(19 nodes) Thyroid gland development network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100710579	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1213 aa)
	LOC100701954	Paired box 8. (466 aa)
	LOC100699141	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1248 aa)
	Hesx1	Homeobox domain-containing protein. (138 aa)
	hhex	Homeobox domain-containing protein. (289 aa)
	pax5	Paired box 5. (425 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (442 aa)
	SRF	Serum response factor. (597 aa)
	I3JWF9_ORENI	MADS-box domain-containing protein. (506 aa)
	LOC100706592	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	LOC100691488	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	pax2	Paired box 2b. (402 aa)
	nkx2-5	NK2 homeobox 5. (319 aa)
	LOC109194259	T-cell acute lymphocytic leukemia 1. (447 aa)
	ENSONIP00000035341	T-cell acute lymphocytic leukemia protein 1 homolog. (100 aa)
	edn1	Endothelin 1. (202 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
	hand2	Heart and neural crest derivatives expressed 2. (245 aa)
	LOC100697440	Paired box 2a. (489 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3JWF9_ORENI	nkx2-5	ENSONIP00000013204	ENSONIP00000022291	MADS-box domain-containing protein.	NK2 homeobox 5.	0.551
LOC100691488	edn1	ENSONIP00000016574	ENSONIP00000041174	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.571
LOC100691488	hand2	ENSONIP00000016574	ENSONIP00000068818	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.484
LOC100691488	nkx2-5	ENSONIP00000016574	ENSONIP00000022291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 5.	0.450
LOC100699141	LOC100710579	ENSONIP00000002097	ENSONIP00000060717	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.901
LOC100699141	jag1	ENSONIP00000002097	ENSONIP00000047710	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.902
LOC100706592	edn1	ENSONIP00000014756	ENSONIP00000041174	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.996
LOC100706592	ednra	ENSONIP00000014756	ENSONIP00000012586	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC100710579	LOC100699141	ENSONIP00000060717	ENSONIP00000002097	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.901
LOC100710579	jag1	ENSONIP00000060717	ENSONIP00000047710	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
SRF	nkx2-5	ENSONIP00000012780	ENSONIP00000022291	Serum response factor.	NK2 homeobox 5.	0.551
edn1	LOC100691488	ENSONIP00000041174	ENSONIP00000016574	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
edn1	LOC100706592	ENSONIP00000041174	ENSONIP00000014756	Endothelin 1.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.996
edn1	ednra	ENSONIP00000041174	ENSONIP00000012586	Endothelin 1.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.998
edn1	hand2	ENSONIP00000041174	ENSONIP00000068818	Endothelin 1.	Heart and neural crest derivatives expressed 2.	0.709
edn1	jag1	ENSONIP00000041174	ENSONIP00000047710	Endothelin 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.645
ednra	LOC100706592	ENSONIP00000012586	ENSONIP00000014756	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.902
ednra	edn1	ENSONIP00000012586	ENSONIP00000041174	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
hand2	LOC100691488	ENSONIP00000068818	ENSONIP00000016574	Heart and neural crest derivatives expressed 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.484
hand2	edn1	ENSONIP00000068818	ENSONIP00000041174	Heart and neural crest derivatives expressed 2.	Endothelin 1.	0.709