(123 nodes) Regulation of cell-substrate adhesion network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I3J121_ORENI	Chondroitin sulfate proteoglycan 5b. (684 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (305 aa)
	LOC100698775	Zgc:77748. (275 aa)
	spry4	Protein sprouty homolog 4. (382 aa)
	LOC100702843	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (952 aa)
	tsta3	Tissue specific transplantation antigen P35B. (345 aa)
	LOC100699048	Myeloid-associated differentiation marker homolog. (287 aa)
	fermt1	Fermitin family member 1. (700 aa)
	arl2	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	ECM2	Extracellular matrix protein 2. (934 aa)
	ENSONIP00000000885	TSC complex subunit 1a. (924 aa)
	wdpcp	WD repeat containing planar cell polarity effector. (740 aa)
	LOC100708867	EMILIN-1. (1023 aa)
	myoc	Myocilin. (482 aa)
	LOC100707680	Elastin microfibril interfacer 1b. (1137 aa)
	I3J5B3_ORENI	Cas scaffold protein family member 4. (726 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (999 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (202 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
	LOC102078035	Collagen type XXVI alpha 1 chain. (432 aa)
	Bcar1	BCAR1 scaffold protein, Cas family member. (984 aa)
	LOC100689834	Fibronectin 1a. (2501 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
	LOC100701341	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	LOC100701613	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (184 aa)
	LOC100691161	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	LOC100691432	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	ajap1	Adherens junctions associated protein 1. (391 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	LOC100705444	Uncharacterized protein. (189 aa)
	LOC100705703	Uncharacterized protein. (190 aa)
	LOC100707172	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (612 aa)
	ccn1	Cellular communication network factor 1. (379 aa)
	LOC100696389	Uncharacterized protein. (320 aa)
	LOC100707163	Vinculin a. (1158 aa)
	LOC100701197	Calponin-homology (CH) domain-containing protein. (1802 aa)
	LOC100711975	Eph receptor A4b. (984 aa)
	vwc2	Von Willebrand factor C domain containing 2. (307 aa)
	LOC100705099	CRK proto-oncogene, adaptor protein. (315 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (375 aa)
	dab2	DAB adaptor protein 2. (782 aa)
	LOC102077543	Si:dkey-32e6.6. (424 aa)
	LOC100706624	Ephrin-A5a; Belongs to the ephrin family. (229 aa)
	tesk1	Si:dkeyp-75h12.2. (689 aa)
	rreb1	Ras responsive element binding protein 1a. (1889 aa)
	plekha2	Si:ch211-204d2.4. (430 aa)
	Nedd9	Neural precursor cell expressed, developmentally down-regulated 9. (756 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (189 aa)
	Nf1	Neurofibromin 1b. (2742 aa)
	rsu1	Ras suppressor protein 1. (283 aa)
	LOC100707995	Testis associated actin remodelling kinase 2. (623 aa)
	ptk2b	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (989 aa)
	ap1ar	Adaptor related protein complex 1 associated regulatory protein. (297 aa)
	agr2	Anterior gradient 2. (167 aa)
	Egfl6	EGF-like-domain, multiple 6. (490 aa)
	SPOCK2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (415 aa)
	ccdc80	Coiled-coil domain containing 80. (885 aa)
	LOC100708634	Apolipoprotein A-Ib. (263 aa)
	RAC2	Rac family small GTPase 2. (205 aa)
	LOC100696401	Ras-related C3 botulinum toxin substrate 1-like. (209 aa)
	I3KLB2_ORENI	Uncharacterized protein. (200 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (288 aa)
	LOC100699682	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (417 aa)
	LOC100707936	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (211 aa)
	LOC100698589	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (186 aa)
	LOC100707214	Junction plakoglobin a. (728 aa)
	RAC1	Rac family small GTPase 1. (201 aa)
	LOC100709732	Olfactomedin-like domain-containing protein. (463 aa)
	I3KWE7_ORENI	Si:ch211-173a9.6. (426 aa)
	ptpra	Receptor-type tyrosine-protein phosphatase alpha. (824 aa)
	ENSONIP00000026292	Si:dkeyp-66d1.7. (291 aa)
	GREM1	Gremlin. (182 aa)
	LOC100695354	Uncharacterized protein. (279 aa)
	LOC100706019	Gremlin 1a, DAN family BMP antagonist. (236 aa)
	nexmif	Neurite extension and migration factor b. (1506 aa)
	LOC100701331	Uncharacterized protein. (772 aa)
	LOC100695462	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (145 aa)
	disc1	DISC1 scaffold protein. (755 aa)
	ENSONIP00000029976	LIM and calponin homology domains 1b. (1282 aa)
	RIN2	Ras and Rab interactor 2. (985 aa)
	FBLN2	Fibulin 2. (1225 aa)
	I3KUM9_ORENI	Protein S100; Belongs to the S-100 family. (138 aa)
	lrrc45	Leucine rich repeat containing 45. (674 aa)
	ndnf	Neuron-derived neurotrophic factor. (572 aa)
