(19 nodes) Thyroid gland development network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100697440	Paired box 2a. (489 aa)
	LOC100701954	Paired box 8. (466 aa)
	LOC100699141	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1248 aa)
	Hesx1	Homeobox domain-containing protein. (138 aa)
	hhex	Homeobox domain-containing protein. (289 aa)
	pax5	Paired box 5. (425 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (442 aa)
	SRF	Serum response factor. (597 aa)
	I3JWF9_ORENI	MADS-box domain-containing protein. (506 aa)
	LOC100706592	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	LOC100691488	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	pax2	Paired box 2b. (402 aa)
	nkx2-5	NK2 homeobox 5. (319 aa)
	LOC109194259	T-cell acute lymphocytic leukemia 1. (447 aa)
	ENSONIP00000035341	T-cell acute lymphocytic leukemia protein 1 homolog. (100 aa)
	edn1	Endothelin 1. (202 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
	LOC100710579	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1213 aa)
	hand2	Heart and neural crest derivatives expressed 2. (245 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3JWF9_ORENI	nkx2-5	ENSONIP00000013204	ENSONIP00000022291	MADS-box domain-containing protein.	NK2 homeobox 5.	0.551
LOC100691488	edn1	ENSONIP00000016574	ENSONIP00000041174	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.571
LOC100691488	hand2	ENSONIP00000016574	ENSONIP00000068818	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.484
LOC100691488	nkx2-5	ENSONIP00000016574	ENSONIP00000022291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 5.	0.450
LOC100699141	LOC100710579	ENSONIP00000002097	ENSONIP00000060717	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.901
LOC100699141	jag1	ENSONIP00000002097	ENSONIP00000047710	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.902
LOC100706592	edn1	ENSONIP00000014756	ENSONIP00000041174	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.996
LOC100706592	ednra	ENSONIP00000014756	ENSONIP00000012586	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC100710579	LOC100699141	ENSONIP00000060717	ENSONIP00000002097	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.901
LOC100710579	jag1	ENSONIP00000060717	ENSONIP00000047710	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.903
SRF	nkx2-5	ENSONIP00000012780	ENSONIP00000022291	Serum response factor.	NK2 homeobox 5.	0.551
edn1	LOC100691488	ENSONIP00000041174	ENSONIP00000016574	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.571
edn1	LOC100706592	ENSONIP00000041174	ENSONIP00000014756	Endothelin 1.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.996
edn1	ednra	ENSONIP00000041174	ENSONIP00000012586	Endothelin 1.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.998
edn1	hand2	ENSONIP00000041174	ENSONIP00000068818	Endothelin 1.	Heart and neural crest derivatives expressed 2.	0.709
edn1	jag1	ENSONIP00000041174	ENSONIP00000047710	Endothelin 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.645
ednra	LOC100706592	ENSONIP00000012586	ENSONIP00000014756	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.902
ednra	edn1	ENSONIP00000012586	ENSONIP00000041174	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
hand2	LOC100691488	ENSONIP00000068818	ENSONIP00000016574	Heart and neural crest derivatives expressed 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.484
hand2	edn1	ENSONIP00000068818	ENSONIP00000041174	Heart and neural crest derivatives expressed 2.	Endothelin 1.	0.709