(87 nodes) Endocrine system development network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100705166	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (414 aa)
	Med12	Mediator complex subunit 12. (2107 aa)
	LOC100708190	Homeobox domain-containing protein. (231 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1588 aa)
	six3	SIX homeobox 3a. (294 aa)
	LOC100703385	ATP-binding cassette, sub-family D (ALD), member 1. (757 aa)
	ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
	LOC100701954	Paired box 8. (466 aa)
	I3J0L4_ORENI	T-box transcription factor 2a. (621 aa)
	LOC100705868	Uncharacterized protein. (431 aa)
	Hesx1	Homeobox domain-containing protein. (138 aa)
	gsx1	GS homeobox 1. (243 aa)
	I3JDN0_ORENI	WT1 transcription factor b. (422 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (415 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (315 aa)
	nr0b1	NR LBD domain-containing protein. (294 aa)
	LOC100703294	Uncharacterized protein. (677 aa)
	hhex	Homeobox domain-containing protein. (289 aa)
	LOC100711859	Retinal homeobox gene 3. (315 aa)
	pax5	Paired box 5. (425 aa)
	LOC100698617	Homeobox protein. (295 aa)
	Armc5	Armadillo repeat containing 5. (1208 aa)
	gcm2	Glial cells missing transcription factor 2. (465 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (442 aa)
	SRF	Serum response factor. (597 aa)
	I3JWF9_ORENI	MADS-box domain-containing protein. (506 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (270 aa)
	LOC100694473	WT1 transcription factor a. (476 aa)
	LOC100704607	Paired box 4. (407 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	LOC100706592	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1102 aa)
	hnf1b	HNF1 homeobox Ba. (576 aa)
	LOC100691488	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (766 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (255 aa)
	arx	Aristaless related homeobox a. (484 aa)
	LOC100699141	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1248 aa)
	Nf1	Neurofibromin 1b. (2742 aa)
	LOC100708243	SIX homeobox 3b. (279 aa)
	pax2	Paired box 2b. (402 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (265 aa)
	LOC100708634	Apolipoprotein A-Ib. (263 aa)
	LOC100704156	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
	nkx2-5	NK2 homeobox 5. (319 aa)
	LOC100706164	Zgc:153993. (203 aa)
	LOC100706476	Homeobox domain-containing protein. (248 aa)
	GATA2	GATA binding protein 2. (455 aa)
	six6	SIX homeobox 6a. (245 aa)
	LOC100705840	GATA binding protein 2a. (458 aa)
	LOC100706722	Achaete-scute family bHLH transcription factor 1b. (203 aa)
	Cyp1c1	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (570 aa)
	I3KYY8_ORENI	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (525 aa)
	LOC100710315	Insulinoma-associated 1b. (488 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (188 aa)
	insm1	Insulinoma-associated 1a. (447 aa)
	nkx6-1	NK6 homeobox 1. (320 aa)
	ENSONIP00000032417	Uncharacterized protein LOC100702023 isoform X1. (699 aa)
	LOC100692334	Dickkopf WNT signaling pathway inhibitor 3a. (292 aa)
	LOC109194259	T-cell acute lymphocytic leukemia 1. (447 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (774 aa)
	ENSONIP00000035341	T-cell acute lymphocytic leukemia protein 1 homolog. (100 aa)
	Pax6	Paired box 6b. (445 aa)
	TBX2	T-box transcription factor 2. (739 aa)
	ENSONIP00000040127	annotation not available (89 aa)
	ENSONIP00000040932	T-box transcription factor TBX1-A. (290 aa)
	edn1	Endothelin 1. (202 aa)
	ENSONIP00000043344	annotation not available (98 aa)
