(15 nodes) Protein neddylation network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100707169	Ubiquitin-like modifier activating enzyme 3. (455 aa)
	LOC100692472	DCN1-like protein. (301 aa)
	dcun1d4	DCN1-like protein. (280 aa)
	Dcun1d2	DCN1-like protein. (272 aa)
	rnf7	Ring finger protein 7. (114 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
	ube2m	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
	dcun1d3	DCN1-like protein. (326 aa)
	nae1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (553 aa)
	LOC100690293	Ubiquitin-NEDD8-like protein RUB2. (183 aa)
	LOC100711516	Ubiquitin-like protein Nedd8. (95 aa)
	ube2f	Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family. (340 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (462 aa)
	LOC100705550	DCN1-like protein. (257 aa)
	LOC100703477	DCN1-like protein. (290 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dcun1d2	LOC100690293	ENSONIP00000004004	ENSONIP00000036290	DCN1-like protein.	Ubiquitin-NEDD8-like protein RUB2.	0.797
Dcun1d2	LOC100703477	ENSONIP00000004004	ENSONIP00000073193	DCN1-like protein.	DCN1-like protein.	0.480
Dcun1d2	LOC100707169	ENSONIP00000004004	ENSONIP00000079838	DCN1-like protein.	Ubiquitin-like modifier activating enzyme 3.	0.634
Dcun1d2	LOC100711516	ENSONIP00000004004	ENSONIP00000041372	DCN1-like protein.	Ubiquitin-like protein Nedd8.	0.797
Dcun1d2	UBA3	ENSONIP00000004004	ENSONIP00000063914	DCN1-like protein.	Ubiquitin like modifier activating enzyme 3.	0.634
Dcun1d2	dcun1d3	ENSONIP00000004004	ENSONIP00000025104	DCN1-like protein.	DCN1-like protein.	0.525
Dcun1d2	dcun1d4	ENSONIP00000004004	ENSONIP00000003815	DCN1-like protein.	DCN1-like protein.	0.471
Dcun1d2	nae1	ENSONIP00000004004	ENSONIP00000033388	DCN1-like protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.667
Dcun1d2	rbx1	ENSONIP00000004004	ENSONIP00000010640	DCN1-like protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.894
Dcun1d2	rnf7	ENSONIP00000004004	ENSONIP00000007154	DCN1-like protein.	Ring finger protein 7.	0.749
Dcun1d2	ube2f	ENSONIP00000004004	ENSONIP00000042549	DCN1-like protein.	Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.818
Dcun1d2	ube2m	ENSONIP00000004004	ENSONIP00000011667	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.818
LOC100690293	Dcun1d2	ENSONIP00000036290	ENSONIP00000004004	Ubiquitin-NEDD8-like protein RUB2.	DCN1-like protein.	0.797
LOC100690293	LOC100692472	ENSONIP00000036290	ENSONIP00000074133	Ubiquitin-NEDD8-like protein RUB2.	DCN1-like protein.	0.797
LOC100690293	LOC100703477	ENSONIP00000036290	ENSONIP00000073193	Ubiquitin-NEDD8-like protein RUB2.	DCN1-like protein.	0.705
LOC100690293	LOC100705550	ENSONIP00000036290	ENSONIP00000065861	Ubiquitin-NEDD8-like protein RUB2.	DCN1-like protein.	0.797
LOC100690293	LOC100707169	ENSONIP00000036290	ENSONIP00000079838	Ubiquitin-NEDD8-like protein RUB2.	Ubiquitin-like modifier activating enzyme 3.	0.924
LOC100690293	UBA3	ENSONIP00000036290	ENSONIP00000063914	Ubiquitin-NEDD8-like protein RUB2.	Ubiquitin like modifier activating enzyme 3.	0.924
LOC100690293	dcun1d3	ENSONIP00000036290	ENSONIP00000025104	Ubiquitin-NEDD8-like protein RUB2.	DCN1-like protein.	0.811
LOC100690293	dcun1d4	ENSONIP00000036290	ENSONIP00000003815	Ubiquitin-NEDD8-like protein RUB2.	DCN1-like protein.	0.705