(51 nodes) Clathrin-coated pit, and ENTH domain network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSONIP00000000682	Intersectin 2a. (1301 aa)
	LOC100690812	Epsin 3a. (615 aa)
	reps2	RALBP1 associated Eps domain containing 2. (668 aa)
	LOC100694501	AP2 associated kinase 1b. (1086 aa)
	EHD2	EH-domain containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa)
	LOC102076498	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (544 aa)
	reps1	RALBP1 associated Eps domain containing 1. (817 aa)
	eps15l1	Epidermal growth factor receptor pathway substrate 15-like 1a. (932 aa)
	I3JUL2_ORENI	SH3-domain GRB2-like (endophilin) interacting protein 1a. (757 aa)
	LOC100695123	F-BAR domain only protein 1 isoform X1. (1220 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
	LOC100703642	AP2 associated kinase 1a. (1125 aa)
	LOC100701843	Huntingtin interacting protein 1 related b. (1074 aa)
	LOC100690950	Uncharacterized protein. (1283 aa)
	epn2	Epsin 2. (576 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (230 aa)
	LOC100695148	Epsin 3b. (597 aa)
	LOC100707472	AP complex subunit beta. (953 aa)
	gak	Cyclin G associated kinase. (1327 aa)
	I3JDW8_ORENI	ArfGAP with FG repeats 1a. (613 aa)
	I3KQM1_ORENI	SH3-domain GRB2-like (endophilin) interacting protein 1b. (217 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (224 aa)
	LOC100694873	Epidermal growth factor receptor pathway substrate 15 like 1. (892 aa)
	necap2	NECAP endocytosis associated 2. (255 aa)
	hip1	Huntingtin interacting protein 1. (1050 aa)
	LOC100712537	ENTH domain-containing protein. (646 aa)
	I3KKD0_ORENI	Intersectin 2b. (1607 aa)
	LOC100694167	Epsin 1. (650 aa)
	ap1b1	AP complex subunit beta. (1001 aa)
	I3IW40_ORENI	Synaptosome associated protein 91b. (556 aa)
	Clhc1	Clathrin heavy chain linker domain-containing protein 1 isoform X1. (403 aa)
	LOC102077612	Uncharacterized protein LOC102077612 isoform X1. (991 aa)
	ENSONIP00000051001	annotation not available (240 aa)
	Snap91	Synaptosome associated protein 91a. (466 aa)
	itsn1	Intersectin 1 (SH3 domain protein). (1795 aa)
	LOC100708800	ENTH domain-containing protein. (576 aa)
	Tgoln2	Trans-Golgi network integral membrane protein 2. (336 aa)
	LOC100691387	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1642 aa)
	LOC100700052	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (965 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)
	ENSONIP00000063297	Bridging integrator 1b. (531 aa)
	LOC100708054	Epidermal growth factor receptor substrate 15 isoform X2. (1103 aa)
	LOC100696314	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (994 aa)
	fcho2	F-BAR domain only protein 2 isoform X1. (1090 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
	ralbp1	RalA binding protein 1. (660 aa)
	LOC100710793	Epsin-1 isoform X1. (892 aa)
	ap4b1	AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (843 aa)
	LOC100711908	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1705 aa)
	dnajc6	DnaJ (Hsp40) homolog, subfamily C, member 6. (972 aa)
	LOC109194194	Si:ch211-200p22.4. (630 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Clhc1	ENSONIP00000000682	ENSONIP00000044814	ENSONIP00000000682	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Intersectin 2a.	0.983
Clhc1	ENSONIP00000051001	ENSONIP00000044814	ENSONIP00000051001	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	annotation not available	0.601
Clhc1	ENSONIP00000063297	ENSONIP00000044814	ENSONIP00000063297	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Bridging integrator 1b.	0.498
Clhc1	I3IW40_ORENI	ENSONIP00000044814	ENSONIP00000044165	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Synaptosome associated protein 91b.	0.601
Clhc1	I3JUL2_ORENI	ENSONIP00000044814	ENSONIP00000012558	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	SH3-domain GRB2-like (endophilin) interacting protein 1a.	0.498
Clhc1	I3KKD0_ORENI	ENSONIP00000044814	ENSONIP00000040531	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Intersectin 2b.	0.983
Clhc1	I3KQM1_ORENI	ENSONIP00000044814	ENSONIP00000030687	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	SH3-domain GRB2-like (endophilin) interacting protein 1b.	0.498
Clhc1	LOC100690812	ENSONIP00000044814	ENSONIP00000002521	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epsin 3a.	0.753
Clhc1	LOC100690950	ENSONIP00000044814	ENSONIP00000019283	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Uncharacterized protein.	0.763
Clhc1	LOC100694167	ENSONIP00000044814	ENSONIP00000041852	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epsin 1.	0.753
Clhc1	LOC100694501	ENSONIP00000044814	ENSONIP00000004392	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP2 associated kinase 1b.	0.524
Clhc1	LOC100694873	ENSONIP00000044814	ENSONIP00000038666	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.612
Clhc1	LOC100695123	ENSONIP00000044814	ENSONIP00000012621	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	F-BAR domain only protein 1 isoform X1.	0.498
Clhc1	LOC100695148	ENSONIP00000044814	ENSONIP00000020743	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epsin 3b.	0.753
Clhc1	LOC100700052	ENSONIP00000044814	ENSONIP00000061455	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.822
Clhc1	LOC100701843	ENSONIP00000044814	ENSONIP00000016709	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Huntingtin interacting protein 1 related b.	0.763
Clhc1	LOC100703642	ENSONIP00000044814	ENSONIP00000014692	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP2 associated kinase 1a.	0.524
Clhc1	LOC100707472	ENSONIP00000044814	ENSONIP00000021924	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP complex subunit beta.	0.802
Clhc1	LOC100708054	ENSONIP00000044814	ENSONIP00000067563	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epidermal growth factor receptor substrate 15 isoform X2.	0.612
Clhc1	LOC100708800	ENSONIP00000044814	ENSONIP00000055506	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	ENTH domain-containing protein.	0.601