LOC100692495	rb1	ENSONIP00000022971	ENSONIP00000076566	Retinoblastoma-like 2 (p130).	Retinoblastoma 1.	0.947
LOC100692495	rbl1	ENSONIP00000022971	ENSONIP00000006602	Retinoblastoma-like 2 (p130).	Retinoblastoma-like 1 (p107).	0.912
LOC100692495	tfdp1	ENSONIP00000022971	ENSONIP00000017841	Retinoblastoma-like 2 (p130).	Transcription factor.	0.996
LOC100705578	E2F3	ENSONIP00000007195	ENSONIP00000008921	E2F_TDP domain-containing protein.	E2F transcription factor 3.	0.685
LOC100705578	LOC100692495	ENSONIP00000007195	ENSONIP00000022971	E2F_TDP domain-containing protein.	Retinoblastoma-like 2 (p130).	0.992