(31 nodes) Response to ethanol network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I3K513_ORENI	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (448 aa)
	nr0b2	Orphan nuclear receptor SHP. (258 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (296 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (481 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (333 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1245 aa)
	LOC100703394	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	LOC102080527	Si:dkey-30c15.17. (645 aa)
	LOC100701737	Uncharacterized protein. (342 aa)
	I3K441_ORENI	Uncharacterized protein. (268 aa)
	LOC100704176	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	LOC100696323	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1475 aa)
	Ogg1	8-oxoguanine DNA glycosylase. (416 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC100706164	Zgc:153993. (203 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2581 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	LOC100707064	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (485 aa)
	tufm	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (451 aa)
	ENSONIP00000039296	annotation not available (530 aa)
	LOC100698328	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (195 aa)
	FGFR1	Fibroblast growth factor receptor. (862 aa)
	LOC100706558	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (640 aa)
	LOC100711741	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (488 aa)
	LOC100690411	Glycine receptor subunit alpha-3 isoform X1. (511 aa)
	tbxa2r	Thromboxane A2 receptor. (368 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
	cd164	Sialomucin core protein 24 isoform X1. (176 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGFR1	fgf19	ENSONIP00000054183	ENSONIP00000022796	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.688
I3K441_ORENI	fgf19	ENSONIP00000015886	ENSONIP00000022796	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.688
LOC100701737	fgf19	ENSONIP00000015199	ENSONIP00000022796	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.499
LOC100701737	nr0b2	ENSONIP00000015199	ENSONIP00000067688	Uncharacterized protein.	Orphan nuclear receptor SHP.	0.590
LOC100703394	LOC100707064	ENSONIP00000013380	ENSONIP00000026611	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.756
LOC100703394	cldn5	ENSONIP00000013380	ENSONIP00000025737	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.758
LOC100707064	LOC100703394	ENSONIP00000026611	ENSONIP00000013380	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.756
LOC100707064	cldn5	ENSONIP00000026611	ENSONIP00000025737	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.655
LOC102080527	ache	ENSONIP00000015160	ENSONIP00000059360	Si:dkey-30c15.17.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.913
ache	LOC102080527	ENSONIP00000059360	ENSONIP00000015160	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Si:dkey-30c15.17.	0.913
cldn5	LOC100703394	ENSONIP00000025737	ENSONIP00000013380	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.758
cldn5	LOC100707064	ENSONIP00000025737	ENSONIP00000026611	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.655
fgf19	FGFR1	ENSONIP00000022796	ENSONIP00000054183	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.688
fgf19	I3K441_ORENI	ENSONIP00000022796	ENSONIP00000015886	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.688
fgf19	LOC100701737	ENSONIP00000022796	ENSONIP00000015199	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.499
fgf19	nr0b2	ENSONIP00000022796	ENSONIP00000067688	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Orphan nuclear receptor SHP.	0.590
nr0b2	LOC100701737	ENSONIP00000067688	ENSONIP00000015199	Orphan nuclear receptor SHP.	Uncharacterized protein.	0.590
nr0b2	fgf19	ENSONIP00000067688	ENSONIP00000022796	Orphan nuclear receptor SHP.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.590