(72 nodes) Mixed, incl. Toll-like receptor signaling pathway, and NIK/NF-kappaB signaling network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100691708	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (305 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (624 aa)
	LOC100698922	MALT paracaspase 2. (826 aa)
	rel	V-rel avian reticuloendotheliosis viral oncogene homolog. (609 aa)
	relb	RHD domain-containing protein. (591 aa)
	map3k8	Mitogen-activated protein kinase kinase kinase 8. (475 aa)
	I3J7X5_ORENI	TIR domain-containing protein; Belongs to the Toll-like receptor family. (576 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (291 aa)
	LOC100702807	Uncharacterized protein. (693 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
	nfkbie	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (347 aa)
	Nfkb2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (862 aa)
	card11	Caspase recruitment domain family, member 11. (1162 aa)
	bcl10	BCL10 immune signaling adaptor. (247 aa)
	LOC100692869	Component of inhibitor of nuclear factor kappa B kinase complex. (757 aa)
	LOC100703629	Toll-like receptor 3; Belongs to the Toll-like receptor family. (912 aa)
	LOC102078975	Caspase recruitment domain family, member 9. (531 aa)
	ENSONIP00000016512	annotation not available (313 aa)
	ENSONIP00000016513	annotation not available (281 aa)
	LOC102076024	TIR domain-containing protein; Belongs to the Toll-like receptor family. (827 aa)
	LOC102077990	MALT paracaspase 3. (646 aa)
	LOC100707481	MALT paracaspase 1. (828 aa)
	LOC100698148	Protein kinase domain-containing protein. (777 aa)
	prkcd	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	LOC100702954	Interferon regulatory factor 3. (466 aa)
	TLR2	Uncharacterized protein. (787 aa)
	tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1053 aa)
	rela	V-rel avian reticuloendotheliosis viral oncogene homolog A. (616 aa)
	LOC100704346	TRAF family member-associated NF-kappa-B activator isoform X2. (355 aa)
	TLR2-2	Toll-like receptor 2 isoform X1. (786 aa)
	LOC109194541	Deoxyribonuclease-1-like protein. (366 aa)
	setd6	N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (460 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (884 aa)
	CARD10	Caspase recruitment domain-containing protein 10. (1020 aa)
	tbk1	TANK-binding kinase 1. (746 aa)
	LOC100700682	TIR domain-containing protein. (982 aa)
	LOC100711257	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (421 aa)
	sting1	Stimulator of interferon genes protein. (403 aa)
	map3k20	Uncharacterized protein. (833 aa)
	I3J9E1_ORENI	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (901 aa)
	tlr2	TIR domain-containing protein. (821 aa)
	tollip	Toll interacting protein. (275 aa)
	LOC109204746	Toll-like receptor 1. (817 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (686 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (953 aa)
	unc93b1	Unc-93 homolog B1, TLR signaling regulator. (624 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	ENSONIP00000052948	annotation not available (324 aa)
	TLR2-3	Toll-like receptor 2. (670 aa)
	I3KP91_ORENI	Mitogen-activated protein kinase kinase 7. (452 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (570 aa)
	ENSONIP00000058267	annotation not available (158 aa)
	ENSONIP00000058877	annotation not available (454 aa)
	LOC100712512	Sterile alpha motif and leucine zipper containing kinase AZK. (668 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (594 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (621 aa)
	irf7	Interferon regulatory factor 7. (461 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (463 aa)
	LOC100701239	TRIF-NTD domain-containing protein. (550 aa)
	dele1	Uncharacterized protein. (837 aa)
	ENSONIP00000067167	annotation not available (255 aa)
	TLR8-2	Toll like receptor 8. (1040 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (738 aa)
	irak1	Interleukin-1 receptor-associated kinase 1. (752 aa)
	TLR8-3	Toll-like receptor 8 isoform X1. (1054 aa)
	LOC100705953	Toll-like receptor 18. (889 aa)
	LOC100693847	Deoxyribonuclease 1 like 4, tandem duplicate 1. (345 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (510 aa)
	LOC109194281	Deoxyribonuclease; Belongs to the DNase I family. (352 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD10	LOC100698922	ENSONIP00000037742	ENSONIP00000002891	Caspase recruitment domain-containing protein 10.	MALT paracaspase 2.	0.509
CARD10	LOC100707481	ENSONIP00000037742	ENSONIP00000021344	Caspase recruitment domain-containing protein 10.	MALT paracaspase 1.	0.509
CARD10	LOC102077990	ENSONIP00000037742	ENSONIP00000019138	Caspase recruitment domain-containing protein 10.	MALT paracaspase 3.	0.509
CARD10	bcl10	ENSONIP00000037742	ENSONIP00000011727	Caspase recruitment domain-containing protein 10.	BCL10 immune signaling adaptor.	0.821
ENSONIP00000016512	ENSONIP00000067167	ENSONIP00000016512	ENSONIP00000067167	annotation not available	annotation not available	0.610
ENSONIP00000016512	LOC100692869	ENSONIP00000016512	ENSONIP00000012096	annotation not available	Component of inhibitor of nuclear factor kappa B kinase complex.	0.663
ENSONIP00000016512	LOC100698148	ENSONIP00000016512	ENSONIP00000022863	annotation not available	Protein kinase domain-containing protein.	0.625
ENSONIP00000016512	ikbkb	ENSONIP00000016512	ENSONIP00000051922	annotation not available	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.663
ENSONIP00000016512	map3k8	ENSONIP00000016512	ENSONIP00000004710	annotation not available	Mitogen-activated protein kinase kinase kinase 8.	0.551
ENSONIP00000016512	myd88	ENSONIP00000016512	ENSONIP00000007350	annotation not available	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.476
ENSONIP00000016512	rel	ENSONIP00000016512	ENSONIP00000003736	annotation not available	V-rel avian reticuloendotheliosis viral oncogene homolog.	0.610
ENSONIP00000016512	rela	ENSONIP00000016512	ENSONIP00000028680	annotation not available	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.610
ENSONIP00000016512	relb	ENSONIP00000016512	ENSONIP00000004623	annotation not available	RHD domain-containing protein.	0.610
ENSONIP00000016513	ENSONIP00000067167	ENSONIP00000016513	ENSONIP00000067167	annotation not available	annotation not available	0.610
ENSONIP00000016513	LOC100692869	ENSONIP00000016513	ENSONIP00000012096	annotation not available	Component of inhibitor of nuclear factor kappa B kinase complex.	0.663
ENSONIP00000016513	LOC100698148	ENSONIP00000016513	ENSONIP00000022863	annotation not available	Protein kinase domain-containing protein.	0.625
ENSONIP00000016513	ikbkb	ENSONIP00000016513	ENSONIP00000051922	annotation not available	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.663
ENSONIP00000016513	map3k8	ENSONIP00000016513	ENSONIP00000004710	annotation not available	Mitogen-activated protein kinase kinase kinase 8.	0.551
ENSONIP00000016513	myd88	ENSONIP00000016513	ENSONIP00000007350	annotation not available	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.476
ENSONIP00000016513	rel	ENSONIP00000016513	ENSONIP00000003736	annotation not available	V-rel avian reticuloendotheliosis viral oncogene homolog.	0.610