(19 nodes) Megakaryocyte differentiation network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100696076	GATA binding protein 1a. (457 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (616 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (590 aa)
	LOC100698988	E1A binding protein p300 a. (2777 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1834 aa)
	LOC100700725	E1A binding protein p300 b. (2799 aa)
	LOC112841626	Erythroid transcription factor-like isoform X1. (280 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (403 aa)
	zfpm1	Zinc finger protein, FOG family member 1. (1309 aa)
	Gp1bb	Platelet glycoprotein Ib beta chain. (101 aa)
	SP3	Sp3a transcription factor. (671 aa)
	LOC100700918	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	SRF	Serum response factor. (597 aa)
	I3JWF9_ORENI	MADS-box domain-containing protein. (506 aa)
	sh2b3	SH2B adaptor protein 3. (723 aa)
	I3KZ95_ORENI	Glycoprotein IX (platelet). (229 aa)
	ABI1	Abl-interactor 1a. (511 aa)
	LOC100703100	Abl-interactor 1b. (500 aa)
	LOC100707378	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (127 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	LOC100703100	ENSONIP00000029293	ENSONIP00000029405	Abl-interactor 1a.	Abl-interactor 1b.	0.900
Gp1bb	I3KZ95_ORENI	ENSONIP00000066668	ENSONIP00000026442	Platelet glycoprotein Ib beta chain.	Glycoprotein IX (platelet).	0.979
I3KZ95_ORENI	Gp1bb	ENSONIP00000026442	ENSONIP00000066668	Glycoprotein IX (platelet).	Platelet glycoprotein Ib beta chain.	0.979
LOC100696076	LOC100698988	ENSONIP00000038387	ENSONIP00000072968	GATA binding protein 1a.	E1A binding protein p300 a.	0.664
LOC100696076	LOC100700725	ENSONIP00000038387	ENSONIP00000075311	GATA binding protein 1a.	E1A binding protein p300 b.	0.664
LOC100696076	SP3	ENSONIP00000038387	ENSONIP00000010894	GATA binding protein 1a.	Sp3a transcription factor.	0.446
LOC100696076	zfpm1	ENSONIP00000038387	ENSONIP00000054331	GATA binding protein 1a.	Zinc finger protein, FOG family member 1.	0.909
LOC100698988	LOC100696076	ENSONIP00000072968	ENSONIP00000038387	E1A binding protein p300 a.	GATA binding protein 1a.	0.664
LOC100698988	LOC112841626	ENSONIP00000072968	ENSONIP00000080130	E1A binding protein p300 a.	Erythroid transcription factor-like isoform X1.	0.664
LOC100698988	med1	ENSONIP00000072968	ENSONIP00000038435	E1A binding protein p300 a.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.697
LOC100698988	zfpm1	ENSONIP00000072968	ENSONIP00000054331	E1A binding protein p300 a.	Zinc finger protein, FOG family member 1.	0.482
LOC100700725	LOC100696076	ENSONIP00000075311	ENSONIP00000038387	E1A binding protein p300 b.	GATA binding protein 1a.	0.664
LOC100700725	LOC112841626	ENSONIP00000075311	ENSONIP00000080130	E1A binding protein p300 b.	Erythroid transcription factor-like isoform X1.	0.664
LOC100700725	med1	ENSONIP00000075311	ENSONIP00000038435	E1A binding protein p300 b.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.697
LOC100700725	zfpm1	ENSONIP00000075311	ENSONIP00000054331	E1A binding protein p300 b.	Zinc finger protein, FOG family member 1.	0.482
LOC100700918	ptpn11	ENSONIP00000011686	ENSONIP00000071113	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
LOC100703100	ABI1	ENSONIP00000029405	ENSONIP00000029293	Abl-interactor 1b.	Abl-interactor 1a.	0.900
LOC112841626	LOC100698988	ENSONIP00000080130	ENSONIP00000072968	Erythroid transcription factor-like isoform X1.	E1A binding protein p300 a.	0.664
LOC112841626	LOC100700725	ENSONIP00000080130	ENSONIP00000075311	Erythroid transcription factor-like isoform X1.	E1A binding protein p300 b.	0.664
LOC112841626	SP3	ENSONIP00000080130	ENSONIP00000010894	Erythroid transcription factor-like isoform X1.	Sp3a transcription factor.	0.446