(128 nodes) Ubiquitin-like protein peptidase activity network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	josd1	Josephin domain containing 1. (266 aa)
	LOC100700930	Ubiquitin specific peptidase 18; Belongs to the peptidase C19 family. (375 aa)
	usp45	Ubiquitin carboxyl-terminal hydrolase. (823 aa)
	usp50	Ubiquitin carboxyl-terminal hydrolase. (769 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (931 aa)
	ZRANB1	Zinc finger RANBP2-type containing 1. (799 aa)
	usp40	Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1290 aa)
	usp31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1280 aa)
	usp19	Ubiquitin specific peptidase 19. (1517 aa)
	mindy4	Si:dkey-30h22.11. (694 aa)
	COPS6	COP9 signalosome subunit 6. (316 aa)
	USP24	Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. (2624 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (956 aa)
	mindy3	MINDY lysine 48 deubiquitinase 3. (455 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (333 aa)
	mindy1	MINDY lysine 48 deubiquitinase 1. (554 aa)
	usp16	Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (859 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1383 aa)
	otulin	Uncharacterized protein. (729 aa)
	eif3h	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (341 aa)
	USP53	Ubiquitin specific peptidase 53. (1034 aa)
	usp48	Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1050 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (830 aa)
	otud3	OTU deubiquitinase 3. (358 aa)
	I3JSG4_ORENI	ULP_PROTEASE domain-containing protein. (290 aa)
	usp38	Ubiquitin specific peptidase 38; Belongs to the peptidase C19 family. (1034 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (332 aa)
	vcpip1	Valosin containing protein (p97)/p47 complex interacting protein 1. (1177 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3465 aa)
	uspl1	Ubiquitin specific peptidase like 1. (1149 aa)
	josd2	Josephin domain containing 2. (183 aa)
	usp5	Ubiquitin carboxyl-terminal hydrolase. (848 aa)
	usp39	Ubiquitin specific peptidase 39. (501 aa)
	LOC100703809	Si:dkey-206d17.12. (643 aa)
	LOC100700731	STAM binding protein b. (432 aa)
	bap1	Ubiquitin carboxyl-terminal hydrolase. (743 aa)
	Otud5	OTU deubiquitinase 5a. (537 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (337 aa)
	usp3	Ubiquitin carboxyl-terminal hydrolase. (623 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1115 aa)
	usp25	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1144 aa)
	LOC100702646	Zinc finger CCCH-type containing 12A. (632 aa)
	I3KJB2_ORENI	Ubiquitin carboxyl-terminal hydrolase. (899 aa)
	cep112	Centrosomal protein 112. (934 aa)
	I3KKW6_ORENI	MINDY family member 4B. (356 aa)
	LOC100699853	Ubiquitin specific peptidase 53b. (1045 aa)
	SENP6	ULP_PROTEASE domain-containing protein. (1114 aa)
	usp49	Ubiquitin carboxyl-terminal hydrolase. (668 aa)
	stambpl1	STAM binding protein-like 1. (442 aa)
	LOC100707081	DUF862 domain-containing protein. (197 aa)
	LOC100699528	Desumoylating isopeptidase 1b. (177 aa)
	usp42	Ubiquitin specific peptidase 42; Belongs to the peptidase C19 family. (1055 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1312 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (227 aa)
	LOC100700586	Ataxin 3. (348 aa)
	senp8	SUMO peptidase family member, NEDD8 specific. (221 aa)
	ufsp1	UFM1-specific peptidase 1 (non-functional). (272 aa)
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
