(39 nodes) Embryonic hemopoiesis network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	atf4	Activating transcription factor 4a. (726 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (385 aa)
	hdac9	Histone deacetylase 9b. (623 aa)
	yap1	Yes-associated protein 1. (455 aa)
	tbx20	T-box transcription factor 20. (440 aa)
	I3JHS7_ORENI	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (196 aa)
	hhex	Homeobox domain-containing protein. (289 aa)
	ccdc134	Si:dkey-167k11.5. (229 aa)
	trim33	Tripartite motif containing 33. (1216 aa)
	ism1	Isthmin 1. (499 aa)
	chrd	Chordin; Belongs to the chordin family. (949 aa)
	I3K114_ORENI	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
	LOC100712573	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (637 aa)
	ncoa2	Nuclear receptor coactivator 2. (1538 aa)
	sh2b3	SH2B adaptor protein 3. (723 aa)
	LOC100698057	Nuclear receptor coactivator. (1528 aa)
	LOC106098551	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (614 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (538 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (288 aa)
	LOC100698523	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa)
	LOC109194259	T-cell acute lymphocytic leukemia 1. (447 aa)
	Bmi1	Bmi1 polycomb ring finger oncogene 1a. (335 aa)
	ENSONIP00000035341	T-cell acute lymphocytic leukemia protein 1 homolog. (100 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1506 aa)
	LOC100696076	GATA binding protein 1a. (457 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1834 aa)
	etnppl	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (508 aa)
	Prkca	Protein kinase C, alpha, a. (674 aa)
	tll1	Metalloendopeptidase. (1068 aa)
	nop10	NOP10 ribonucleoprotein homolog (yeast). (64 aa)
	I3K0T5_ORENI	Metalloendopeptidase. (988 aa)
	I3K6L9_ORENI	Myc target 1a. (199 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (161 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC100703205	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (842 aa)
	LOC100697245	5-aminolevulinate synthase. (591 aa)
	LOC100691570	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (505 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (567 aa)
	LOC112841626	Erythroid transcription factor-like isoform X1. (280 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000035341	LOC100696076	ENSONIP00000035341	ENSONIP00000038387	T-cell acute lymphocytic leukemia protein 1 homolog.	GATA binding protein 1a.	0.764
ENSONIP00000035341	LOC112841626	ENSONIP00000035341	ENSONIP00000080130	T-cell acute lymphocytic leukemia protein 1 homolog.	Erythroid transcription factor-like isoform X1.	0.764
ENSONIP00000035341	lmo2	ENSONIP00000035341	ENSONIP00000051247	T-cell acute lymphocytic leukemia protein 1 homolog.	LIM domain only 2 (rhombotin-like 1).	0.965
I3K0T5_ORENI	chrd	ENSONIP00000049943	ENSONIP00000013587	Metalloendopeptidase.	Chordin; Belongs to the chordin family.	0.847
I3K0T5_ORENI	yap1	ENSONIP00000049943	ENSONIP00000007219	Metalloendopeptidase.	Yes-associated protein 1.	0.444
I3K114_ORENI	LOC100697245	ENSONIP00000014809	ENSONIP00000059787	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	5-aminolevulinate synthase.	0.581
I3K114_ORENI	slc40a1	ENSONIP00000014809	ENSONIP00000074915	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.465
LOC100696076	ENSONIP00000035341	ENSONIP00000038387	ENSONIP00000035341	GATA binding protein 1a.	T-cell acute lymphocytic leukemia protein 1 homolog.	0.764
LOC100696076	LOC100697245	ENSONIP00000038387	ENSONIP00000059787	GATA binding protein 1a.	5-aminolevulinate synthase.	0.465
LOC100696076	LOC109194259	ENSONIP00000038387	ENSONIP00000034543	GATA binding protein 1a.	T-cell acute lymphocytic leukemia 1.	0.764
LOC100696076	lmo2	ENSONIP00000038387	ENSONIP00000051247	GATA binding protein 1a.	LIM domain only 2 (rhombotin-like 1).	0.941
LOC100697245	I3K114_ORENI	ENSONIP00000059787	ENSONIP00000014809	5-aminolevulinate synthase.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.581
LOC100697245	LOC100696076	ENSONIP00000059787	ENSONIP00000038387	5-aminolevulinate synthase.	GATA binding protein 1a.	0.465
LOC100697245	LOC112841626	ENSONIP00000059787	ENSONIP00000080130	5-aminolevulinate synthase.	Erythroid transcription factor-like isoform X1.	0.465
LOC100698057	med1	ENSONIP00000018781	ENSONIP00000038435	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.688
LOC100698523	Prkca	ENSONIP00000033597	ENSONIP00000044922	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C, alpha, a.	0.900
LOC100703205	PRKCB	ENSONIP00000057072	ENSONIP00000052205	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.900
LOC106098551	TGFBR2	ENSONIP00000020326	ENSONIP00000024765	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.903
LOC109194259	LOC100696076	ENSONIP00000034543	ENSONIP00000038387	T-cell acute lymphocytic leukemia 1.	GATA binding protein 1a.	0.764
LOC109194259	LOC112841626	ENSONIP00000034543	ENSONIP00000080130	T-cell acute lymphocytic leukemia 1.	Erythroid transcription factor-like isoform X1.	0.764