(19 nodes) Mixed, incl. Rap/ran-GAP, and Ral protein signal transduction network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	REM1	RRAD and GEM like GTPase 1. (308 aa)
	I3J0X1_ORENI	Rap guanine nucleotide exchange factor (GEF) 5a. (869 aa)
	Sipa1l3	LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 3. (730 aa)
	ENSONIP00000006724	Signal-induced proliferation-associated 1. (1039 aa)
	gem	GTP binding protein overexpressed in skeletal muscle. (307 aa)
	I3JN12_ORENI	Ral GTPase activating protein, alpha subunit 2 (catalytic). (1939 aa)
	I3K502_ORENI	Si:ch1073-90m23.1. (641 aa)
	I3KC60_ORENI	Nucleolar protein 4-like b. (637 aa)
	RAPGEF5	Uncharacterized protein. (590 aa)
	I3JS81_ORENI	Ral GTPase activating protein, beta subunit (non-catalytic). (1498 aa)
	nkiras1	NFKB inhibitor interacting Ras-like 1. (192 aa)
	LOC100694930	RAP2A, member of RAS oncogene family b. (183 aa)
	I3J6Z9_ORENI	Signal-induced proliferation-associated 1 like 3. (785 aa)
	Rapgefl1	Rap guanine nucleotide exchange factor (GEF)-like 1. (530 aa)
	nkiras2	NFKB inhibitor interacting Ras-like 2. (192 aa)
	ENSONIP00000050813	annotation not available (1062 aa)
	LOC106097937	Glycine N-acyltransferase-like protein 3. (278 aa)
	LOC100695857	Thymocyte selection-associated high mobility group box. (524 aa)
	I3KTU9_ORENI	Ral GTPase activating protein, alpha subunit 1 (catalytic). (2446 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000006724	I3JS81_ORENI	ENSONIP00000006724	ENSONIP00000032048	Signal-induced proliferation-associated 1.	Ral GTPase activating protein, beta subunit (non-catalytic).	0.432
ENSONIP00000006724	LOC100694930	ENSONIP00000006724	ENSONIP00000041470	Signal-induced proliferation-associated 1.	RAP2A, member of RAS oncogene family b.	0.457
ENSONIP00000006724	Rapgefl1	ENSONIP00000006724	ENSONIP00000047234	Signal-induced proliferation-associated 1.	Rap guanine nucleotide exchange factor (GEF)-like 1.	0.535
ENSONIP00000050813	I3JS81_ORENI	ENSONIP00000050813	ENSONIP00000032048	annotation not available	Ral GTPase activating protein, beta subunit (non-catalytic).	0.432
ENSONIP00000050813	Sipa1l3	ENSONIP00000050813	ENSONIP00000004639	annotation not available	LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 3.	0.883
I3J0X1_ORENI	Rapgefl1	ENSONIP00000002511	ENSONIP00000047234	Rap guanine nucleotide exchange factor (GEF) 5a.	Rap guanine nucleotide exchange factor (GEF)-like 1.	0.512
I3J6Z9_ORENI	I3JS81_ORENI	ENSONIP00000042911	ENSONIP00000032048	Signal-induced proliferation-associated 1 like 3.	Ral GTPase activating protein, beta subunit (non-catalytic).	0.432
I3J6Z9_ORENI	Sipa1l3	ENSONIP00000042911	ENSONIP00000004639	Signal-induced proliferation-associated 1 like 3.	LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 3.	0.899
I3JN12_ORENI	I3JS81_ORENI	ENSONIP00000010256	ENSONIP00000032048	Ral GTPase activating protein, alpha subunit 2 (catalytic).	Ral GTPase activating protein, beta subunit (non-catalytic).	0.799
I3JN12_ORENI	nkiras1	ENSONIP00000010256	ENSONIP00000032778	Ral GTPase activating protein, alpha subunit 2 (catalytic).	NFKB inhibitor interacting Ras-like 1.	0.423
I3JN12_ORENI	nkiras2	ENSONIP00000010256	ENSONIP00000049743	Ral GTPase activating protein, alpha subunit 2 (catalytic).	NFKB inhibitor interacting Ras-like 2.	0.423
I3JS81_ORENI	ENSONIP00000006724	ENSONIP00000032048	ENSONIP00000006724	Ral GTPase activating protein, beta subunit (non-catalytic).	Signal-induced proliferation-associated 1.	0.432
I3JS81_ORENI	ENSONIP00000050813	ENSONIP00000032048	ENSONIP00000050813	Ral GTPase activating protein, beta subunit (non-catalytic).	annotation not available	0.432
I3JS81_ORENI	I3J6Z9_ORENI	ENSONIP00000032048	ENSONIP00000042911	Ral GTPase activating protein, beta subunit (non-catalytic).	Signal-induced proliferation-associated 1 like 3.	0.432
I3JS81_ORENI	I3JN12_ORENI	ENSONIP00000032048	ENSONIP00000010256	Ral GTPase activating protein, beta subunit (non-catalytic).	Ral GTPase activating protein, alpha subunit 2 (catalytic).	0.799
I3JS81_ORENI	I3K502_ORENI	ENSONIP00000032048	ENSONIP00000016197	Ral GTPase activating protein, beta subunit (non-catalytic).	Si:ch1073-90m23.1.	0.432
I3JS81_ORENI	I3KC60_ORENI	ENSONIP00000032048	ENSONIP00000018705	Ral GTPase activating protein, beta subunit (non-catalytic).	Nucleolar protein 4-like b.	0.432
I3JS81_ORENI	I3KTU9_ORENI	ENSONIP00000032048	ENSONIP00000076316	Ral GTPase activating protein, beta subunit (non-catalytic).	Ral GTPase activating protein, alpha subunit 1 (catalytic).	0.799
I3JS81_ORENI	LOC106097937	ENSONIP00000032048	ENSONIP00000052483	Ral GTPase activating protein, beta subunit (non-catalytic).	Glycine N-acyltransferase-like protein 3.	0.531
I3JS81_ORENI	Sipa1l3	ENSONIP00000032048	ENSONIP00000004639	Ral GTPase activating protein, beta subunit (non-catalytic).	LOW QUALITY PROTEIN: signal-induced proliferation-associated 1-like protein 3.	0.432