44 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSONIP00000039182	annotation not available (169 aa)
	Haspin	Serine/threonine-protein kinase haspin isoform X1. (1242 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	I3KE98_ORENI	Zwilch kinetochore protein. (521 aa)
	LOC100706117	Aurora kinase B; Belongs to the protein kinase superfamily. (290 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (599 aa)
	Ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (186 aa)
	cdc26	Cell division cycle 26 homolog. (97 aa)
	bub1	BUB1 mitotic checkpoint serine/threonine kinase. (1266 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (621 aa)
	cenpe	Centromere-associated protein E isoform X1. (2524 aa)
	rb1	Retinoblastoma 1. (919 aa)
	mad2l1bp	MAD2L1 binding protein. (425 aa)
	zw10	Zw10 kinetochore protein. (766 aa)
	ttk	Ttk protein kinase. (997 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (604 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (720 aa)
	xrcc3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (340 aa)
	LOC100701209	Zinc finger protein 207. (430 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (446 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (434 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (556 aa)
	I3K6J4_ORENI	Uncharacterized protein. (849 aa)
	riok2	RIO kinase 2 (yeast). (524 aa)
	Ndc80	NDC80 kinetochore complex component. (650 aa)
	I3KDT0_ORENI	BAF chromatin remodeling complex subunit BCL7A. (168 aa)
	anapc7	Anaphase promoting complex subunit 7. (580 aa)
	bub3	BUB3 mitotic checkpoint protein. (341 aa)
	LOC100694797	Translocated promoter region a, nuclear basket protein. (2505 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	anapc4	Anaphase promoting complex subunit 4. (808 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	atm	Non-specific serine/threonine protein kinase. (3095 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	I3JLZ1_ORENI	SMYLE_N domain-containing protein. (1037 aa)
	cdc27	Cell division cycle 27. (803 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (2364 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	ENSONIP00000012749	annotation not available (1687 aa)
	klhl22	Kelch-like family member 22. (638 aa)
	anapc5	Anaphase promoting complex subunit 5. (771 aa)
	ZNF207	Zinc finger protein 207, b. (466 aa)
	lcmt1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (325 aa)
	LOC109194151	CULLIN_2 domain-containing protein; Belongs to the cullin family. (767 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL3	LOC100706117	ENSONIP00000012629	ENSONIP00000056574	Cullin 3; Belongs to the cullin family.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.662
CUL3	LOC109194151	ENSONIP00000012629	ENSONIP00000040048	Cullin 3; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
CUL3	Ube2c	ENSONIP00000012629	ENSONIP00000067932	Cullin 3; Belongs to the cullin family.	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family.	0.505
CUL3	cdc27	ENSONIP00000012629	ENSONIP00000011559	Cullin 3; Belongs to the cullin family.	Cell division cycle 27.	0.419
CUL3	cdt1	ENSONIP00000012629	ENSONIP00000016535	Cullin 3; Belongs to the cullin family.	Chromatin licensing and DNA replication factor 1.	0.458
CUL3	klhl22	ENSONIP00000012629	ENSONIP00000013871	Cullin 3; Belongs to the cullin family.	Kelch-like family member 22.	0.813
CUL3	rb1	ENSONIP00000012629	ENSONIP00000076566	Cullin 3; Belongs to the cullin family.	Retinoblastoma 1.	0.547
ENSONIP00000039182	I3JLZ1_ORENI	ENSONIP00000039182	ENSONIP00000009885	annotation not available	SMYLE_N domain-containing protein.	0.470
Haspin	LOC100706117	ENSONIP00000043455	ENSONIP00000056574	Serine/threonine-protein kinase haspin isoform X1.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.550
Haspin	bub1	ENSONIP00000043455	ENSONIP00000073314	Serine/threonine-protein kinase haspin isoform X1.	BUB1 mitotic checkpoint serine/threonine kinase.	0.659
Haspin	bub1b	ENSONIP00000043455	ENSONIP00000015340	Serine/threonine-protein kinase haspin isoform X1.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.566
I3JLZ1_ORENI	ENSONIP00000039182	ENSONIP00000009885	ENSONIP00000039182	SMYLE_N domain-containing protein.	annotation not available	0.470
I3K6J4_ORENI	atm	ENSONIP00000016739	ENSONIP00000006906	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.679
I3K6J4_ORENI	cdc6	ENSONIP00000016739	ENSONIP00000000081	Uncharacterized protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.558
I3K6J4_ORENI	cdt1	ENSONIP00000016739	ENSONIP00000016535	Uncharacterized protein.	Chromatin licensing and DNA replication factor 1.	0.421
I3K6J4_ORENI	xrcc3	ENSONIP00000016739	ENSONIP00000000314	Uncharacterized protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.720
I3KE98_ORENI	LOC100706117	ENSONIP00000055741	ENSONIP00000056574	Zwilch kinetochore protein.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.466
I3KE98_ORENI	Ndc80	ENSONIP00000055741	ENSONIP00000018822	Zwilch kinetochore protein.	NDC80 kinetochore complex component.	0.791
I3KE98_ORENI	bub1	ENSONIP00000055741	ENSONIP00000073314	Zwilch kinetochore protein.	BUB1 mitotic checkpoint serine/threonine kinase.	0.890
I3KE98_ORENI	bub1b	ENSONIP00000055741	ENSONIP00000015340	Zwilch kinetochore protein.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.889