(32 nodes) CD4-positive, alpha-beta T cell activation network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tmem98	Transmembrane protein 98. (224 aa)
	gpr183	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	cd83	Ig-like domain-containing protein. (225 aa)
	LOC102077017	Uncharacterized protein. (220 aa)
	sash3	SAM and SH3 domain containing 3. (398 aa)
	LOC100709775	Ring finger and CCCH-type domains 2. (1152 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (379 aa)
	LOC100690478	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	card11	Caspase recruitment domain family, member 11. (1162 aa)
	I3JPD5_ORENI	Fibronectin type-III domain-containing protein. (341 aa)
	LOC100697163	E3 ubiquitin-protein ligase. (888 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2537 aa)
	Armc5	Armadillo repeat containing 5. (1208 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1105 aa)
	LOC100696844	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (482 aa)
	LOC100703727	Prostaglandin E receptor 4 (subtype EP4) b. (449 aa)
	stoml2	Stomatin (EPB72)-like 2. (356 aa)
	LOC100708854	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (812 aa)
	I3KKH7_ORENI	Uncharacterized protein. (653 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	LOC100706746	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (358 aa)
	Tbx21	T-box transcription factor 21. (605 aa)
	I3KWW1_ORENI	Cadherin 27. (922 aa)
	ENSONIP00000032417	Uncharacterized protein LOC100702023 isoform X1. (699 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (123 aa)
	nkx2-3	NK2 homeobox 3. (344 aa)
	LOC100694718	E3 ubiquitin-protein ligase. (877 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (570 aa)
	LOC100705061	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (449 aa)
	ENSONIP00000069694	annotation not available (265 aa)
	LOC100691479	Homeobox domain-containing protein. (360 aa)
	ENSONIP00000076946	Cadherin 26. (458 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000032417	LOC102077017	ENSONIP00000032417	ENSONIP00000002523	Uncharacterized protein LOC100702023 isoform X1.	Uncharacterized protein.	0.900
LOC100694718	LOC100697163	ENSONIP00000056551	ENSONIP00000011573	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC100694718	ripk2	ENSONIP00000056551	ENSONIP00000057830	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.587
LOC100697163	LOC100694718	ENSONIP00000011573	ENSONIP00000056551	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC100697163	ripk2	ENSONIP00000011573	ENSONIP00000057830	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.587
LOC100709775	rc3h1	ENSONIP00000004972	ENSONIP00000012524	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.672
LOC102077017	ENSONIP00000032417	ENSONIP00000002523	ENSONIP00000032417	Uncharacterized protein.	Uncharacterized protein LOC100702023 isoform X1.	0.900
Tbx21	batf	ENSONIP00000022950	ENSONIP00000048011	T-box transcription factor 21.	Basic leucine zipper transcription factor, ATF-like.	0.404
Tbx21	hlx	ENSONIP00000022950	ENSONIP00000007530	T-box transcription factor 21.	H2.0-like homeo box 1 (Drosophila).	0.585
batf	Tbx21	ENSONIP00000048011	ENSONIP00000022950	Basic leucine zipper transcription factor, ATF-like.	T-box transcription factor 21.	0.404
card11	ripk2	ENSONIP00000010724	ENSONIP00000057830	Caspase recruitment domain family, member 11.	Receptor-interacting serine-threonine kinase 2.	0.581
hlx	Tbx21	ENSONIP00000007530	ENSONIP00000022950	H2.0-like homeo box 1 (Drosophila).	T-box transcription factor 21.	0.585
rc3h1	LOC100709775	ENSONIP00000012524	ENSONIP00000004972	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.672
ripk2	LOC100694718	ENSONIP00000057830	ENSONIP00000056551	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.587
ripk2	LOC100697163	ENSONIP00000057830	ENSONIP00000011573	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.587
ripk2	card11	ENSONIP00000057830	ENSONIP00000010724	Receptor-interacting serine-threonine kinase 2.	Caspase recruitment domain family, member 11.	0.581