(61 nodes) Pancreas development network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
	LOC100699623	IKAROS family zinc finger 5. (423 aa)
	bmp2	Bone morphogenetic protein 2b. (418 aa)
	ISL2	ISL LIM homeobox 2b. (364 aa)
	LOC100705868	Uncharacterized protein. (431 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (977 aa)
	yap1	Yes-associated protein 1. (455 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (315 aa)
	LOC100695684	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (488 aa)
	LOC100703553	Notch receptor 1a. (2480 aa)
	LOC100710660	T-box transcription factor Ta. (463 aa)
	LOC100709626	Wolfram syndrome 1a (wolframin). (1062 aa)
	notch1	Notch receptor 1b. (2519 aa)
	hnf1a	HNF1 homeobox a. (559 aa)
	LOC100704607	Paired box 4. (407 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (411 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (515 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1102 aa)
	hnf1b	HNF1 homeobox Ba. (576 aa)
	Sart3	Spliceosome associated factor 3, U4/U6 recycling protein. (997 aa)
	LOC100700683	ISL LIM homeobox 1. (351 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (766 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	arx	Aristaless related homeobox a. (484 aa)
	LOC100705166	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (414 aa)
	ISL2-2	ISL LIM homeobox 2a. (363 aa)
	LOC100692689	IKAROS family zinc finger 5. (417 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (265 aa)
	ptf1a	Pancreas associated transcription factor 1a. (273 aa)
	LOC100704156	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	hhex	Homeobox domain-containing protein. (289 aa)
	LOC100706164	Zgc:153993. (203 aa)
	LOC100706476	Homeobox domain-containing protein. (248 aa)
	utp25	UTP25 small subunit processor component. (648 aa)
	LOC100706722	Achaete-scute family bHLH transcription factor 1b. (203 aa)
	LOC100710315	Insulinoma-associated 1b. (488 aa)
	insm1	Insulinoma-associated 1a. (447 aa)
	ENSONIP00000032417	Uncharacterized protein LOC100702023 isoform X1. (699 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (774 aa)
	Pax6	Paired box 6b. (445 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1506 aa)
	MYO1D	Myosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1011 aa)
	ENSONIP00000038958	RNA binding motif protein 4.2. (230 aa)
	I3K258_ORENI	Neuron navigator 3. (427 aa)
	ENSONIP00000040127	annotation not available (89 aa)
	LOC100704302	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (411 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (582 aa)
	LOC100690824	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa)
	LOC102079407	Furin-like protease kpc-1 isoform X1. (806 aa)
	nkx6-1	NK6 homeobox 1. (320 aa)
	neurod1	Neurogenic differentiation factor. (471 aa)
	Nkx6-2	NK6 homeobox 2. (89 aa)
	I3JN05_ORENI	NK2 homeobox 2a. (254 aa)
	ENSONIP00000058376	annotation not available (135 aa)
	Fgfr2	Fibroblast growth factor receptor. (865 aa)
	I3KAU3_ORENI	Insulin-like growth factor 2b. (217 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (602 aa)
	rfx6	Regulatory factor X, 6. (959 aa)
	LOC100695663	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000038958	rnpc3	ENSONIP00000038958	ENSONIP00000071546	RNA binding motif protein 4.2.	RNA-binding region (RNP1, RRM) containing 3.	0.441
ENSONIP00000038958	srp54	ENSONIP00000038958	ENSONIP00000014814	RNA binding motif protein 4.2.	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.	0.456
ENSONIP00000040127	LOC102079407	ENSONIP00000040127	ENSONIP00000052844	annotation not available	Furin-like protease kpc-1 isoform X1.	0.511
ENSONIP00000040127	pcsk1	ENSONIP00000040127	ENSONIP00000034968	annotation not available	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.511
ENSONIP00000040127	pdx1	ENSONIP00000040127	ENSONIP00000017773	annotation not available	Pancreatic and duodenal homeobox 1.	0.580
ENSONIP00000040127	ptf1a	ENSONIP00000040127	ENSONIP00000021410	annotation not available	Pancreas associated transcription factor 1a.	0.424
ENSONIP00000040127	rfx6	ENSONIP00000040127	ENSONIP00000075378	annotation not available	Regulatory factor X, 6.	0.470
ENSONIP00000058376	suv39h1	ENSONIP00000058376	ENSONIP00000014663	annotation not available	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.759
Fgfr2	LOC100704156	ENSONIP00000060910	ENSONIP00000022171	Fibroblast growth factor receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.671
Fgfr2	ins	ENSONIP00000060910	ENSONIP00000000431	Fibroblast growth factor receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.668
I3JN05_ORENI	LOC100704156	ENSONIP00000057746	ENSONIP00000022171	NK2 homeobox 2a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.424
I3JN05_ORENI	neurod1	ENSONIP00000057746	ENSONIP00000057365	NK2 homeobox 2a.	Neurogenic differentiation factor.	0.486
I3JN05_ORENI	shh	ENSONIP00000057746	ENSONIP00000007484	NK2 homeobox 2a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.424
ISL2	LOC100706722	ENSONIP00000003151	ENSONIP00000025745	ISL LIM homeobox 2b.	Achaete-scute family bHLH transcription factor 1b.	0.407
ISL2	ptf1a	ENSONIP00000003151	ENSONIP00000021410	ISL LIM homeobox 2b.	Pancreas associated transcription factor 1a.	0.425
ISL2-2	LOC100706722	ENSONIP00000019199	ENSONIP00000025745	ISL LIM homeobox 2a.	Achaete-scute family bHLH transcription factor 1b.	0.407
ISL2-2	ptf1a	ENSONIP00000019199	ENSONIP00000021410	ISL LIM homeobox 2a.	Pancreas associated transcription factor 1a.	0.402
LOC100690824	LOC100695663	ENSONIP00000052284	ENSONIP00000080278	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC100690824	smo	ENSONIP00000052284	ENSONIP00000014674	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.470
LOC100695663	LOC100690824	ENSONIP00000080278	ENSONIP00000052284	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901