	LOC100704302	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (411 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (582 aa)
	I3KNU7_ORENI	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (262 aa)
	LOC100690824	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa)
	LOC102079407	Furin-like protease kpc-1 isoform X1. (806 aa)
	neurod1	Neurogenic differentiation factor. (471 aa)
	Nkx6-2	NK6 homeobox 2. (89 aa)
	I3JN05_ORENI	NK2 homeobox 2a. (254 aa)
	LOC100710579	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1213 aa)
	cyp1b1	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa)
	hand2	Heart and neural crest derivatives expressed 2. (245 aa)
	bsx	Brain-specific homeobox. (225 aa)
	rfx6	Regulatory factor X, 6. (959 aa)
	LOC100711751	SIX homeobox 7. (260 aa)
	I3KFM8_ORENI	T-box transcription factor 1. (434 aa)
	LOC100695663	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC100697440	Paired box 2a. (489 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000035341	GATA2	ENSONIP00000035341	ENSONIP00000023968	T-cell acute lymphocytic leukemia protein 1 homolog.	GATA binding protein 2.	0.688
ENSONIP00000035341	LOC100705840	ENSONIP00000035341	ENSONIP00000025629	T-cell acute lymphocytic leukemia protein 1 homolog.	GATA binding protein 2a.	0.688
ENSONIP00000040127	LOC102079407	ENSONIP00000040127	ENSONIP00000052844	annotation not available	Furin-like protease kpc-1 isoform X1.	0.511
ENSONIP00000040127	pcsk1	ENSONIP00000040127	ENSONIP00000034968	annotation not available	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.511
ENSONIP00000040127	pdx1	ENSONIP00000040127	ENSONIP00000017773	annotation not available	Pancreatic and duodenal homeobox 1.	0.580
ENSONIP00000040127	rfx6	ENSONIP00000040127	ENSONIP00000075378	annotation not available	Regulatory factor X, 6.	0.470
ENSONIP00000040932	nkx2-5	ENSONIP00000040932	ENSONIP00000022291	T-box transcription factor TBX1-A.	NK2 homeobox 5.	0.475
ENSONIP00000043344	LOC102079407	ENSONIP00000043344	ENSONIP00000052844	annotation not available	Furin-like protease kpc-1 isoform X1.	0.477
ENSONIP00000043344	pcsk1	ENSONIP00000043344	ENSONIP00000034968	annotation not available	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.477
GATA2	ENSONIP00000035341	ENSONIP00000023968	ENSONIP00000035341	GATA binding protein 2.	T-cell acute lymphocytic leukemia protein 1 homolog.	0.688
GATA2	I3J0L4_ORENI	ENSONIP00000023968	ENSONIP00000002404	GATA binding protein 2.	T-box transcription factor 2a.	0.507
GATA2	LOC109194259	ENSONIP00000023968	ENSONIP00000034543	GATA binding protein 2.	T-cell acute lymphocytic leukemia 1.	0.688
GATA2	hand2	ENSONIP00000023968	ENSONIP00000068818	GATA binding protein 2.	Heart and neural crest derivatives expressed 2.	0.411
I3J0L4_ORENI	GATA2	ENSONIP00000002404	ENSONIP00000023968	T-box transcription factor 2a.	GATA binding protein 2.	0.507
I3J0L4_ORENI	nkx2-5	ENSONIP00000002404	ENSONIP00000022291	T-box transcription factor 2a.	NK2 homeobox 5.	0.517
I3JDN0_ORENI	nr0b1	ENSONIP00000006970	ENSONIP00000008414	WT1 transcription factor b.	NR LBD domain-containing protein.	0.472
I3JN05_ORENI	LOC100704156	ENSONIP00000057746	ENSONIP00000022171	NK2 homeobox 2a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.424
I3JN05_ORENI	neurod1	ENSONIP00000057746	ENSONIP00000057365	NK2 homeobox 2a.	Neurogenic differentiation factor.	0.486
I3JN05_ORENI	shh	ENSONIP00000057746	ENSONIP00000007484	NK2 homeobox 2a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.424
I3JWF9_ORENI	nkx2-5	ENSONIP00000013204	ENSONIP00000022291	MADS-box domain-containing protein.	NK2 homeobox 5.	0.551