(56 nodes) Clathrin-coated vesicle membrane network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100710793	Epsin-1 isoform X1. (892 aa)
	I3ITU2_ORENI	Ig-like domain-containing protein. (212 aa)
	LOC100707170	Receptor expression-enhancing protein. (195 aa)
	LOC100690812	Epsin 3a. (615 aa)
	LOC100710668	Uncharacterized protein. (618 aa)
	atp6v1d	ATPase H+ transporting V1 subunit D. (251 aa)
	tyrp1	Tyrosinase related protein 1. (521 aa)
	LOC100690198	Clathrin interactor 1b. (656 aa)
	LOC100705805	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
	LOC109199535	Sialoadhesin. (263 aa)
	LOC102077443	Ig-like domain-containing protein. (196 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
	dab2	DAB adaptor protein 2. (782 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
	I3K776_ORENI	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1220 aa)
	Atp6ap1	ATPase H+ transporting accessory protein 1a. (468 aa)
	ap3b1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1176 aa)
	epn2	Epsin 2. (576 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (230 aa)
	LOC100695148	Epsin 3b. (597 aa)
	I3KI81_ORENI	ATPase H+ transporting accessory protein 1b. (430 aa)
	LOC100707472	AP complex subunit beta. (953 aa)
	LOC100707016	Clathrin interactor 1a. (629 aa)
	VAMP3	Vesicle associated membrane protein 3. (121 aa)
	LOC100705449	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
	I3KXX1_ORENI	Solute carrier family 18 member A3. (499 aa)
	LOC102077656	Solute carrier family 18 member 3a. (516 aa)
	atp6v1h	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (486 aa)
	cltb	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (224 aa)
	LOC100698164	NECAP endocytosis associated 1. (278 aa)
	necap2	NECAP endocytosis associated 2. (255 aa)
	LOC100694167	Epsin 1. (650 aa)
	ap1b1	AP complex subunit beta. (1001 aa)
	ENSONIP00000044679	annotation not available (146 aa)
	Clhc1	Clathrin heavy chain linker domain-containing protein 1 isoform X1. (403 aa)
	AP3B2	AP-3 complex subunit beta. (1230 aa)
	LOC100694377	AP-1 complex subunit gamma. (789 aa)
	ap1g1	AP-1 complex subunit gamma. (823 aa)
	LOC102078421	Ig-like domain-containing protein. (274 aa)
	LOC100711224	Tyrosinase-related protein 1b. (540 aa)
	LOC100691387	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1642 aa)
	LOC100700052	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (965 aa)
	cltc	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (383 aa)
	LOC100696294	Receptor expression-enhancing protein. (232 aa)
	synrg	Synergin, gamma. (1477 aa)
	aftph	Aftiphilin isoform X2. (666 aa)
	LOC100696314	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (994 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
	atp6v1f	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	ENSONIP00000070861	Uncharacterized protein LOC106096553 isoform X1. (298 aa)
	atp6v0b	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (211 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	LOC100711908	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1705 aa)
	atp6v1a	ATPase H+ transporting V1 subunit A. (618 aa)
	I3K0A7_ORENI	DENN/MADD domain containing 1A. (958 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP3B2	Clhc1	ENSONIP00000048400	ENSONIP00000044814	AP-3 complex subunit beta.	Clathrin heavy chain linker domain-containing protein 1 isoform X1.	0.570
AP3B2	LOC100691387	ENSONIP00000048400	ENSONIP00000058722	AP-3 complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.612
AP3B2	LOC100694377	ENSONIP00000048400	ENSONIP00000048943	AP-3 complex subunit beta.	AP-1 complex subunit gamma.	0.894
AP3B2	LOC100698164	ENSONIP00000048400	ENSONIP00000035181	AP-3 complex subunit beta.	NECAP endocytosis associated 1.	0.519
AP3B2	LOC100700052	ENSONIP00000048400	ENSONIP00000061455	AP-3 complex subunit beta.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.852
AP3B2	LOC100707472	ENSONIP00000048400	ENSONIP00000021924	AP-3 complex subunit beta.	AP complex subunit beta.	0.735
AP3B2	LOC100711908	ENSONIP00000048400	ENSONIP00000077415	AP-3 complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.612
AP3B2	VAMP3	ENSONIP00000048400	ENSONIP00000024327	AP-3 complex subunit beta.	Vesicle associated membrane protein 3.	0.467
AP3B2	ap1b1	ENSONIP00000048400	ENSONIP00000042829	AP-3 complex subunit beta.	AP complex subunit beta.	0.735
AP3B2	ap1g1	ENSONIP00000048400	ENSONIP00000054543	AP-3 complex subunit beta.	AP-1 complex subunit gamma.	0.894
AP3B2	ap2m1	ENSONIP00000048400	ENSONIP00000013073	AP-3 complex subunit beta.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.511
AP3B2	ap3b1	ENSONIP00000048400	ENSONIP00000019460	AP-3 complex subunit beta.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.902
AP3B2	clta	ENSONIP00000048400	ENSONIP00000020435	AP-3 complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.567
AP3B2	cltb	ENSONIP00000048400	ENSONIP00000034360	AP-3 complex subunit beta.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.567
AP3B2	cltc	ENSONIP00000048400	ENSONIP00000063162	AP-3 complex subunit beta.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.612
AP3B2	necap2	ENSONIP00000048400	ENSONIP00000039008	AP-3 complex subunit beta.	NECAP endocytosis associated 2.	0.527
ATP6V0C	Atp6ap1	ENSONIP00000072138	ENSONIP00000018645	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATPase H+ transporting accessory protein 1a.	0.927
ATP6V0C	I3KI81_ORENI	ENSONIP00000072138	ENSONIP00000020827	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATPase H+ transporting accessory protein 1b.	0.927
ATP6V0C	LOC100700052	ENSONIP00000072138	ENSONIP00000061455	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.505
ATP6V0C	LOC100705449	ENSONIP00000072138	ENSONIP00000024425	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.900