(7 nodes) Mixed, incl. Unstructured region on nuclear receptor coactivator protein, and NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I3J408_ORENI	Retinoid x receptor, beta b. (425 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	LOC100702127	Nuclear receptor subfamily 1, group D, member 2b. (594 aa)
	NCOA3	Nuclear receptor coactivator. (1521 aa)
	I3KWU7_ORENI	Nuclear receptor coactivator 3. (1514 aa)
	LOC100699579	Nuclear receptor subfamily 1, group H, member 5. (517 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (501 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3J408_ORENI	I3KWU7_ORENI	ENSONIP00000003598	ENSONIP00000025593	Retinoid x receptor, beta b.	Nuclear receptor coactivator 3.	0.736
I3J408_ORENI	LOC100699579	ENSONIP00000003598	ENSONIP00000033711	Retinoid x receptor, beta b.	Nuclear receptor subfamily 1, group H, member 5.	0.804
I3J408_ORENI	LOC100702127	ENSONIP00000003598	ENSONIP00000012960	Retinoid x receptor, beta b.	Nuclear receptor subfamily 1, group D, member 2b.	0.408
I3J408_ORENI	NCOA3	ENSONIP00000003598	ENSONIP00000021529	Retinoid x receptor, beta b.	Nuclear receptor coactivator.	0.736
I3J408_ORENI	PPARA	ENSONIP00000003598	ENSONIP00000072773	Retinoid x receptor, beta b.	Peroxisome proliferator-activated receptor alpha b.	0.773
I3J408_ORENI	nr1h3	ENSONIP00000003598	ENSONIP00000007341	Retinoid x receptor, beta b.	Nuclear receptor subfamily 1, group H, member 3.	0.921
I3KWU7_ORENI	I3J408_ORENI	ENSONIP00000025593	ENSONIP00000003598	Nuclear receptor coactivator 3.	Retinoid x receptor, beta b.	0.736
I3KWU7_ORENI	LOC100699579	ENSONIP00000025593	ENSONIP00000033711	Nuclear receptor coactivator 3.	Nuclear receptor subfamily 1, group H, member 5.	0.759
I3KWU7_ORENI	LOC100702127	ENSONIP00000025593	ENSONIP00000012960	Nuclear receptor coactivator 3.	Nuclear receptor subfamily 1, group D, member 2b.	0.714
I3KWU7_ORENI	PPARA	ENSONIP00000025593	ENSONIP00000072773	Nuclear receptor coactivator 3.	Peroxisome proliferator-activated receptor alpha b.	0.707
I3KWU7_ORENI	nr1h3	ENSONIP00000025593	ENSONIP00000007341	Nuclear receptor coactivator 3.	Nuclear receptor subfamily 1, group H, member 3.	0.848
LOC100699579	I3J408_ORENI	ENSONIP00000033711	ENSONIP00000003598	Nuclear receptor subfamily 1, group H, member 5.	Retinoid x receptor, beta b.	0.804
LOC100699579	I3KWU7_ORENI	ENSONIP00000033711	ENSONIP00000025593	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor coactivator 3.	0.759
LOC100699579	LOC100702127	ENSONIP00000033711	ENSONIP00000012960	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor subfamily 1, group D, member 2b.	0.769
LOC100699579	NCOA3	ENSONIP00000033711	ENSONIP00000021529	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor coactivator.	0.759
LOC100702127	I3J408_ORENI	ENSONIP00000012960	ENSONIP00000003598	Nuclear receptor subfamily 1, group D, member 2b.	Retinoid x receptor, beta b.	0.408
LOC100702127	I3KWU7_ORENI	ENSONIP00000012960	ENSONIP00000025593	Nuclear receptor subfamily 1, group D, member 2b.	Nuclear receptor coactivator 3.	0.714
LOC100702127	LOC100699579	ENSONIP00000012960	ENSONIP00000033711	Nuclear receptor subfamily 1, group D, member 2b.	Nuclear receptor subfamily 1, group H, member 5.	0.769
LOC100702127	NCOA3	ENSONIP00000012960	ENSONIP00000021529	Nuclear receptor subfamily 1, group D, member 2b.	Nuclear receptor coactivator.	0.714
LOC100702127	PPARA	ENSONIP00000012960	ENSONIP00000072773	Nuclear receptor subfamily 1, group D, member 2b.	Peroxisome proliferator-activated receptor alpha b.	0.637