(53 nodes) Mixed, incl. Ubiquitin specific protease, conserved site, and Positive regulation of protein deubiquitination network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	usp45	Ubiquitin carboxyl-terminal hydrolase. (823 aa)
	usp50	Ubiquitin carboxyl-terminal hydrolase. (769 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (931 aa)
	I3IUU1_ORENI	Ring finger protein 123. (1279 aa)
	usp40	Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1290 aa)
	usp19	Ubiquitin specific peptidase 19. (1517 aa)
	LOC100703527	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (363 aa)
	wdr20	WD repeat domain 20a. (614 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1440 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1383 aa)
	I3JGL4_ORENI	PPM-type phosphatase domain-containing protein. (1617 aa)
	I3K8V7_ORENI	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (304 aa)
	usp48	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1050 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (830 aa)
	I3JTC4_ORENI	PH domain and leucine rich repeat protein phosphatase 1. (1576 aa)
	Lrrc1	Leucine rich repeat containing 1. (590 aa)
	usp38	Ubiquitin specific peptidase 38; Belongs to the peptidase C19 family. (1034 aa)
	I3JX38_ORENI	UBA domain containing 1. (405 aa)
	uvssa	UV-stimulated scaffold protein A. (773 aa)
	usp5	Ubiquitin carboxyl-terminal hydrolase. (848 aa)
	Sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (997 aa)
	Otud5	OTU deubiquitinase 5a. (537 aa)
	wdr48	WD repeat domain 48b. (690 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1115 aa)
	usp25	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1144 aa)
	LOC100711529	Growth arrest specific 7. (474 aa)
	LOC100692994	Polyubiquitin. (92 aa)
	usp28	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1231 aa)
	LOC100706784	Ubiquitin carboxyl-terminal hydrolase. (394 aa)
	I3JCU4_ORENI	Ubiquitin carboxyl-terminal hydrolase. (1008 aa)
	LOC100702008	Transmembrane phosphatase with tensin homology. (516 aa)
	usp12	Ubiquitin specific peptidase 12a; Belongs to the peptidase C19 family. (374 aa)
	wwp2	E3 ubiquitin-protein ligase. (908 aa)
	USP15	Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (946 aa)
	ENSONIP00000043569	annotation not available (83 aa)
	usp4	Ubiquitin carboxyl-terminal hydrolase. (999 aa)
	LOC100702516	WD repeat domain 20b. (632 aa)
	LOC100690273	Ubiquitin carboxyl-terminal hydrolase 43. (1222 aa)
	CUL7	Cullin 7; Belongs to the cullin family. (2649 aa)
	rnf41	Ring finger protein 41. (318 aa)
	otud6b	OTU domain containing 6B. (315 aa)
	usp20	Ubiquitin carboxyl-terminal hydrolase. (943 aa)
	ENSONIP00000062498	LOW QUALITY PROTEIN: WD repeat-containing protein 20. (180 aa)
	LOC100695864	Ubiquitin carboxyl-terminal hydrolase. (439 aa)
	usp46	Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (370 aa)
	ENSONIP00000066937	annotation not available (154 aa)
	I3KBS9_ORENI	Ubiquitin carboxyl-terminal hydrolase. (1003 aa)
	uchl1	Ubiquitin carboxyl-terminal hydrolase. (220 aa)
	usp13	Ubiquitinyl hydrolase 1. (879 aa)
	ENSONIP00000075022	Glutathione synthetase-like. (151 aa)
	LOC100707592	Inositol polyphosphate-4-phosphatase type I Ab. (1025 aa)
	LOC100708948	USP domain-containing protein; Belongs to the peptidase C19 family. (602 aa)
	ENSONIP00000080005	annotation not available (211 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL7	Sart3	ENSONIP00000050071	ENSONIP00000016863	Cullin 7; Belongs to the cullin family.	Spliceosome associated factor 3, U4/U6 recycling protein.	0.742
CUL7	usp4	ENSONIP00000050071	ENSONIP00000044089	Cullin 7; Belongs to the cullin family.	Ubiquitin carboxyl-terminal hydrolase.	0.644
CUL7	wwp2	ENSONIP00000050071	ENSONIP00000041467	Cullin 7; Belongs to the cullin family.	E3 ubiquitin-protein ligase.	0.743
ENSONIP00000043569	ENSONIP00000080005	ENSONIP00000043569	ENSONIP00000080005	annotation not available	annotation not available	0.560
ENSONIP00000043569	LOC100706784	ENSONIP00000043569	ENSONIP00000032110	annotation not available	Ubiquitin carboxyl-terminal hydrolase.	0.451
ENSONIP00000043569	LOC100711529	ENSONIP00000043569	ENSONIP00000024623	annotation not available	Growth arrest specific 7.	0.701
ENSONIP00000043569	Otud5	ENSONIP00000043569	ENSONIP00000018378	annotation not available	OTU deubiquitinase 5a.	0.434
ENSONIP00000043569	rnf41	ENSONIP00000043569	ENSONIP00000052504	annotation not available	Ring finger protein 41.	0.439
ENSONIP00000043569	uchl1	ENSONIP00000043569	ENSONIP00000072796	annotation not available	Ubiquitin carboxyl-terminal hydrolase.	0.592
ENSONIP00000043569	usp1	ENSONIP00000043569	ENSONIP00000011109	annotation not available	Ubiquitin carboxyl-terminal hydrolase.	0.451
ENSONIP00000043569	usp12	ENSONIP00000043569	ENSONIP00000040525	annotation not available	Ubiquitin specific peptidase 12a; Belongs to the peptidase C19 family.	0.451
ENSONIP00000043569	usp13	ENSONIP00000043569	ENSONIP00000074790	annotation not available	Ubiquitinyl hydrolase 1.	0.734
ENSONIP00000043569	usp25	ENSONIP00000043569	ENSONIP00000019966	annotation not available	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family.	0.534
ENSONIP00000043569	usp28	ENSONIP00000043569	ENSONIP00000030626	annotation not available	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family.	0.534
ENSONIP00000043569	usp38	ENSONIP00000043569	ENSONIP00000012563	annotation not available	Ubiquitin specific peptidase 38; Belongs to the peptidase C19 family.	0.451
ENSONIP00000043569	usp40	ENSONIP00000043569	ENSONIP00000001667	annotation not available	Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family.	0.534
ENSONIP00000043569	usp46	ENSONIP00000043569	ENSONIP00000064639	annotation not available	Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family.	0.451
ENSONIP00000043569	usp48	ENSONIP00000043569	ENSONIP00000010944	annotation not available	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family.	0.534
ENSONIP00000043569	usp5	ENSONIP00000043569	ENSONIP00000016364	annotation not available	Ubiquitin carboxyl-terminal hydrolase.	0.734
ENSONIP00000043569	usp7	ENSONIP00000043569	ENSONIP00000019747	annotation not available	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.534