(27 nodes) Preribosome, large subunit precursor, and Maturation of LSU-rRNA network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	wdr74	WD repeat domain 74. (375 aa)
	ftsj3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (858 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (750 aa)
	rpf1	Ribosome production factor 1 homolog. (349 aa)
	Brix1	Brix domain containing 2. (358 aa)
	ddx18	RNA helicase. (656 aa)
	cep152	Centrosomal protein 152. (1664 aa)
	Nop2	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (587 aa)
	wdr12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (421 aa)
	mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
	gnl2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (732 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (465 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (635 aa)
	gnl3	Guanine nucleotide binding protein-like 3 (nucleolar). (556 aa)
	Rsl1d1	Ribosomal L1 domain containing 1. (233 aa)
	LOC100711132	Nucleolar protein interacting with the FHA domain of MKI67. (285 aa)
	nsa2	NSA2 ribosome biogenesis homolog (S. cerevisiae). (260 aa)
	LOC100690727	Ribosomal RNA processing 1. (861 aa)
	pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (586 aa)
	rpf2	Ribosome production factor 2 homolog. (331 aa)
	nip7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (202 aa)
	mak16	Protein MAK16 homolog; Belongs to the MAK16 family. (306 aa)
	rsl24d1	Ribosomal L24 domain containing 1. (164 aa)
	ebna1bp2	EBNA1 binding protein 2. (314 aa)
	gnl3l	Guanine nucleotide-binding protein-like 3-like protein isoform X2. (566 aa)
	bop1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (719 aa)
	noc3l	Nucleolar complex protein 3 homolog. (802 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brix1	LOC100690727	ENSONIP00000009737	ENSONIP00000032227	Brix domain containing 2.	Ribosomal RNA processing 1.	0.998
Brix1	LOC100711132	ENSONIP00000009737	ENSONIP00000027780	Brix domain containing 2.	Nucleolar protein interacting with the FHA domain of MKI67.	0.999
Brix1	Nop2	ENSONIP00000009737	ENSONIP00000016227	Brix domain containing 2.	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.970
Brix1	Rsl1d1	ENSONIP00000009737	ENSONIP00000024869	Brix domain containing 2.	Ribosomal L1 domain containing 1.	0.995
Brix1	bop1	ENSONIP00000009737	ENSONIP00000075411	Brix domain containing 2.	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.977
Brix1	cep152	ENSONIP00000009737	ENSONIP00000010538	Brix domain containing 2.	Centrosomal protein 152.	0.977
Brix1	ddx18	ENSONIP00000009737	ENSONIP00000009943	Brix domain containing 2.	RNA helicase.	0.992
Brix1	ebna1bp2	ENSONIP00000009737	ENSONIP00000068299	Brix domain containing 2.	EBNA1 binding protein 2.	0.999
Brix1	ftsj3	ENSONIP00000009737	ENSONIP00000002074	Brix domain containing 2.	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.	0.959
Brix1	gnl2	ENSONIP00000009737	ENSONIP00000020509	Brix domain containing 2.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.955
Brix1	gnl3	ENSONIP00000009737	ENSONIP00000024337	Brix domain containing 2.	Guanine nucleotide binding protein-like 3 (nucleolar).	0.971
Brix1	gnl3l	ENSONIP00000009737	ENSONIP00000075317	Brix domain containing 2.	Guanine nucleotide-binding protein-like 3-like protein isoform X2.	0.971
Brix1	gtpbp4	ENSONIP00000009737	ENSONIP00000022327	Brix domain containing 2.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.995
Brix1	mak16	ENSONIP00000009737	ENSONIP00000062268	Brix domain containing 2.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.984
Brix1	mrto4	ENSONIP00000009737	ENSONIP00000018003	Brix domain containing 2.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.991
Brix1	nip7	ENSONIP00000009737	ENSONIP00000058957	Brix domain containing 2.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.996
Brix1	noc2l	ENSONIP00000009737	ENSONIP00000003003	Brix domain containing 2.	NOC2-like nucleolar associated transcriptional repressor.	0.994
Brix1	noc3l	ENSONIP00000009737	ENSONIP00000080815	Brix domain containing 2.	Nucleolar complex protein 3 homolog.	0.994
Brix1	nop53	ENSONIP00000009737	ENSONIP00000020940	Brix domain containing 2.	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.	0.801
Brix1	nsa2	ENSONIP00000009737	ENSONIP00000028063	Brix domain containing 2.	NSA2 ribosome biogenesis homolog (S. cerevisiae).	0.974