(22 nodes) Protein kinase B signaling network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BANK1	B cell scaffold protein with ankyrin repeats 1. (679 aa)
	LOC100534578	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	LOC100696550	Platelet endothelial aggregation receptor 1. (1031 aa)
	gas6	Uncharacterized protein. (662 aa)
	LOC100694653	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC100707066	Interleukin-1. (244 aa)
	LOC100705478	C-mer proto-oncogene tyrosine kinase a. (1198 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (699 aa)
	LOC100692555	NK3 homeobox 1. (208 aa)
	flcn	Folliculin. (560 aa)
	LOC100690570	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (267 aa)
	TMEM100	Transmembrane protein 100. (139 aa)
	I3KIB4_ORENI	CD40 molecule, TNF receptor superfamily member 5. (193 aa)
	I3KMU3_ORENI	Insulin-like growth factor 1. (230 aa)
	LOC100701917	Uncharacterized protein. (496 aa)
	LOC100709560	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (530 aa)
	ENSONIP00000058930	Androgen-dependent TFPI-regulating protein-like. (230 aa)
	ILK	Integrin linked kinase. (460 aa)
	LOC100691710	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (515 aa)
	AXL	AXL receptor tyrosine kinase. (940 aa)
	tsc2	Rap-GAP domain-containing protein. (1899 aa)
	LOC100694444	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	LOC100707066	ENSONIP00000072861	ENSONIP00000010489	AXL receptor tyrosine kinase.	Interleukin-1.	0.431
AXL	gas6	ENSONIP00000072861	ENSONIP00000003964	AXL receptor tyrosine kinase.	Uncharacterized protein.	0.733
I3KIB4_ORENI	LOC100534578	ENSONIP00000039757	ENSONIP00000002809	CD40 molecule, TNF receptor superfamily member 5.	Tumor necrosis factor b (TNF superfamily, member 2).	0.701
I3KIB4_ORENI	LOC100690570	ENSONIP00000039757	ENSONIP00000020612	CD40 molecule, TNF receptor superfamily member 5.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.790
I3KIB4_ORENI	LOC100707066	ENSONIP00000039757	ENSONIP00000010489	CD40 molecule, TNF receptor superfamily member 5.	Interleukin-1.	0.528
I3KMU3_ORENI	LOC100534578	ENSONIP00000042664	ENSONIP00000002809	Insulin-like growth factor 1.	Tumor necrosis factor b (TNF superfamily, member 2).	0.570
I3KMU3_ORENI	LOC100690570	ENSONIP00000042664	ENSONIP00000020612	Insulin-like growth factor 1.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.465
I3KMU3_ORENI	LOC100694653	ENSONIP00000042664	ENSONIP00000007415	Insulin-like growth factor 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.679
I3KMU3_ORENI	LOC100707066	ENSONIP00000042664	ENSONIP00000010489	Insulin-like growth factor 1.	Interleukin-1.	0.545
ILK	LOC100701917	ENSONIP00000067253	ENSONIP00000047170	Integrin linked kinase.	Uncharacterized protein.	0.901
LOC100534578	I3KIB4_ORENI	ENSONIP00000002809	ENSONIP00000039757	Tumor necrosis factor b (TNF superfamily, member 2).	CD40 molecule, TNF receptor superfamily member 5.	0.701
LOC100534578	I3KMU3_ORENI	ENSONIP00000002809	ENSONIP00000042664	Tumor necrosis factor b (TNF superfamily, member 2).	Insulin-like growth factor 1.	0.570
LOC100534578	LOC100690570	ENSONIP00000002809	ENSONIP00000020612	Tumor necrosis factor b (TNF superfamily, member 2).	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.621
LOC100534578	LOC100694653	ENSONIP00000002809	ENSONIP00000007415	Tumor necrosis factor b (TNF superfamily, member 2).	Transforming growth factor beta; Belongs to the TGF-beta family.	0.746
LOC100534578	LOC100707066	ENSONIP00000002809	ENSONIP00000010489	Tumor necrosis factor b (TNF superfamily, member 2).	Interleukin-1.	0.953
LOC100534578	smpd3	ENSONIP00000002809	ENSONIP00000013663	Tumor necrosis factor b (TNF superfamily, member 2).	Sphingomyelin phosphodiesterase 3, neutral.	0.528
LOC100690570	I3KIB4_ORENI	ENSONIP00000020612	ENSONIP00000039757	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	CD40 molecule, TNF receptor superfamily member 5.	0.790
LOC100690570	I3KMU3_ORENI	ENSONIP00000020612	ENSONIP00000042664	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Insulin-like growth factor 1.	0.465
LOC100690570	LOC100534578	ENSONIP00000020612	ENSONIP00000002809	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Tumor necrosis factor b (TNF superfamily, member 2).	0.621
LOC100690570	LOC100707066	ENSONIP00000020612	ENSONIP00000010489	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Interleukin-1.	0.570