(59 nodes) Mixed, incl. Papain family cysteine protease, and Aspartic-type peptidase activity network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ctso	Cathepsin O; Belongs to the peptidase C1 family. (368 aa)
	I3J3L2_ORENI	Uncharacterized protein; Belongs to the peptidase C1 family. (351 aa)
	LOC100711989	Cathepsin 12; Belongs to the peptidase C1 family. (352 aa)
	LOC100705720	Cathepsin L.1; Belongs to the peptidase C1 family. (339 aa)
	ENSONIP00000004354	annotation not available (342 aa)
	LOC102080531	Saposin B-type domain-containing protein. (140 aa)
	LOC112841639	NK-lysin tandem duplicate 3. (161 aa)
	LOC100704278	Uncharacterized protein; Belongs to the peptidase C1 family. (346 aa)
	ctsc	Cathepsin C; Belongs to the peptidase C1 family. (457 aa)
	LOC100700357	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (397 aa)
	psap	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (541 aa)
	LOC100691504	Renin; Belongs to the peptidase A1 family. (396 aa)
	LOC100695799	SERPIN domain-containing protein; Belongs to the serpin family. (417 aa)
	grn	Granulin b. (827 aa)
	mmp19	Matrix metallopeptidase 19. (477 aa)
	lgmn	Legumain. (452 aa)
	I3KUE2_ORENI	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (351 aa)
	LOC100705280	Zgc:103438; Belongs to the peptidase C1 family. (551 aa)
	LOC100690911	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family. (395 aa)
	ENSONIP00000028437	annotation not available (139 aa)
	LOC102080439	Uncharacterized LOC102080439. (173 aa)
	LOC100692931	GRANULINS domain-containing protein. (211 aa)
	LOC100702144	Uncharacterized protein; Belongs to the peptidase C1 family. (330 aa)
	LOC100695263	LOW QUALITY PROTEIN: pepsin A. (361 aa)
	LOC100700247	Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (689 aa)
	I3K9F7_ORENI	Uncharacterized protein; Belongs to the peptidase C1 family. (393 aa)
	LOC100712479	SERPIN domain-containing protein; Belongs to the serpin family. (449 aa)
	LOC100704815	Uncharacterized protein; Belongs to the peptidase C1 family. (347 aa)
	LOC100711179	Si:busm1-57f23.1. (145 aa)
	LOC100700379	Nothepsin; Belongs to the peptidase A1 family. (406 aa)
	LOC100704001	Surfactant protein Bb. (100 aa)
	tmem130	Transmembrane protein 130. (314 aa)
	LOC100691072	Peptidoglycan-recognition protein SC2. (167 aa)
	pepsin	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (377 aa)
	I3KQ51_ORENI	Cystatin domain-containing protein. (141 aa)
	ENSONIP00000049419	annotation not available (138 aa)
	I3K7M6_ORENI	Uncharacterized protein. (129 aa)
	csta	Cystatin A; Belongs to the cystatin family. (101 aa)
	ENSONIP00000053083	Protocadherin b. (656 aa)
	SLC25A12	Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (696 aa)
	LOC100693478	Progranulin. (210 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	ENSONIP00000057007	Cystatin isoform X1. (109 aa)
	granulin	Progranulin. (206 aa)
	LOC100703974	Cathepsin L1-like protein; Belongs to the peptidase C1 family. (354 aa)
	ctsd	Cathepsin D; Belongs to the peptidase A1 family. (400 aa)
	chid1	Chitinase domain containing 1; Belongs to the glycosyl hydrolase 18 family. (389 aa)
	LOC100705087	Uncharacterized protein; Belongs to the peptidase C1 family. (342 aa)
	ENSONIP00000067100	annotation not available (105 aa)
