(44 nodes) Ribosome assembly network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mrps11	Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family. (212 aa)
	I3J1P0_ORENI	Coiled-coil domain containing 105. (406 aa)
	mrps7	Mitochondrial ribosomal protein S7. (223 aa)
	ngrn	Neugrin, neurite outgrowth associated. (307 aa)
	mterf3	Mitochondrial transcription termination factor 3. (428 aa)
	rpl23a	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family. (220 aa)
	traf7	TNF receptor-associated factor 7. (692 aa)
	LOC100706520	PWP2 small subunit processome component. (921 aa)
	dhx29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1376 aa)
	Brix1	Brix domain containing 2. (358 aa)
	rrp7a	Ribosomal RNA processing 7 homolog A. (282 aa)
	dhx30	DEAH (Asp-Glu-Ala-His) box helicase 30. (1156 aa)
	mpv17l2	MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (218 aa)
	Nop2	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (587 aa)
	mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
	rpl6	Ribosomal protein L6. (325 aa)
	mrpl22	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family. (208 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (465 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (288 aa)
	eif6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (246 aa)
	mrpl20	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family. (149 aa)
	ddx28	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28. (561 aa)
	ENSONIP00000029827	annotation not available (173 aa)
	RPL5	Ribosomal protein L5. (299 aa)
	RPL5-2	Large subunit ribosomal protein L5e. (316 aa)
	LOC100707344	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (312 aa)
	fastkd2	FAST kinase domains 2. (667 aa)
	rpl10	Ribosomal protein L10. (285 aa)
	LOC100691333	40S ribosomal protein S27. (93 aa)
	rps5	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (224 aa)
	dhx37	DEAH (Asp-Glu-Ala-His) box polypeptide 37. (1150 aa)
	rpf2	Ribosome production factor 2 homolog. (331 aa)
	sbds	SBDS ribosome maturation factor. (253 aa)
	LOC100705775	40S ribosomal protein S27 isoform X2. (92 aa)
	nip7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (202 aa)
	EFL1	Elongation factor like GTPase 1. (1098 aa)
	abt1	Activator of basal transcription 1. (323 aa)
	mrm2	Mitochondrial rRNA methyltransferase 2. (239 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (746 aa)
	eral1	Era-like 12S mitochondrial rRNA chaperone 1. (528 aa)
	ENSONIP00000076314	Small subunit ribosomal protein S27e. (84 aa)
	LOC100691767	Mitochondrial transcription termination factor 4. (338 aa)
	ENSONIP00000078162	Putative ATP-dependent RNA helicase DHX30. (529 aa)
	nle1	Notchless homolog 1 (Drosophila). (486 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brix1	LOC100706520	ENSONIP00000009737	ENSONIP00000008999	Brix domain containing 2.	PWP2 small subunit processome component.	0.816
Brix1	Nop2	ENSONIP00000009737	ENSONIP00000016227	Brix domain containing 2.	NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.970
Brix1	abt1	ENSONIP00000009737	ENSONIP00000064151	Brix domain containing 2.	Activator of basal transcription 1.	0.720
Brix1	ddx28	ENSONIP00000009737	ENSONIP00000025902	Brix domain containing 2.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28.	0.798
Brix1	eif6	ENSONIP00000009737	ENSONIP00000023371	Brix domain containing 2.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	0.924
Brix1	mrm2	ENSONIP00000009737	ENSONIP00000070098	Brix domain containing 2.	Mitochondrial rRNA methyltransferase 2.	0.861
Brix1	mrpl22	ENSONIP00000009737	ENSONIP00000020703	Brix domain containing 2.	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.792
Brix1	mrto4	ENSONIP00000009737	ENSONIP00000018003	Brix domain containing 2.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.991
Brix1	nip7	ENSONIP00000009737	ENSONIP00000058957	Brix domain containing 2.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.996
Brix1	nle1	ENSONIP00000009737	ENSONIP00000081516	Brix domain containing 2.	Notchless homolog 1 (Drosophila).	0.714
Brix1	nop53	ENSONIP00000009737	ENSONIP00000020940	Brix domain containing 2.	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.	0.801
Brix1	rpf2	ENSONIP00000009737	ENSONIP00000053094	Brix domain containing 2.	Ribosome production factor 2 homolog.	0.993
Brix1	rpl23a	ENSONIP00000009737	ENSONIP00000006133	Brix domain containing 2.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.868
Brix1	rpl6	ENSONIP00000009737	ENSONIP00000018087	Brix domain containing 2.	Ribosomal protein L6.	0.848
Brix1	rrp7a	ENSONIP00000009737	ENSONIP00000010517	Brix domain containing 2.	Ribosomal RNA processing 7 homolog A.	0.781
Brix1	sbds	ENSONIP00000009737	ENSONIP00000055538	Brix domain containing 2.	SBDS ribosome maturation factor.	0.450
EFL1	ENSONIP00000029827	ENSONIP00000063931	ENSONIP00000029827	Elongation factor like GTPase 1.	annotation not available	0.847
EFL1	ENSONIP00000076314	ENSONIP00000063931	ENSONIP00000076314	Elongation factor like GTPase 1.	Small subunit ribosomal protein S27e.	0.582
EFL1	I3J1P0_ORENI	ENSONIP00000063931	ENSONIP00000002780	Elongation factor like GTPase 1.	Coiled-coil domain containing 105.	0.855
EFL1	LOC100691333	ENSONIP00000063931	ENSONIP00000040768	Elongation factor like GTPase 1.	40S ribosomal protein S27.	0.582