(40 nodes) snRNA binding network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (127 aa)
	ENSONIP00000075314	annotation not available (120 aa)
	rbm22	RNA binding motif protein 22. (427 aa)
	toe1	Target of EGR1, exonuclease. (545 aa)
	rbm41	RNA binding motif protein 41. (449 aa)
	snrpa	Small nuclear ribonucleoprotein polypeptide A. (282 aa)
	rbmx	RNA binding motif protein X-linked. (391 aa)
	ENSONIP00000000466	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated. (107 aa)
	snrpb2	Small nuclear ribonucleoprotein polypeptide B2. (218 aa)
	prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast). (482 aa)
	coil	Coilin p80. (569 aa)
	Sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (997 aa)
	gemin5	Gem (nuclear organelle) associated protein 5. (1466 aa)
	LOC100712087	Uncharacterized protein. (182 aa)
	lsm11	LSM11, U7 small nuclear RNA associated. (338 aa)
	lrmda	Leucine rich melanocyte differentiation associated. (233 aa)
	ro60	Ro60, Y RNA binding protein. (553 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (121 aa)
	LOC100695640	HEXIM P-TEFb complex subunit 1. (361 aa)
	snrnp35	Small nuclear ribonucleoprotein 35 (U11/U12). (237 aa)
	LOC100704258	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	ENSONIP00000031680	Nuclear cap-binding protein subunit 2-like. (120 aa)
	LOC100706293	Leucine rich repeat containing 51. (263 aa)
	larp7	La ribonucleoprotein domain family, member 7. (568 aa)
	LOC100698210	Cyclin T2; Belongs to the cyclin family. (708 aa)
	ENSONIP00000046810	Nuclear cap-binding protein subunit 2-like. (91 aa)
	LOC100690070	Cyclin T1; Belongs to the cyclin family. (702 aa)
	eftud2	Elongation factor Tu GTP binding domain containing 2. (1011 aa)
	Snu13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (221 aa)
	mettl16	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (590 aa)
	I3JRJ0_ORENI	Bin3-type SAM domain-containing protein. (429 aa)
	LOC100702413	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (164 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (602 aa)
	LOC100690123	Methylphosphate capping enzyme. (753 aa)
	prpf8	Pre-mRNA processing factor 8. (2350 aa)
	sf3b3	Splicing factor 3b, subunit 3. (1217 aa)
	Snrpa1	Small nuclear ribonucleoprotein polypeptide A. (291 aa)
	LOC100709139	Cyclin T2b; Belongs to the cyclin family. (610 aa)
	prpf4	PRP4 pre-mRNA processing factor 4 homolog (yeast). (523 aa)
	lsm4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (147 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000000466	ENSONIP00000031680	ENSONIP00000000466	ENSONIP00000031680	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Nuclear cap-binding protein subunit 2-like.	0.502
ENSONIP00000000466	ENSONIP00000046810	ENSONIP00000000466	ENSONIP00000046810	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Nuclear cap-binding protein subunit 2-like.	0.502
ENSONIP00000000466	ENSONIP00000075314	ENSONIP00000000466	ENSONIP00000075314	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	annotation not available	0.502
ENSONIP00000000466	LOC100702413	ENSONIP00000000466	ENSONIP00000071076	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.502
ENSONIP00000000466	LOC100706293	ENSONIP00000000466	ENSONIP00000039827	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Leucine rich repeat containing 51.	0.616
ENSONIP00000000466	LOC100712087	ENSONIP00000000466	ENSONIP00000020716	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Uncharacterized protein.	0.616
ENSONIP00000000466	LSM10	ENSONIP00000000466	ENSONIP00000026207	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	LSM10, U7 small nuclear RNA associated.	0.807
ENSONIP00000000466	Sart3	ENSONIP00000000466	ENSONIP00000016863	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Spliceosome associated factor 3, U4/U6 recycling protein.	0.889
ENSONIP00000000466	Snrpa1	ENSONIP00000000466	ENSONIP00000014349	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Small nuclear ribonucleoprotein polypeptide A.	0.865
ENSONIP00000000466	Snu13	ENSONIP00000000466	ENSONIP00000059762	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.880
ENSONIP00000000466	eftud2	ENSONIP00000000466	ENSONIP00000055002	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Elongation factor Tu GTP binding domain containing 2.	0.881
ENSONIP00000000466	lrmda	ENSONIP00000000466	ENSONIP00000023326	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Leucine rich melanocyte differentiation associated.	0.616
ENSONIP00000000466	lsm4	ENSONIP00000000466	ENSONIP00000016014	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.972
ENSONIP00000000466	prpf31	ENSONIP00000000466	ENSONIP00000008297	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	PRP31 pre-mRNA processing factor 31 homolog (yeast).	0.925
ENSONIP00000000466	prpf4	ENSONIP00000000466	ENSONIP00000015948	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	PRP4 pre-mRNA processing factor 4 homolog (yeast).	0.885
ENSONIP00000000466	prpf8	ENSONIP00000000466	ENSONIP00000010265	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Pre-mRNA processing factor 8.	0.889
ENSONIP00000000466	rbm22	ENSONIP00000000466	ENSONIP00000016411	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	RNA binding motif protein 22.	0.523
ENSONIP00000000466	rbm41	ENSONIP00000000466	ENSONIP00000016673	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	RNA binding motif protein 41.	0.607
ENSONIP00000000466	rnpc3	ENSONIP00000000466	ENSONIP00000071546	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	RNA-binding region (RNP1, RRM) containing 3.	0.607
ENSONIP00000000466	sf3b3	ENSONIP00000000466	ENSONIP00000014093	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated.	Splicing factor 3b, subunit 3.	0.773