	ENSONIP00000067903	annotation not available (136 aa)
	LOC100707183	G protein-coupled receptor 37 like 1b. (519 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (324 aa)
	LOC100695758	Cathepsin S; Belongs to the peptidase C1 family. (337 aa)
	I3K7M7_ORENI	Uncharacterized protein. (154 aa)
	ENSONIP00000074992	Cathepsin L1. (249 aa)
	ENSONIP00000075149	annotation not available (139 aa)
	ENSONIP00000075575	annotation not available (139 aa)
	LOC112841614	Uncharacterized protein. (207 aa)
	LOC100705351	Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000004354	ctso	ENSONIP00000004354	ENSONIP00000001451	annotation not available	Cathepsin O; Belongs to the peptidase C1 family.	0.456
ENSONIP00000004354	lgmn	ENSONIP00000004354	ENSONIP00000024678	annotation not available	Legumain.	0.418
ENSONIP00000049419	ctso	ENSONIP00000049419	ENSONIP00000001451	annotation not available	Cathepsin O; Belongs to the peptidase C1 family.	0.445
ENSONIP00000053083	grn	ENSONIP00000053083	ENSONIP00000022826	Protocadherin b.	Granulin b.	0.480
ENSONIP00000057007	csta	ENSONIP00000057007	ENSONIP00000051670	Cystatin isoform X1.	Cystatin A; Belongs to the cystatin family.	0.542
ENSONIP00000057007	lgmn	ENSONIP00000057007	ENSONIP00000024678	Cystatin isoform X1.	Legumain.	0.484
ENSONIP00000067100	ctsc	ENSONIP00000067100	ENSONIP00000006441	annotation not available	Cathepsin C; Belongs to the peptidase C1 family.	0.422
ENSONIP00000067100	ctso	ENSONIP00000067100	ENSONIP00000001451	annotation not available	Cathepsin O; Belongs to the peptidase C1 family.	0.445
ENSONIP00000067100	ctsz	ENSONIP00000067100	ENSONIP00000056620	annotation not available	Cathepsin Z; Belongs to the peptidase C1 family.	0.422
ENSONIP00000067903	LOC100702144	ENSONIP00000067903	ENSONIP00000031986	annotation not available	Uncharacterized protein; Belongs to the peptidase C1 family.	0.503
ENSONIP00000067903	ctsc	ENSONIP00000067903	ENSONIP00000006441	annotation not available	Cathepsin C; Belongs to the peptidase C1 family.	0.490
ENSONIP00000067903	ctsh	ENSONIP00000067903	ENSONIP00000070506	annotation not available	Cathepsin H; Belongs to the peptidase C1 family.	0.503
ENSONIP00000067903	ctso	ENSONIP00000067903	ENSONIP00000001451	annotation not available	Cathepsin O; Belongs to the peptidase C1 family.	0.445
ENSONIP00000067903	ctsz	ENSONIP00000067903	ENSONIP00000056620	annotation not available	Cathepsin Z; Belongs to the peptidase C1 family.	0.446
ENSONIP00000074992	LOC100700357	ENSONIP00000074992	ENSONIP00000010740	Cathepsin L1.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.653
ENSONIP00000074992	ctsd	ENSONIP00000074992	ENSONIP00000059874	Cathepsin L1.	Cathepsin D; Belongs to the peptidase A1 family.	0.652
ENSONIP00000074992	ctso	ENSONIP00000074992	ENSONIP00000001451	Cathepsin L1.	Cathepsin O; Belongs to the peptidase C1 family.	0.426
ENSONIP00000074992	lgmn	ENSONIP00000074992	ENSONIP00000024678	Cathepsin L1.	Legumain.	0.524
I3J3L2_ORENI	LOC100692931	ENSONIP00000003452	ENSONIP00000031681	Uncharacterized protein; Belongs to the peptidase C1 family.	GRANULINS domain-containing protein.	0.439
I3J3L2_ORENI	LOC100693478	ENSONIP00000003452	ENSONIP00000054312	Uncharacterized protein; Belongs to the peptidase C1 family.	Progranulin.	0.439