	cdc42	Cell division cycle 42. (209 aa)
	Vegfa	Vascular endothelial growth factor A isoform X3. (201 aa)
	Cspg5	Chondroitin sulfate proteoglycan 5a. (625 aa)
	EMID1	EMI domain-containing protein. (508 aa)
	LOC100690920	Fibulin-2 isoform X1. (1368 aa)
	I3JID5_ORENI	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1044 aa)
	LOC100703229	Protein kinase domain-containing protein. (733 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1063 aa)
	vtn	Vitronectin a. (562 aa)
	LOC100701917	Uncharacterized protein. (496 aa)
	LOC100692620	LIM domain-containing protein. (406 aa)
	LOC100692624	Vitronectin b. (437 aa)
	ARHGAP6	Rho GTPase activating protein 6. (751 aa)
	ENSONIP00000048570	annotation not available (155 aa)
	LOC100691030	Uncharacterized protein LOC100691030. (701 aa)
	LOC100697214	Ras and Rab interactor 2. (1107 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (950 aa)
	LOC102076914	Neuron-derived neurotrophic factor, like. (582 aa)
	LOC100704495	TSC complex subunit 1b. (1275 aa)
	LOC100696773	Uncharacterized protein. (302 aa)
	bcas3	BCAS3 microtubule associated cell migration factor. (995 aa)
	LOC100692912	Olfactomedin-like domain-containing protein. (461 aa)
	tbcd	Tubulin folding cofactor D. (1198 aa)
	ENSONIP00000057298	Rac family small GTPase 3b. (193 aa)
	EGFLAM	EGF like, fibronectin type III and laminin G domains. (1092 aa)
	LOC100693503	Calcium/calmodulin-dependent serine protein kinase b; Belongs to the MAGUK family. (944 aa)
	ENSONIP00000061327	C-C motif chemokine 20. (119 aa)
	LOC100696557	Uncharacterized protein. (191 aa)
	ENSONIP00000063824	annotation not available (102 aa)
	I3J3T9_ORENI	Protein tyrosine kinase 2. (1167 aa)
	I3KYU5_ORENI	Si:dkeyp-66d1.7. (340 aa)
	ILK	Integrin linked kinase. (460 aa)
	LOC100712562	Uncharacterized protein. (191 aa)
	ABI3BP	Uncharacterized protein. (1407 aa)
	Vcl	Vinculin b. (1097 aa)
	LOC100698578	LIM domain-containing protein. (374 aa)
	I3JIW9_ORENI	Uncharacterized protein. (195 aa)
	LOC100712331	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (545 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (230 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP6	ENSONIP00000048570	ENSONIP00000048366	ENSONIP00000048570	Rho GTPase activating protein 6.	annotation not available	0.403
ARHGAP6	Egfl6	ENSONIP00000048366	ENSONIP00000020218	Rho GTPase activating protein 6.	EGF-like-domain, multiple 6.	0.472
ARHGAP6	I3JIW9_ORENI	ENSONIP00000048366	ENSONIP00000070955	Rho GTPase activating protein 6.	Uncharacterized protein.	0.403
ARHGAP6	LOC100696557	ENSONIP00000048366	ENSONIP00000061896	Rho GTPase activating protein 6.	Uncharacterized protein.	0.403
ARHGAP6	LOC100705444	ENSONIP00000048366	ENSONIP00000008814	Rho GTPase activating protein 6.	Uncharacterized protein.	0.403
ARHGAP6	LOC100705703	ENSONIP00000048366	ENSONIP00000008815	Rho GTPase activating protein 6.	Uncharacterized protein.	0.403
ARHGAP6	LOC100712562	ENSONIP00000048366	ENSONIP00000067416	Rho GTPase activating protein 6.	Uncharacterized protein.	0.403
ARHGAP6	cdc42	ENSONIP00000048366	ENSONIP00000037546	Rho GTPase activating protein 6.	Cell division cycle 42.	0.462
Bcar1	ENSONIP00000057298	ENSONIP00000005122	ENSONIP00000057298	BCAR1 scaffold protein, Cas family member.	Rac family small GTPase 3b.	0.414
Bcar1	I3J3T9_ORENI	ENSONIP00000005122	ENSONIP00000065383	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2.	0.718
Bcar1	I3JID5_ORENI	ENSONIP00000005122	ENSONIP00000042855	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.718
Bcar1	LOC100689834	ENSONIP00000005122	ENSONIP00000005505	BCAR1 scaffold protein, Cas family member.	Fibronectin 1a.	0.447
Bcar1	LOC100696389	ENSONIP00000005122	ENSONIP00000011957	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein.	0.977
Bcar1	LOC100696401	ENSONIP00000005122	ENSONIP00000021627	BCAR1 scaffold protein, Cas family member.	Ras-related C3 botulinum toxin substrate 1-like.	0.414
Bcar1	LOC100702843	ENSONIP00000005122	ENSONIP00000076654	BCAR1 scaffold protein, Cas family member.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.718
Bcar1	LOC100705099	ENSONIP00000005122	ENSONIP00000013668	BCAR1 scaffold protein, Cas family member.	CRK proto-oncogene, adaptor protein.	0.977
Bcar1	LOC100707163	ENSONIP00000005122	ENSONIP00000012116	BCAR1 scaffold protein, Cas family member.	Vinculin a.	0.575
Bcar1	RAC1	ENSONIP00000005122	ENSONIP00000024982	BCAR1 scaffold protein, Cas family member.	Rac family small GTPase 1.	0.414
Bcar1	RAC2	ENSONIP00000005122	ENSONIP00000021368	BCAR1 scaffold protein, Cas family member.	Rac family small GTPase 2.	0.414
Bcar1	Vcl	ENSONIP00000005122	ENSONIP00000069494	BCAR1 scaffold protein, Cas family member.	Vinculin b.	0.575