(43 nodes) Mixed, incl. Regulation of beta-cell development, and Neuron fate specification network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I3IWB8_ORENI	BarH-like homeobox 1a. (275 aa)
	lhx4	LIM homeobox 4. (472 aa)
	LOC100691988	Hairy-related 12. (159 aa)
	ISL2	ISL LIM homeobox 2b. (364 aa)
	onecut1	One cut domain family member. (453 aa)
	LOC100704844	Uncharacterized protein. (477 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (315 aa)
	Vsx1	Visual system homeobox 1 homolog, chx10-like. (344 aa)
	Atoh7	Atonal bHLH transcription factor 7. (148 aa)
	LOC100712077	Homeobox domain-containing protein. (429 aa)
	foxn4	Forkhead box N4. (515 aa)
	LOC100712477	Uncharacterized protein. (384 aa)
	LOC100700683	ISL LIM homeobox 1. (351 aa)
	LHX3	LIM homeobox 3. (400 aa)
	ISL2-2	ISL LIM homeobox 2a. (363 aa)
	lhx5	LIM homeobox 5. (396 aa)
	LOC100711982	Iroquois homeobox 7. (386 aa)
	ptf1a	Pancreas associated transcription factor 1a. (273 aa)
	LOC100700859	Oligodendrocyte lineage transcription factor 2. (273 aa)
	LOC100706476	Homeobox domain-containing protein. (248 aa)
	barhl2	BarH-like homeobox 2. (365 aa)
	bhlhe22	Basic helix-loop-helix family, member e22. (242 aa)
	olig3	Oligodendrocyte transcription factor 3. (246 aa)
	NEUROD2	Neurogenic differentiation factor. (361 aa)
	LOC100710315	Insulinoma-associated 1b. (488 aa)
	LOC100696490	BHLH domain-containing protein. (312 aa)
	LOC100694743	BHLH domain-containing protein. (195 aa)
	LOC100702995	Neurogenin 1. (197 aa)
	ebf2	EBF transcription factor 2. (589 aa)
	nkx6-1	NK6 homeobox 1. (320 aa)
	LOC100703117	Myelin transcription factor 1. (1325 aa)
	LOC100711063	POU domain protein. (347 aa)
	LOC100696700	LIM homeobox transcription factor 1, alpha-like. (392 aa)
	I3JUP0_ORENI	POU domain protein. (351 aa)
	LOC100696266	LIM homeobox transcription factor 1, beta b. (411 aa)
	LOC100694496	Motor neuron and pancreas homeobox 2a. (323 aa)
	LOC100694572	Myelin transcription factor 1a. (1400 aa)
	neurod1	Neurogenic differentiation factor. (471 aa)
	I3JN05_ORENI	NK2 homeobox 2a. (254 aa)
	I3IY45_ORENI	LisH domain-containing protein. (355 aa)
	ENSONIP00000073744	Neurogenin 3. (229 aa)
	LOC100694969	Cugbp, Elav-like family member 3a. (483 aa)
	rfx6	Regulatory factor X, 6. (959 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atoh7	I3JUP0_ORENI	ENSONIP00000012933	ENSONIP00000040284	Atonal bHLH transcription factor 7.	POU domain protein.	0.570
Atoh7	LOC100691988	ENSONIP00000012933	ENSONIP00000002536	Atonal bHLH transcription factor 7.	Hairy-related 12.	0.501
Atoh7	LOC100712477	ENSONIP00000012933	ENSONIP00000017100	Atonal bHLH transcription factor 7.	Uncharacterized protein.	0.527
Atoh7	Vsx1	ENSONIP00000012933	ENSONIP00000008935	Atonal bHLH transcription factor 7.	Visual system homeobox 1 homolog, chx10-like.	0.644
Atoh7	foxn4	ENSONIP00000012933	ENSONIP00000016980	Atonal bHLH transcription factor 7.	Forkhead box N4.	0.519
ENSONIP00000073744	I3JN05_ORENI	ENSONIP00000073744	ENSONIP00000057746	Neurogenin 3.	NK2 homeobox 2a.	0.567
ENSONIP00000073744	LOC100691988	ENSONIP00000073744	ENSONIP00000002536	Neurogenin 3.	Hairy-related 12.	0.471
ENSONIP00000073744	LOC100706476	ENSONIP00000073744	ENSONIP00000023566	Neurogenin 3.	Homeobox domain-containing protein.	0.567
ENSONIP00000073744	LOC100710315	ENSONIP00000073744	ENSONIP00000026365	Neurogenin 3.	Insulinoma-associated 1b.	0.496
ENSONIP00000073744	mnx1	ENSONIP00000073744	ENSONIP00000007510	Neurogenin 3.	Motor neuron and pancreas homeobox 1.	0.401
ENSONIP00000073744	nkx6-1	ENSONIP00000073744	ENSONIP00000028248	Neurogenin 3.	NK6 homeobox 1.	0.593
ENSONIP00000073744	onecut1	ENSONIP00000073744	ENSONIP00000003332	Neurogenin 3.	One cut domain family member.	0.564
ENSONIP00000073744	rfx6	ENSONIP00000073744	ENSONIP00000075378	Neurogenin 3.	Regulatory factor X, 6.	0.505
I3IWB8_ORENI	ptf1a	ENSONIP00000000908	ENSONIP00000021410	BarH-like homeobox 1a.	Pancreas associated transcription factor 1a.	0.449
I3IY45_ORENI	LHX3	ENSONIP00000058336	ENSONIP00000018860	LisH domain-containing protein.	LIM homeobox 3.	0.444
I3IY45_ORENI	lhx4	ENSONIP00000058336	ENSONIP00000002400	LisH domain-containing protein.	LIM homeobox 4.	0.444
I3JN05_ORENI	ENSONIP00000073744	ENSONIP00000057746	ENSONIP00000073744	NK2 homeobox 2a.	Neurogenin 3.	0.567
I3JN05_ORENI	LOC100694743	ENSONIP00000057746	ENSONIP00000026591	NK2 homeobox 2a.	BHLH domain-containing protein.	0.426
I3JN05_ORENI	LOC100700859	ENSONIP00000057746	ENSONIP00000021534	NK2 homeobox 2a.	Oligodendrocyte lineage transcription factor 2.	0.558
I3JN05_ORENI	LOC100702995	ENSONIP00000057746	ENSONIP00000027863	NK2 homeobox 2a.	Neurogenin 1.	0.426