(33 nodes) Heterochromatin assembly network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (768 aa)
	LOC100702285	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db. (572 aa)
	Hmga2	Uncharacterized protein. (132 aa)
	znfx1	Zinc finger, NFX1-type containing 1. (1953 aa)
	LOC100702714	Uncharacterized protein. (236 aa)
	LOC100698109	Methyl-CpG binding domain protein 3. (239 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (712 aa)
	I3JW57_ORENI	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1892 aa)
	ppm1d	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da. (557 aa)
	fam172a	Family with sequence similarity 172 member A. (435 aa)
	LOC100708236	Methyl-CpG binding domain protein 2. (266 aa)
	hells	Helicase, lymphoid specific. (854 aa)
	I3K885_ORENI	Uncharacterized protein; Belongs to the intermediate filament family. (659 aa)
	spty2d1	SPT2 chromatin protein domain containing 1. (703 aa)
	LOC100696323	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1475 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (539 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (763 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1510 aa)
	mecp2	Methyl CpG binding protein 2. (1076 aa)
	rif1	Replication timing regulatory factor 1. (2388 aa)
	dot1l	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1610 aa)
	smchd1	Structural maintenance of chromosomes flexible hinge domain containing 1. (1985 aa)
	sirt6	Sirtuin 6. (356 aa)
	LOC100691959	Lamin L3; Belongs to the intermediate filament family. (644 aa)
	bahd1	Bromo adjacent homology domain-containing 1 protein. (853 aa)
	I3K9B0_ORENI	GFA domain-containing protein. (153 aa)
	hat1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (416 aa)
	LOC102080314	Bromo adjacent homology domain-containing 1 protein. (886 aa)
	lmnb2	Lamin B2; Belongs to the intermediate filament family. (616 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
	LOC100701661	Methyl-CpG-binding domain protein 3 isoform X1. (297 aa)
	lmna	Lamin A; Belongs to the intermediate filament family. (658 aa)
	rb1	Retinoblastoma 1. (919 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EZH1	LOC100696323	ENSONIP00000001530	ENSONIP00000021143	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.740
EZH1	dnmt1	ENSONIP00000001530	ENSONIP00000029113	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.877
EZH1	dot1l	ENSONIP00000001530	ENSONIP00000036677	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.423
EZH1	hells	ENSONIP00000001530	ENSONIP00000016561	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Helicase, lymphoid specific.	0.448
EZH1	sirt1	ENSONIP00000001530	ENSONIP00000012918	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Deacetylase sirtuin-type domain-containing protein.	0.593
I3JW57_ORENI	sirt1	ENSONIP00000013102	ENSONIP00000012918	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	Deacetylase sirtuin-type domain-containing protein.	0.585
I3JW57_ORENI	znfx1	ENSONIP00000013102	ENSONIP00000008592	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	Zinc finger, NFX1-type containing 1.	0.588
LOC100691959	lmna	ENSONIP00000048422	ENSONIP00000066063	Lamin L3; Belongs to the intermediate filament family.	Lamin A; Belongs to the intermediate filament family.	0.909
LOC100691959	lmnb2	ENSONIP00000048422	ENSONIP00000062480	Lamin L3; Belongs to the intermediate filament family.	Lamin B2; Belongs to the intermediate filament family.	0.900
LOC100696323	EZH1	ENSONIP00000021143	ENSONIP00000001530	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.740
LOC100696323	LOC100702714	ENSONIP00000021143	ENSONIP00000010712	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.673
LOC100696323	dnmt1	ENSONIP00000021143	ENSONIP00000029113	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.995
LOC100696323	ezh2	ENSONIP00000021143	ENSONIP00000022257	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.740
LOC100696323	hells	ENSONIP00000021143	ENSONIP00000016561	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Helicase, lymphoid specific.	0.486
LOC100696323	mecp2	ENSONIP00000021143	ENSONIP00000029287	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl CpG binding protein 2.	0.623
LOC100698109	dnmt1	ENSONIP00000012845	ENSONIP00000029113	Methyl-CpG binding domain protein 3.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.516
LOC100701661	dnmt1	ENSONIP00000065913	ENSONIP00000029113	Methyl-CpG-binding domain protein 3 isoform X1.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.531
LOC100702285	ppm1d	ENSONIP00000002398	ENSONIP00000013159	Protein phosphatase, Mg2+/Mn2+ dependent, 1Db.	Protein phosphatase, Mg2+/Mn2+ dependent, 1Da.	0.903
LOC100702714	LOC100696323	ENSONIP00000010712	ENSONIP00000021143	Uncharacterized protein.	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.673
LOC100702714	dnmt1	ENSONIP00000010712	ENSONIP00000029113	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.858