(31 nodes) RHOU GTPase cycle, and Myosin light chain kinase activity network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	iqgap3	IQ motif containing GTPase activating protein 3. (1635 aa)
	pak1	Non-specific serine/threonine protein kinase. (669 aa)
	arhgef6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (771 aa)
	nck1	Cytoplasmic protein. (392 aa)
	LOC100705444	Uncharacterized protein. (189 aa)
	LOC100705703	Uncharacterized protein. (190 aa)
	LOC100708294	Non-specific serine/threonine protein kinase. (657 aa)
	I3JMD7_ORENI	G protein-coupled receptor kinase interacting ArfGAP 1. (737 aa)
	pak6	Non-specific serine/threonine protein kinase. (698 aa)
	nck2	Cytoplasmic protein. (398 aa)
	iqgap2	IQ motif containing GTPase activating protein 2. (1662 aa)
	I3KK64_ORENI	Uncharacterized protein. (278 aa)
	LOC100696183	Non-specific serine/threonine protein kinase. (632 aa)
	LOC100704392	Rho GTPase activating protein 17. (883 aa)
	arhgef7	Rho guanine nucleotide exchange factor (GEF) 7a. (862 aa)
	LOC100689713	FYVE, RhoGEF and PH domain containing 3. (917 aa)
	pak2	Non-specific serine/threonine protein kinase. (536 aa)
	LOC100693200	Rho GTPase activating protein 17b. (900 aa)
	LOC100702039	Uncharacterized protein LOC100702039. (392 aa)
	Fgd1	FYVE, RhoGEF and PH domain containing 1. (929 aa)
	LOC100696655	Uncharacterized protein. (738 aa)
	LOC100696931	Rho guanine nucleotide exchange factor (GEF) 7b. (849 aa)
	LOC100696557	Uncharacterized protein. (191 aa)
	LOC100704574	Myosin light chain kinase family, member 4a. (830 aa)
	pak5	Non-specific serine/threonine protein kinase. (767 aa)
	LOC100712562	Uncharacterized protein. (191 aa)
	git2	G protein-coupled receptor kinase interacting ArfGAP 2a. (779 aa)
	I3JIW9_ORENI	Uncharacterized protein. (195 aa)
	mylk4	Myosin light chain kinase family, member 4b; Belongs to the protein kinase superfamily. (729 aa)
	PAK3	P21 (RAC1) activated kinase 3. (655 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fgd1	I3JIW9_ORENI	ENSONIP00000053639	ENSONIP00000070955	FYVE, RhoGEF and PH domain containing 1.	Uncharacterized protein.	0.931
Fgd1	LOC100689713	ENSONIP00000053639	ENSONIP00000035745	FYVE, RhoGEF and PH domain containing 1.	FYVE, RhoGEF and PH domain containing 3.	0.900
Fgd1	LOC100696557	ENSONIP00000053639	ENSONIP00000061896	FYVE, RhoGEF and PH domain containing 1.	Uncharacterized protein.	0.931
Fgd1	LOC100705444	ENSONIP00000053639	ENSONIP00000008814	FYVE, RhoGEF and PH domain containing 1.	Uncharacterized protein.	0.931
Fgd1	LOC100705703	ENSONIP00000053639	ENSONIP00000008815	FYVE, RhoGEF and PH domain containing 1.	Uncharacterized protein.	0.931
Fgd1	LOC100712562	ENSONIP00000053639	ENSONIP00000067416	FYVE, RhoGEF and PH domain containing 1.	Uncharacterized protein.	0.931
I3JIW9_ORENI	Fgd1	ENSONIP00000070955	ENSONIP00000053639	Uncharacterized protein.	FYVE, RhoGEF and PH domain containing 1.	0.931
I3JIW9_ORENI	I3JMD7_ORENI	ENSONIP00000070955	ENSONIP00000010032	Uncharacterized protein.	G protein-coupled receptor kinase interacting ArfGAP 1.	0.417
I3JIW9_ORENI	LOC100689713	ENSONIP00000070955	ENSONIP00000035745	Uncharacterized protein.	FYVE, RhoGEF and PH domain containing 3.	0.931
I3JIW9_ORENI	LOC100693200	ENSONIP00000070955	ENSONIP00000041880	Uncharacterized protein.	Rho GTPase activating protein 17b.	0.928
I3JIW9_ORENI	LOC100696183	ENSONIP00000070955	ENSONIP00000023718	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.852
I3JIW9_ORENI	LOC100696655	ENSONIP00000070955	ENSONIP00000055815	Uncharacterized protein.	Uncharacterized protein.	0.417
I3JIW9_ORENI	LOC100696931	ENSONIP00000070955	ENSONIP00000056826	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 7b.	0.565
I3JIW9_ORENI	LOC100702039	ENSONIP00000070955	ENSONIP00000050170	Uncharacterized protein.	Uncharacterized protein LOC100702039.	0.565
I3JIW9_ORENI	LOC100704392	ENSONIP00000070955	ENSONIP00000024902	Uncharacterized protein.	Rho GTPase activating protein 17.	0.928
I3JIW9_ORENI	LOC100708294	ENSONIP00000070955	ENSONIP00000009766	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.852
I3JIW9_ORENI	PAK2	ENSONIP00000070955	ENSONIP00000000917	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.964
I3JIW9_ORENI	PAK3	ENSONIP00000070955	ENSONIP00000077097	Uncharacterized protein.	P21 (RAC1) activated kinase 3.	0.876
I3JIW9_ORENI	arhgef6	ENSONIP00000070955	ENSONIP00000003375	Uncharacterized protein.	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.565
I3JIW9_ORENI	arhgef7	ENSONIP00000070955	ENSONIP00000032310	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 7a.	0.565