	LOC100708900	Si:dkey-21c19.3. (732 aa)
	LOC102081153	Proline-rich transmembrane protein 4. (943 aa)
	ENSONIP00000028111	annotation not available (350 aa)
	I3JX89_ORENI	ULP_PROTEASE domain-containing protein. (234 aa)
	cops4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (421 aa)
	usp28	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1231 aa)
	ENSONIP00000030651	annotation not available (292 aa)
	LOC100706784	Ubiquitin carboxyl-terminal hydrolase. (394 aa)
	otub1	Ubiquitin thioesterase. (279 aa)
	I3JUM1_ORENI	ULP_PROTEASE domain-containing protein. (249 aa)
	I3JCU4_ORENI	Ubiquitin carboxyl-terminal hydrolase. (1008 aa)
	Ufsp2	Ufm1-specific peptidase 2. (935 aa)
	mindy2	Ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1. (667 aa)
	Prrt4	Proline-rich transmembrane protein 4. (1170 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (892 aa)
	otud7b	OTU deubiquitinase 7B. (920 aa)
	LOC100707393	Desumoylating isopeptidase 1a. (168 aa)
	usp12	Ubiquitin specific peptidase 12a; Belongs to the peptidase C19 family. (374 aa)
	I3JCM6_ORENI	Ubiquitinyl hydrolase 1. (535 aa)
	ENSONIP00000041204	SUMO specific peptidase 2. (568 aa)
	LOC102079555	Proline-rich transmembrane protein 3. (705 aa)
	LOC102081728	Uncharacterized LOC102081728. (1097 aa)
	LOC100693654	Uncharacterized protein. (974 aa)
	LOC102080067	Proline-rich transmembrane protein 3. (1055 aa)
	USP15	Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (946 aa)
	usp14	Ubiquitin carboxyl-terminal hydrolase. (544 aa)
	ENSONIP00000043960	annotation not available (292 aa)
	cops5	COP9 signalosome subunit 5. (360 aa)
	usp4	Ubiquitin carboxyl-terminal hydrolase. (999 aa)
	ENSONIP00000045390	Ubiquitin thioesterase OTU1-like. (301 aa)
	I3KFT1_ORENI	Ubiquitin specific peptidase 54b. (1328 aa)
	EIF3S5	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (349 aa)
	senp7	ULP_PROTEASE domain-containing protein. (1040 aa)
	Desi2	Desumoylating isopeptidase 2. (209 aa)
	LOC100690273	Ubiquitin carboxyl-terminal hydrolase 43. (1222 aa)
	LOC100695402	Ubiquitin specific peptidase 43a; Belongs to the peptidase C19 family. (1546 aa)
	ENSONIP00000055289	annotation not available (324 aa)
	mysm1	Myb-like, SWIRM and MPN domains 1. (916 aa)
	otud6b	OTU domain containing 6B. (315 aa)
	usp44	Ubiquitin carboxyl-terminal hydrolase. (768 aa)
	ENSONIP00000057115	Ubiquitin carboxyl-terminal hydrolase CYLD. (784 aa)
	ENSONIP00000058114	annotation not available (268 aa)
	LOC100701166	OTU deubiquitinase 7A. (958 aa)
	ENSONIP00000058826	annotation not available (338 aa)
	LOC100700811	Ubiquitin carboxyl-terminal hydrolase CYLD. (701 aa)
	LOC100705341	Ubiquitin carboxyl-terminal hydrolase 19 isoform X1. (835 aa)
	usp20	Ubiquitin carboxyl-terminal hydrolase. (943 aa)
	LOC100693926	Uncharacterized protein. (118 aa)
	LOC100696501	Uncharacterized protein LOC100696501. (551 aa)
	LOC100695864	Ubiquitin carboxyl-terminal hydrolase. (439 aa)
	usp46	Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (370 aa)
	ENSONIP00000064683	annotation not available (292 aa)
	usp33	Ubiquitin carboxyl-terminal hydrolase. (915 aa)
	USP22	Ubiquitin carboxyl-terminal hydrolase. (550 aa)
	LOC100690469	Ubiquitin thioesterase OTU1 isoform X1. (301 aa)
	otud1	OTU domain-containing protein 1. (453 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (861 aa)
	I3KBS9_ORENI	Ubiquitin carboxyl-terminal hydrolase. (1003 aa)
