(54 nodes) Fat cell differentiation network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100707205	G_PROTEIN_RECEP_F1_2 domain-containing protein. (342 aa)
	ctbp1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (469 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (519 aa)
	bbs9	Bardet-Biedl syndrome 9. (995 aa)
	ttc8	Tetratricopeptide repeat domain 8. (513 aa)
	Nr4a3	Nuclear receptor subfamily 4, group A, member 3. (597 aa)
	bbs4	Bardet-Biedl syndrome 4. (539 aa)
	LOC100704845	Uncharacterized protein. (1200 aa)
	LOC100698659	Uncharacterized protein. (1034 aa)
	retreg1	Reticulophagy regulator 1. (352 aa)
	LOC100711139	Transmembrane protein 120A. (398 aa)
	Prdm16	LOW QUALITY PROTEIN: PR domain zinc finger protein 16. (184 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (627 aa)
	ENSONIP00000039307	annotation not available (846 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1834 aa)
	LOC100703084	Zgc:103681. (364 aa)
	I3K8K9_ORENI	Transmembrane protein 120B. (347 aa)
	LOC100701144	Leucine-rich alpha-2-glycoprotein. (332 aa)
	cebpd	CCAAT/enhancer-binding protein. (271 aa)
	Trim32	Tripartite motif containing 32. (681 aa)
	LOC106096946	LRRCT domain-containing protein. (334 aa)
	bbs12	Bardet-Biedl syndrome 12. (658 aa)
	adrb1	Adrenoceptor beta 1. (397 aa)
	socs1	Uncharacterized protein. (215 aa)
	LOC100706475	Adrenoceptor beta 2, surface a; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	dhrs7b	Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (592 aa)
	bbs1	Bardet-Biedl syndrome 1. (583 aa)
	FFAR4	Free fatty acid receptor 4. (352 aa)
	LOC100709939	Nuclear receptor subfamily 4, group A, member 1. (575 aa)
	plac8	Placenta associated 8, tandem duplicate 1. (150 aa)
	LOC100695966	Activating transcription factor 5b. (471 aa)
	LOC100694602	Uncharacterized protein. (581 aa)
	LOC100694011	Metalloreductase STEAP4. (467 aa)
	LOC100699837	BSCL2 lipid droplet biogenesis associated, seipin. (421 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (712 aa)
	mkks	McKusick-Kaufman syndrome. (582 aa)
	ZNF516	Zinc finger protein 516. (1104 aa)
	LOC100693968	Activating transcription factor 5a. (505 aa)
	I3JCX6_ORENI	BSCL2 lipid droplet biogenesis associated, seipin, like. (236 aa)
	Cntn2	Contactin 2. (1052 aa)
	I3JAF0_ORENI	Uncharacterized protein. (741 aa)
	Hmga2	Uncharacterized protein. (132 aa)
	ENSONIP00000002644	Si:ch211-263k4.2. (779 aa)
	bbs7	Bardet-Biedl syndrome 7. (715 aa)
	LOC100706096	Aldedh domain-containing protein. (525 aa)
	LOC100698988	E1A binding protein p300 a. (2777 aa)
	nr4a2	Nuclear receptor subfamily 4, group A, member 2b. (600 aa)
	ENSONIP00000067169	Prolactin-releasing peptide-like. (66 aa)
	ENSONIP00000065796	Metalloreductase STEAP4. (467 aa)
	LOC100700725	E1A binding protein p300 b. (2799 aa)
	fam120b	Constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X1. (742 aa)
	LOC100707048	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (494 aa)
	steap4	STEAP family member 4. (479 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH6A1	LOC100706096	ENSONIP00000072252	ENSONIP00000001119	Aldehyde dehydrogenase 6 family member A1.	Aldedh domain-containing protein.	0.900
ALDH6A1	ttc8	ENSONIP00000072252	ENSONIP00000060386	Aldehyde dehydrogenase 6 family member A1.	Tetratricopeptide repeat domain 8.	0.472
ENSONIP00000002644	ENSONIP00000039307	ENSONIP00000002644	ENSONIP00000039307	Si:ch211-263k4.2.	annotation not available	0.509
ENSONIP00000002644	Prdm16	ENSONIP00000002644	ENSONIP00000044154	Si:ch211-263k4.2.	LOW QUALITY PROTEIN: PR domain zinc finger protein 16.	0.872
ENSONIP00000002644	ZNF516	ENSONIP00000002644	ENSONIP00000009202	Si:ch211-263k4.2.	Zinc finger protein 516.	0.509
ENSONIP00000039307	ENSONIP00000002644	ENSONIP00000039307	ENSONIP00000002644	annotation not available	Si:ch211-263k4.2.	0.509
ENSONIP00000039307	LOC100698659	ENSONIP00000039307	ENSONIP00000050726	annotation not available	Uncharacterized protein.	0.450
ENSONIP00000039307	LOC100704845	ENSONIP00000039307	ENSONIP00000051960	annotation not available	Uncharacterized protein.	0.450
ENSONIP00000039307	LOC100707048	ENSONIP00000039307	ENSONIP00000064840	annotation not available	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.450
ENSONIP00000039307	Prdm16	ENSONIP00000039307	ENSONIP00000044154	annotation not available	LOW QUALITY PROTEIN: PR domain zinc finger protein 16.	0.509
ENSONIP00000039307	ctbp1	ENSONIP00000039307	ENSONIP00000070456	annotation not available	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.450
FFAR4	LOC100707205	ENSONIP00000023256	ENSONIP00000068379	Free fatty acid receptor 4.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.574
LOC100693968	cebpd	ENSONIP00000006796	ENSONIP00000026731	Activating transcription factor 5a.	CCAAT/enhancer-binding protein.	0.427
LOC100694602	med1	ENSONIP00000015276	ENSONIP00000038435	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.475
LOC100695966	cebpd	ENSONIP00000018596	ENSONIP00000026731	Activating transcription factor 5b.	CCAAT/enhancer-binding protein.	0.427
LOC100698659	ENSONIP00000039307	ENSONIP00000050726	ENSONIP00000039307	Uncharacterized protein.	annotation not available	0.450
LOC100698659	LOC100698988	ENSONIP00000050726	ENSONIP00000072968	Uncharacterized protein.	E1A binding protein p300 a.	0.400
LOC100698659	LOC100700725	ENSONIP00000050726	ENSONIP00000075311	Uncharacterized protein.	E1A binding protein p300 b.	0.400
LOC100698659	ZNF516	ENSONIP00000050726	ENSONIP00000009202	Uncharacterized protein.	Zinc finger protein 516.	0.450
LOC100698659	med1	ENSONIP00000050726	ENSONIP00000038435	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.491