(23 nodes) Cellular response to heat network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1064 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (2364 aa)
	st8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (335 aa)
	Nf1	Neurofibromin 1b. (2742 aa)
	LOC100694797	Translocated promoter region a, nuclear basket protein. (2505 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (673 aa)
	mki67	Marker of proliferation Ki-67. (1874 aa)
	IER5L	Immediate early response 5 like. (297 aa)
	LOC100692001	Transcriptional and immune response regulator a. (100 aa)
	hikeshi	Heat shock protein nuclear import factor hikeshi. (198 aa)
	Hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (752 aa)
	tfec	Transcription factor EC. (481 aa)
	daxx	Death-domain associated protein. (744 aa)
	LOC100689869	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (271 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (509 aa)
	LOC100706512	Alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8F). (352 aa)
	LOC100701982	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (770 aa)
	ENSONIP00000071274	annotation not available (59 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)
	ENSONIP00000075873	Heat shock factor binding protein 1a. (66 aa)
	bag3	BCL2 associated athanogene 3. (543 aa)
	IER5L-2	Immediate early response 5-like. (281 aa)
	LOC100704829	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (270 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	Hsp90ab1	ENSONIP00000021077	ENSONIP00000032806	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.773
CLPB	LOC100701982	ENSONIP00000021077	ENSONIP00000070041	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.773
CLPB	hikeshi	ENSONIP00000021077	ENSONIP00000026136	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Heat shock protein nuclear import factor hikeshi.	0.634
ENSONIP00000071274	Hsp90ab1	ENSONIP00000071274	ENSONIP00000032806	annotation not available	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.457
ENSONIP00000071274	LOC100701982	ENSONIP00000071274	ENSONIP00000070041	annotation not available	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.457
ENSONIP00000075873	Hsp90ab1	ENSONIP00000075873	ENSONIP00000032806	Heat shock factor binding protein 1a.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.624
ENSONIP00000075873	LOC100701982	ENSONIP00000075873	ENSONIP00000070041	Heat shock factor binding protein 1a.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.624
Hsp90ab1	CLPB	ENSONIP00000032806	ENSONIP00000021077	Heat shock protein 90, alpha (cytosolic), class B member 1.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.773
Hsp90ab1	ENSONIP00000071274	ENSONIP00000032806	ENSONIP00000071274	Heat shock protein 90, alpha (cytosolic), class B member 1.	annotation not available	0.457
Hsp90ab1	ENSONIP00000075873	ENSONIP00000032806	ENSONIP00000075873	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock factor binding protein 1a.	0.624
Hsp90ab1	LOC100689869	ENSONIP00000032806	ENSONIP00000046559	Heat shock protein 90, alpha (cytosolic), class B member 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	0.596
Hsp90ab1	LOC100701982	ENSONIP00000032806	ENSONIP00000070041	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.946
Hsp90ab1	LOC100704829	ENSONIP00000032806	ENSONIP00000078688	Heat shock protein 90, alpha (cytosolic), class B member 1.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.596
Hsp90ab1	bag3	ENSONIP00000032806	ENSONIP00000077530	Heat shock protein 90, alpha (cytosolic), class B member 1.	BCL2 associated athanogene 3.	0.418
LOC100689869	Hsp90ab1	ENSONIP00000046559	ENSONIP00000032806	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.596
LOC100689869	LOC100701982	ENSONIP00000046559	ENSONIP00000070041	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.596
LOC100689869	LOC100704829	ENSONIP00000046559	ENSONIP00000078688	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.901
LOC100689869	bag3	ENSONIP00000046559	ENSONIP00000077530	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	BCL2 associated athanogene 3.	0.440
LOC100694797	sumo1	ENSONIP00000020894	ENSONIP00000072692	Translocated promoter region a, nuclear basket protein.	Small ubiquitin-related modifier.	0.516
LOC100701982	CLPB	ENSONIP00000070041	ENSONIP00000021077	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	ClpB homolog, mitochondrial AAA ATPase chaperonin.	0.773