(19 nodes) Mixed, incl. Sema4D induced cell migration and growth-cone collapse, and Serine/threonine-protein kinase N, first HR1 domain network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100708879	Protein kinase N1b. (956 aa)
	Rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
	LOC100708196	Uncharacterized protein. (1408 aa)
	LOC100710477	Ras homolog gene family, member Ab. (193 aa)
	I3KS58_ORENI	CDC42 binding protein kinase beta (DMPK-like); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1648 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (139 aa)
	rhoh	Ras homolog family member H. (188 aa)
	rnd3	Rho family GTPase 3a. (243 aa)
	ENSONIP00000035128	annotation not available (878 aa)
	ENSONIP00000036497	annotation not available (254 aa)
	rock2	Rho-associated, coiled-coil containing protein kinase 2a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1394 aa)
	LOC100707445	Uncharacterized protein. (193 aa)
	LOC100705424	Rho family GTPase 1b. (232 aa)
	LOC100699098	Ras homolog family member V. (281 aa)
	LOC100701417	Rho-associated, coiled-coil containing protein kinase 2b; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1515 aa)
	ENSONIP00000071248	Muscle M-line assembly protein unc-89 isoform X2. (602 aa)
	pkn2	Protein kinase N2. (1030 aa)
	cdc42bpa	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1800 aa)
	pkn1	Protein kinase N1a. (953 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000035128	LOC100699098	ENSONIP00000035128	ENSONIP00000068677	annotation not available	Ras homolog family member V.	0.697
ENSONIP00000035128	LOC100705424	ENSONIP00000035128	ENSONIP00000045815	annotation not available	Rho family GTPase 1b.	0.697
ENSONIP00000035128	LOC100707445	ENSONIP00000035128	ENSONIP00000044081	annotation not available	Uncharacterized protein.	0.697
ENSONIP00000035128	LOC100708879	ENSONIP00000035128	ENSONIP00000010211	annotation not available	Protein kinase N1b.	0.406
ENSONIP00000035128	LOC100710477	ENSONIP00000035128	ENSONIP00000023779	annotation not available	Ras homolog gene family, member Ab.	0.697
ENSONIP00000035128	RHOB	ENSONIP00000035128	ENSONIP00000025753	annotation not available	Rho-related GTP-binding protein RhoB.	0.697
ENSONIP00000035128	pkn1	ENSONIP00000035128	ENSONIP00000080361	annotation not available	Protein kinase N1a.	0.406
ENSONIP00000035128	pkn2	ENSONIP00000035128	ENSONIP00000076241	annotation not available	Protein kinase N2.	0.406
ENSONIP00000035128	rhoh	ENSONIP00000035128	ENSONIP00000026715	annotation not available	Ras homolog family member H.	0.697
ENSONIP00000035128	rnd3	ENSONIP00000035128	ENSONIP00000029756	annotation not available	Rho family GTPase 3a.	0.697
ENSONIP00000036497	LOC100699098	ENSONIP00000036497	ENSONIP00000068677	annotation not available	Ras homolog family member V.	0.697
ENSONIP00000036497	LOC100705424	ENSONIP00000036497	ENSONIP00000045815	annotation not available	Rho family GTPase 1b.	0.697
ENSONIP00000036497	LOC100707445	ENSONIP00000036497	ENSONIP00000044081	annotation not available	Uncharacterized protein.	0.697
ENSONIP00000036497	LOC100708879	ENSONIP00000036497	ENSONIP00000010211	annotation not available	Protein kinase N1b.	0.406
ENSONIP00000036497	LOC100710477	ENSONIP00000036497	ENSONIP00000023779	annotation not available	Ras homolog gene family, member Ab.	0.697
ENSONIP00000036497	RHOB	ENSONIP00000036497	ENSONIP00000025753	annotation not available	Rho-related GTP-binding protein RhoB.	0.697
ENSONIP00000036497	pkn1	ENSONIP00000036497	ENSONIP00000080361	annotation not available	Protein kinase N1a.	0.406
ENSONIP00000036497	pkn2	ENSONIP00000036497	ENSONIP00000076241	annotation not available	Protein kinase N2.	0.406
ENSONIP00000036497	rhoh	ENSONIP00000036497	ENSONIP00000026715	annotation not available	Ras homolog family member H.	0.697
ENSONIP00000036497	rnd3	ENSONIP00000036497	ENSONIP00000029756	annotation not available	Rho family GTPase 3a.	0.697