(18 nodes) PGBD-like superfamily, and Negative regulation of membrane protein ectodomain proteolysis network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mmp15	Matrix metallopeptidase 15b. (655 aa)
	LOC100700935	ADAM metallopeptidase domain 17a. (851 aa)
	LOC100708330	Matrix metallopeptidase 20a (enamelysin). (473 aa)
	LOC100702284	TIMP metallopeptidase inhibitor 2b. (220 aa)
	LOC100695537	ZnMc domain-containing protein. (493 aa)
	I3K0D1_ORENI	Matrix metallopeptidase 17b. (620 aa)
	LOC100692615	Matrix metallopeptidase 11a. (496 aa)
	I3KM92_ORENI	ZnMc domain-containing protein. (410 aa)
	LOC100706082	Matrix metallopeptidase 25b. (575 aa)
	timp2	TIMP metallopeptidase inhibitor 2a. (220 aa)
	LOC100691693	Matrix metallopeptidase 14a (membrane-inserted). (556 aa)
	LOC100711125	ZnMc domain-containing protein. (475 aa)
	mmp9	Matrix metallopeptidase 9. (691 aa)
	LOC100705046	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (812 aa)
	furin	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (843 aa)
	mmp2	Matrix metallopeptidase 2. (657 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (285 aa)
	LOC100695964	Matrix metallopeptidase 14b (membrane-inserted). (644 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3K0D1_ORENI	LOC100702284	ENSONIP00000014576	ENSONIP00000006679	Matrix metallopeptidase 17b.	TIMP metallopeptidase inhibitor 2b.	0.633
I3K0D1_ORENI	LOC100708330	ENSONIP00000014576	ENSONIP00000006625	Matrix metallopeptidase 17b.	Matrix metallopeptidase 20a (enamelysin).	0.415
I3K0D1_ORENI	TIMP3	ENSONIP00000014576	ENSONIP00000056235	Matrix metallopeptidase 17b.	TIMP metallopeptidase inhibitor 3.	0.593
I3K0D1_ORENI	timp2	ENSONIP00000014576	ENSONIP00000029511	Matrix metallopeptidase 17b.	TIMP metallopeptidase inhibitor 2a.	0.633
I3KM92_ORENI	LOC100692615	ENSONIP00000022237	ENSONIP00000017526	ZnMc domain-containing protein.	Matrix metallopeptidase 11a.	0.494
I3KM92_ORENI	LOC100695537	ENSONIP00000022237	ENSONIP00000014159	ZnMc domain-containing protein.	ZnMc domain-containing protein.	0.483
I3KM92_ORENI	LOC100695964	ENSONIP00000022237	ENSONIP00000077870	ZnMc domain-containing protein.	Matrix metallopeptidase 14b (membrane-inserted).	0.535
I3KM92_ORENI	LOC100702284	ENSONIP00000022237	ENSONIP00000006679	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 2b.	0.652
I3KM92_ORENI	LOC100706082	ENSONIP00000022237	ENSONIP00000025295	ZnMc domain-containing protein.	Matrix metallopeptidase 25b.	0.421
I3KM92_ORENI	TIMP3	ENSONIP00000022237	ENSONIP00000056235	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 3.	0.654
I3KM92_ORENI	mmp15	ENSONIP00000022237	ENSONIP00000004003	ZnMc domain-containing protein.	Matrix metallopeptidase 15b.	0.533
I3KM92_ORENI	mmp9	ENSONIP00000022237	ENSONIP00000049921	ZnMc domain-containing protein.	Matrix metallopeptidase 9.	0.526
I3KM92_ORENI	timp2	ENSONIP00000022237	ENSONIP00000029511	ZnMc domain-containing protein.	TIMP metallopeptidase inhibitor 2a.	0.698
LOC100691693	LOC100695964	ENSONIP00000034809	ENSONIP00000077870	Matrix metallopeptidase 14a (membrane-inserted).	Matrix metallopeptidase 14b (membrane-inserted).	0.901
LOC100691693	LOC100702284	ENSONIP00000034809	ENSONIP00000006679	Matrix metallopeptidase 14a (membrane-inserted).	TIMP metallopeptidase inhibitor 2b.	0.640
LOC100691693	TIMP3	ENSONIP00000034809	ENSONIP00000056235	Matrix metallopeptidase 14a (membrane-inserted).	TIMP metallopeptidase inhibitor 3.	0.593
LOC100691693	mmp2	ENSONIP00000034809	ENSONIP00000056011	Matrix metallopeptidase 14a (membrane-inserted).	Matrix metallopeptidase 2.	0.929
LOC100691693	timp2	ENSONIP00000034809	ENSONIP00000029511	Matrix metallopeptidase 14a (membrane-inserted).	TIMP metallopeptidase inhibitor 2a.	0.645
LOC100692615	I3KM92_ORENI	ENSONIP00000017526	ENSONIP00000022237	Matrix metallopeptidase 11a.	ZnMc domain-containing protein.	0.494
LOC100692615	LOC100702284	ENSONIP00000017526	ENSONIP00000006679	Matrix metallopeptidase 11a.	TIMP metallopeptidase inhibitor 2b.	0.596