	ENSONIP00000071413	annotation not available (292 aa)
	Zranb1	Zinc finger, RAN-binding domain containing 1a. (759 aa)
	uchl1	Ubiquitin carboxyl-terminal hydrolase. (220 aa)
	LOC100694066	Ubiquitin carboxyl-terminal hydrolase 21. (404 aa)
	LOC102081408	Ubiquitin carboxyl-terminal hydrolase 17-like protein D isoform X1. (674 aa)
	usp13	Ubiquitinyl hydrolase 1. (879 aa)
	usp30	Ubiquitin carboxyl-terminal hydrolase. (504 aa)
	ENSONIP00000075860	annotation not available (298 aa)
	usp9x	Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2612 aa)
	mpnd	MPN domain containing. (494 aa)
	LOC100708948	USP domain-containing protein; Belongs to the peptidase C19 family. (602 aa)
	usp32	Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family. (1599 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COPS6	EIF3S5	ENSONIP00000002959	ENSONIP00000045699	COP9 signalosome subunit 6.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.568
COPS6	bap1	ENSONIP00000002959	ENSONIP00000018196	COP9 signalosome subunit 6.	Ubiquitin carboxyl-terminal hydrolase.	0.657
COPS6	cops4	ENSONIP00000002959	ENSONIP00000029082	COP9 signalosome subunit 6.	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).	0.999
COPS6	cops5	ENSONIP00000002959	ENSONIP00000043994	COP9 signalosome subunit 6.	COP9 signalosome subunit 5.	0.999
COPS6	eif3h	ENSONIP00000002959	ENSONIP00000009070	COP9 signalosome subunit 6.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.896
COPS6	mysm1	ENSONIP00000002959	ENSONIP00000055805	COP9 signalosome subunit 6.	Myb-like, SWIRM and MPN domains 1.	0.594
COPS6	psmd14	ENSONIP00000002959	ENSONIP00000004194	COP9 signalosome subunit 6.	Proteasome 26S subunit, non-ATPase 14.	0.574
COPS6	psmd7	ENSONIP00000002959	ENSONIP00000018681	COP9 signalosome subunit 6.	Proteasome 26S subunit, non-ATPase 7.	0.477
COPS6	senp8	ENSONIP00000002959	ENSONIP00000025754	COP9 signalosome subunit 6.	SUMO peptidase family member, NEDD8 specific.	0.470
COPS6	uchl5	ENSONIP00000002959	ENSONIP00000013777	COP9 signalosome subunit 6.	Ubiquitin carboxyl-terminal hydrolase.	0.684
COPS6	usp14	ENSONIP00000002959	ENSONIP00000043012	COP9 signalosome subunit 6.	Ubiquitin carboxyl-terminal hydrolase.	0.677
EIF3S5	COPS6	ENSONIP00000045699	ENSONIP00000002959	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 signalosome subunit 6.	0.568
EIF3S5	bap1	ENSONIP00000045699	ENSONIP00000018196	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ubiquitin carboxyl-terminal hydrolase.	0.685
EIF3S5	brcc3	ENSONIP00000045699	ENSONIP00000026355	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	BRCA1/BRCA2-containing complex, subunit 3.	0.433
EIF3S5	cops4	ENSONIP00000045699	ENSONIP00000029082	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).	0.916
EIF3S5	cops5	ENSONIP00000045699	ENSONIP00000043994	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	COP9 signalosome subunit 5.	0.737
EIF3S5	eif3h	ENSONIP00000045699	ENSONIP00000009070	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
EIF3S5	mpnd	ENSONIP00000045699	ENSONIP00000077773	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	MPN domain containing.	0.551
EIF3S5	mysm1	ENSONIP00000045699	ENSONIP00000055805	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Myb-like, SWIRM and MPN domains 1.	0.607
EIF3S5	psmd14	ENSONIP00000045699	ENSONIP00000004194	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Proteasome 26S subunit, non-ATPase 14.	0.660