(18 nodes) Cysteine peptidase, asparagine active site, and Aspartyl protease network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I3J3L2_ORENI	Uncharacterized protein; Belongs to the peptidase C1 family. (351 aa)
	LOC100705720	Cathepsin L.1; Belongs to the peptidase C1 family. (339 aa)
	ctsc	Cathepsin C; Belongs to the peptidase C1 family. (457 aa)
	LOC100700357	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (397 aa)
	LOC100691504	Renin; Belongs to the peptidase A1 family. (396 aa)
	lgmn	Legumain. (452 aa)
	I3KUE2_ORENI	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (351 aa)
	LOC100690911	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family. (395 aa)
	LOC100692931	GRANULINS domain-containing protein. (211 aa)
	LOC100702144	Uncharacterized protein; Belongs to the peptidase C1 family. (330 aa)
	LOC100704815	Uncharacterized protein; Belongs to the peptidase C1 family. (347 aa)
	LOC100700379	Nothepsin; Belongs to the peptidase A1 family. (406 aa)
	LOC100693478	Progranulin. (210 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	ctsd	Cathepsin D; Belongs to the peptidase A1 family. (400 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (324 aa)
	LOC100695758	Cathepsin S; Belongs to the peptidase C1 family. (337 aa)
	LOC100705351	Uncharacterized protein; Belongs to the peptidase C1 family. (334 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3J3L2_ORENI	LOC100692931	ENSONIP00000003452	ENSONIP00000031681	Uncharacterized protein; Belongs to the peptidase C1 family.	GRANULINS domain-containing protein.	0.439
I3J3L2_ORENI	LOC100693478	ENSONIP00000003452	ENSONIP00000054312	Uncharacterized protein; Belongs to the peptidase C1 family.	Progranulin.	0.439
I3J3L2_ORENI	LOC100700357	ENSONIP00000003452	ENSONIP00000010740	Uncharacterized protein; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.599
I3J3L2_ORENI	ctsc	ENSONIP00000003452	ENSONIP00000006441	Uncharacterized protein; Belongs to the peptidase C1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.424
I3J3L2_ORENI	ctsd	ENSONIP00000003452	ENSONIP00000059874	Uncharacterized protein; Belongs to the peptidase C1 family.	Cathepsin D; Belongs to the peptidase A1 family.	0.645
I3J3L2_ORENI	lgmn	ENSONIP00000003452	ENSONIP00000024678	Uncharacterized protein; Belongs to the peptidase C1 family.	Legumain.	0.549
I3KUE2_ORENI	LOC100702144	ENSONIP00000024738	ENSONIP00000031986	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.503
I3KUE2_ORENI	ctsc	ENSONIP00000024738	ENSONIP00000006441	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.490
I3KUE2_ORENI	ctsh	ENSONIP00000024738	ENSONIP00000070506	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.503
I3KUE2_ORENI	ctsz	ENSONIP00000024738	ENSONIP00000056620	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.446
LOC100690911	LOC100692931	ENSONIP00000027949	ENSONIP00000031681	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	GRANULINS domain-containing protein.	0.432
LOC100690911	LOC100693478	ENSONIP00000027949	ENSONIP00000054312	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Progranulin.	0.432
LOC100690911	LOC100700357	ENSONIP00000027949	ENSONIP00000010740	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.688
LOC100690911	LOC100700379	ENSONIP00000027949	ENSONIP00000044199	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Nothepsin; Belongs to the peptidase A1 family.	0.451
LOC100690911	ctsc	ENSONIP00000027949	ENSONIP00000006441	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.421
LOC100690911	ctsd	ENSONIP00000027949	ENSONIP00000059874	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Cathepsin D; Belongs to the peptidase A1 family.	0.693
LOC100690911	ctsz	ENSONIP00000027949	ENSONIP00000056620	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.414
LOC100690911	lgmn	ENSONIP00000027949	ENSONIP00000024678	Cathepsin S, ortholog 1; Belongs to the peptidase C1 family.	Legumain.	0.537
LOC100691504	LOC100702144	ENSONIP00000021800	ENSONIP00000031986	Renin; Belongs to the peptidase A1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.503
LOC100691504	ctsc	ENSONIP00000021800	ENSONIP00000006441	Renin; Belongs to the peptidase A1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.490