(16 nodes) Clathrin coat of coated pit, and Clathrin-dependent synaptic vesicle endocytosis network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSONIP00000000682	Intersectin 2a. (1301 aa)
	eps15l1	Epidermal growth factor receptor pathway substrate 15-like 1a. (932 aa)
	LOC100695123	F-BAR domain only protein 1 isoform X1. (1220 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
	epn2	Epsin 2. (576 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (230 aa)
	LOC100695148	Epsin 3b. (597 aa)
	necap2	NECAP endocytosis associated 2. (255 aa)
	I3KKD0_ORENI	Intersectin 2b. (1607 aa)
	ap1b1	AP complex subunit beta. (1001 aa)
	Clhc1	Clathrin heavy chain linker domain-containing protein 1 isoform X1. (403 aa)
	itsn1	Intersectin 1 (SH3 domain protein). (1795 aa)
	LOC100700052	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (965 aa)
	LOC100708054	Epidermal growth factor receptor substrate 15 isoform X2. (1103 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
	ap4b1	AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (843 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Clhc1	ENSONIP00000000682	ENSONIP00000044814	ENSONIP00000000682	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Intersectin 2a.	0.983
Clhc1	I3KKD0_ORENI	ENSONIP00000044814	ENSONIP00000040531	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Intersectin 2b.	0.983
Clhc1	LOC100695123	ENSONIP00000044814	ENSONIP00000012621	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	F-BAR domain only protein 1 isoform X1.	0.498
Clhc1	LOC100695148	ENSONIP00000044814	ENSONIP00000020743	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epsin 3b.	0.753
Clhc1	LOC100700052	ENSONIP00000044814	ENSONIP00000061455	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.822
Clhc1	LOC100708054	ENSONIP00000044814	ENSONIP00000067563	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epidermal growth factor receptor substrate 15 isoform X2.	0.612
Clhc1	ap1b1	ENSONIP00000044814	ENSONIP00000042829	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP complex subunit beta.	0.802
Clhc1	ap2m1	ENSONIP00000044814	ENSONIP00000013073	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.786
Clhc1	ap2s1	ENSONIP00000044814	ENSONIP00000070101	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.755
Clhc1	ap4b1	ENSONIP00000044814	ENSONIP00000073573	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	AP complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.802
Clhc1	clta	ENSONIP00000044814	ENSONIP00000020435	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.851
Clhc1	epn2	ENSONIP00000044814	ENSONIP00000019835	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epsin 2.	0.753
Clhc1	eps15l1	ENSONIP00000044814	ENSONIP00000009673	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Epidermal growth factor receptor pathway substrate 15-like 1a.	0.612
Clhc1	itsn1	ENSONIP00000044814	ENSONIP00000053712	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	Intersectin 1 (SH3 domain protein).	0.855
Clhc1	necap2	ENSONIP00000044814	ENSONIP00000039008	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	NECAP endocytosis associated 2.	0.579
ENSONIP00000000682	Clhc1	ENSONIP00000000682	ENSONIP00000044814	Intersectin 2a.	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	0.983
ENSONIP00000000682	I3KKD0_ORENI	ENSONIP00000000682	ENSONIP00000040531	Intersectin 2a.	Intersectin 2b.	0.956
ENSONIP00000000682	LOC100695123	ENSONIP00000000682	ENSONIP00000012621	Intersectin 2a.	F-BAR domain only protein 1 isoform X1.	0.986
ENSONIP00000000682	LOC100695148	ENSONIP00000000682	ENSONIP00000020743	Intersectin 2a.	Epsin 3b.	0.976
ENSONIP00000000682	LOC100700052	ENSONIP00000000682	ENSONIP00000061455	Intersectin 2a.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.981